(14 nodes) (2024) Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	TBX5	T-box transcription factor 5. (594 aa)
	BECN1	Uncharacterized protein. (448 aa)
	TNNT2	Troponin T2, cardiac type. (267 aa)
	ALB	Serum albumin. (608 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
	BMI1	RING-type domain-containing protein. (437 aa)
	MEF2C	MADS-box domain-containing protein. (441 aa)
	ACTB	Uncharacterized protein. (375 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
	ACTN2	Actinin alpha 2. (902 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN2	ENSCHIP00000011080	ENSCHIP00000006208	Uncharacterized protein.	Actinin alpha 2.	0.501
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BECN1	ENSCHIP00000011080	ENSCHIP00000024304	Uncharacterized protein.	Uncharacterized protein.	0.886
ACTB	BMI1	ENSCHIP00000011080	ENSCHIP00000016491	Uncharacterized protein.	RING-type domain-containing protein.	0.697
ACTB	HDAC4	ENSCHIP00000011080	ENSCHIP00000019494	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.626
ACTB	HDAC7	ENSCHIP00000011080	ENSCHIP00000009920	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.419
ACTB	MEF2C	ENSCHIP00000011080	ENSCHIP00000015775	Uncharacterized protein.	MADS-box domain-containing protein.	0.473
ACTB	TNNT2	ENSCHIP00000011080	ENSCHIP00000022908	Uncharacterized protein.	Troponin T2, cardiac type.	0.467
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTC1	ACTN2	ENSCHIP00000002085	ENSCHIP00000006208	Actin alpha cardiac muscle 1.	Actinin alpha 2.	0.861
ACTC1	MEF2C	ENSCHIP00000002085	ENSCHIP00000015775	Actin alpha cardiac muscle 1.	MADS-box domain-containing protein.	0.681
ACTC1	TBX5	ENSCHIP00000002085	ENSCHIP00000028388	Actin alpha cardiac muscle 1.	T-box transcription factor 5.	0.674
ACTC1	TNNT2	ENSCHIP00000002085	ENSCHIP00000022908	Actin alpha cardiac muscle 1.	Troponin T2, cardiac type.	0.817
ACTN2	ACTB	ENSCHIP00000006208	ENSCHIP00000011080	Actinin alpha 2.	Uncharacterized protein.	0.501
ACTN2	ACTC1	ENSCHIP00000006208	ENSCHIP00000002085	Actinin alpha 2.	Actin alpha cardiac muscle 1.	0.861
ACTN2	MEF2C	ENSCHIP00000006208	ENSCHIP00000015775	Actinin alpha 2.	MADS-box domain-containing protein.	0.580
ACTN2	TBX5	ENSCHIP00000006208	ENSCHIP00000028388	Actinin alpha 2.	T-box transcription factor 5.	0.671
ACTN2	TNNT2	ENSCHIP00000006208	ENSCHIP00000022908	Actinin alpha 2.	Troponin T2, cardiac type.	0.902
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	BECN1	ENSCHIP00000020234	ENSCHIP00000024304	Serum albumin.	Uncharacterized protein.	0.764