(51 nodes) (2024) Integrative Analyses of Pyrimidine Salvage Pathway-Related Genes Revealing the Associations Between UPP1 and Tumor Microenvironment. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	LOC102189615	Galectin. (186 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (221 aa)
	ALK	Tyrosine-protein kinase receptor. (1309 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (307 aa)
	LOC102184087	Galectin. (342 aa)
	CD4	CD4 molecule. (455 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
	FGFR1	Fibroblast growth factor receptor. (860 aa)
	LAMA2	Laminin subunit alpha 2. (3116 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
	NFASC	Neurofascin. (1180 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	VWF	Von Willebrand factor. (2819 aa)
	SINHCAF	Uncharacterized protein. (221 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (312 aa)
	UCKL1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (552 aa)
	CCL14	C-C motif chemokine ligand 14. (94 aa)
	CD86	Ig-like domain-containing protein. (289 aa)
	CCL5	C-C motif chemokine. (91 aa)
	IL10	Interleukin 10. (177 aa)
	LOC106503912	Galectin. (116 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (330 aa)
	ACTA2	Actin alpha 2, smooth muscle. (377 aa)
	LOC102177285	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (771 aa)
	LOC102187672	Galectin. (185 aa)
	IGFBP6	Uncharacterized protein. (237 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (270 aa)
	CD276	CD276 molecule. (533 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	IL7R	Interleukin 7 receptor. (459 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1067 aa)
	CD47	CD47 molecule. (321 aa)
	PRPSAP2	Phosphoribosyl pyrophosphate synthetase associated protein 2. (413 aa)
	EPCAM	Epithelial cell adhesion molecule. (314 aa)
	CCL26	C-C motif chemokine. (94 aa)
	CCL2	C-C motif chemokine. (98 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	LOC102182683	C-X-C motif chemokine. (109 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	LOC102180880	C-C motif chemokine. (92 aa)
	CD70	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (258 aa)
	AFF3	AF4/FMR2 family member 3. (1228 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	CTNNB1	ENSCHIP00000018506	ENSCHIP00000031016	Actin alpha 2, smooth muscle.	Catenin beta 1.	0.407
ACTA2	EPCAM	ENSCHIP00000018506	ENSCHIP00000026828	Actin alpha 2, smooth muscle.	Epithelial cell adhesion molecule.	0.477
ACTA2	MYH11	ENSCHIP00000018506	ENSCHIP00000007181	Actin alpha 2, smooth muscle.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.993
ACTA2	TGFB1	ENSCHIP00000018506	ENSCHIP00000008885	Actin alpha 2, smooth muscle.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.546
ACTA2	VWF	ENSCHIP00000018506	ENSCHIP00000010569	Actin alpha 2, smooth muscle.	Von Willebrand factor.	0.513
ALK	CD4	ENSCHIP00000004260	ENSCHIP00000006662	Tyrosine-protein kinase receptor.	CD4 molecule.	0.421
ALK	CTNNB1	ENSCHIP00000004260	ENSCHIP00000031016	Tyrosine-protein kinase receptor.	Catenin beta 1.	0.576
ALK	EGFR	ENSCHIP00000004260	ENSCHIP00000022759	Tyrosine-protein kinase receptor.	Receptor protein-tyrosine kinase.	0.614
ALK	TGFB1	ENSCHIP00000004260	ENSCHIP00000008885	Tyrosine-protein kinase receptor.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.593
CCL14	CCL21	ENSCHIP00000013984	ENSCHIP00000031286	C-C motif chemokine ligand 14.	C-C motif chemokine ligand 21.	0.848
CCL14	CCL26	ENSCHIP00000013984	ENSCHIP00000027644	C-C motif chemokine ligand 14.	C-C motif chemokine.	0.747
CCL14	CCL5	ENSCHIP00000013984	ENSCHIP00000016425	C-C motif chemokine ligand 14.	C-C motif chemokine.	0.812
CCL14	CXCL12	ENSCHIP00000013984	ENSCHIP00000007530	C-C motif chemokine ligand 14.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.843
CCL14	IL10	ENSCHIP00000013984	ENSCHIP00000016929	C-C motif chemokine ligand 14.	Interleukin 10.	0.486
CCL14	IL1B	ENSCHIP00000013984	ENSCHIP00000029274	C-C motif chemokine ligand 14.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.409
CCL14	LOC102182683	ENSCHIP00000013984	ENSCHIP00000028640	C-C motif chemokine ligand 14.	C-X-C motif chemokine.	0.507
CCL2	CCL21	ENSCHIP00000027804	ENSCHIP00000031286	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.714
CCL2	CCL26	ENSCHIP00000027804	ENSCHIP00000027644	C-C motif chemokine.	C-C motif chemokine.	0.981
CCL2	CCL5	ENSCHIP00000027804	ENSCHIP00000016425	C-C motif chemokine.	C-C motif chemokine.	0.983
CCL2	CD4	ENSCHIP00000027804	ENSCHIP00000006662	C-C motif chemokine.	CD4 molecule.	0.948