(10 nodes) (2023) The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SP3	Sp3 transcription factor. (778 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ALB	Serum albumin. (608 aa)
	ELN	Uncharacterized protein. (504 aa)
	LOC102176111	Triosephosphate isomerase. (201 aa)
	TPI1	Triosephosphate isomerase. (295 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
	PGK1	Phosphoglycerate kinase. (424 aa)
	ENSCHIP00000004162	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (515 aa)
	PGK2	Phosphoglycerate kinase. (417 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	ELN	ENSCHIP00000020234	ENSCHIP00000018772	Serum albumin.	Uncharacterized protein.	0.725
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	PGK1	ENSCHIP00000020234	ENSCHIP00000005700	Serum albumin.	Phosphoglycerate kinase.	0.604
ALB	PGK2	ENSCHIP00000020234	ENSCHIP00000001811	Serum albumin.	Phosphoglycerate kinase.	0.495
ALB	PLG	ENSCHIP00000020234	ENSCHIP00000007843	Serum albumin.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.976
ALB	SP3	ENSCHIP00000020234	ENSCHIP00000029194	Serum albumin.	Sp3 transcription factor.	0.414
ALB	TPI1	ENSCHIP00000020234	ENSCHIP00000015387	Serum albumin.	Triosephosphate isomerase.	0.435
ELN	ALB	ENSCHIP00000018772	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.725
ELN	GAPDH	ENSCHIP00000018772	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.726
ELN	PLG	ENSCHIP00000018772	ENSCHIP00000007843	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.421
GAPDH	ALB	ENSCHIP00000025974	ENSCHIP00000020234	Glyceraldehyde-3-phosphate dehydrogenase.	Serum albumin.	0.948
GAPDH	ELN	ENSCHIP00000025974	ENSCHIP00000018772	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.726
GAPDH	LOC102176111	ENSCHIP00000025974	ENSCHIP00000015953	Glyceraldehyde-3-phosphate dehydrogenase.	Triosephosphate isomerase.	0.928
GAPDH	PGK1	ENSCHIP00000025974	ENSCHIP00000005700	Glyceraldehyde-3-phosphate dehydrogenase.	Phosphoglycerate kinase.	0.996
GAPDH	PGK2	ENSCHIP00000025974	ENSCHIP00000001811	Glyceraldehyde-3-phosphate dehydrogenase.	Phosphoglycerate kinase.	0.993
GAPDH	PLG	ENSCHIP00000025974	ENSCHIP00000007843	Glyceraldehyde-3-phosphate dehydrogenase.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.845
GAPDH	SP3	ENSCHIP00000025974	ENSCHIP00000029194	Glyceraldehyde-3-phosphate dehydrogenase.	Sp3 transcription factor.	0.483
GAPDH	TPI1	ENSCHIP00000025974	ENSCHIP00000015387	Glyceraldehyde-3-phosphate dehydrogenase.	Triosephosphate isomerase.	0.994
LOC102176111	GAPDH	ENSCHIP00000015953	ENSCHIP00000025974	Triosephosphate isomerase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.928
LOC102176111	PGK1	ENSCHIP00000015953	ENSCHIP00000005700	Triosephosphate isomerase.	Phosphoglycerate kinase.	0.962