STRINGSTRING
MYL12A MYL12A MEIS1 MEIS1 PAX2 PAX2 CTNNB1 CTNNB1 LEF1 LEF1 LHX1 LHX1 PDGFRA PDGFRA ROCK1 ROCK1 SIX2 SIX2 TGFB1 TGFB1 ROCK2 ROCK2 ACTB ACTB NPHS1 NPHS1 WNT11 WNT11 RET RET FAT4 FAT4 JAG1 JAG1 FGF9 FGF9 SLC12A1 SLC12A1 MYH9 MYH9 MYH10 MYH10 ITGA8 ITGA8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL12AMyosin light chain 12A. (178 aa)
MEIS1Meis homeobox 1. (465 aa)
PAX2Paired box 2. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
LEF1HMG box domain-containing protein. (430 aa)
LHX1LIM homeobox 1. (406 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SIX2SIX homeobox 2. (296 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ACTBUncharacterized protein. (375 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1233 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SLC12A1Solute carrier family 12 member 1. (1094 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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