22 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	AR	Androgen receptor. (891 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	MMUT	Methylmalonyl-CoA mutase. (771 aa)
	FOXA1	Forkhead box A1. (468 aa)
	CEL	Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. (768 aa)
	ZNF234	Zinc finger protein 234. (678 aa)
	HOXB13	Homeobox B13. (285 aa)
	NPY	Neuropeptide Y. (97 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	LOC102176799	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4878 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (385 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	CDH3	Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (831 aa)
	TWIST1	BHLH domain-containing protein. (163 aa)
	LOC102181016	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
	CHGA	Chromogranin A. (534 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PXDN	Peroxidasin. (1525 aa)
	ENO2	Uncharacterized protein. (441 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	EZH2	ENSCHIP00000006557	ENSCHIP00000003420	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.525
AGO2	GAPDH	ENSCHIP00000006557	ENSCHIP00000025974	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.824
AGO2	GAPDHS	ENSCHIP00000006557	ENSCHIP00000005676	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.587
AGO2	LOC102176799	ENSCHIP00000006557	ENSCHIP00000004827	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.634
AGO2	LOC102181016	ENSCHIP00000006557	ENSCHIP00000010405	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.584
AGO2	MMUT	ENSCHIP00000006557	ENSCHIP00000027222	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Methylmalonyl-CoA mutase.	0.905
AGO2	PXDN	ENSCHIP00000006557	ENSCHIP00000015493	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Peroxidasin.	0.637
AGO2	STAT3	ENSCHIP00000006557	ENSCHIP00000022282	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Signal transducer and activator of transcription.	0.442
AR	CHGA	ENSCHIP00000024342	ENSCHIP00000014620	Androgen receptor.	Chromogranin A.	0.597
AR	EZH2	ENSCHIP00000024342	ENSCHIP00000003420	Androgen receptor.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.786
AR	FOXA1	ENSCHIP00000024342	ENSCHIP00000027706	Androgen receptor.	Forkhead box A1.	0.935
AR	GAPDH	ENSCHIP00000024342	ENSCHIP00000025974	Androgen receptor.	Glyceraldehyde-3-phosphate dehydrogenase.	0.792
AR	GAPDHS	ENSCHIP00000024342	ENSCHIP00000005676	Androgen receptor.	Glyceraldehyde-3-phosphate dehydrogenase.	0.474
AR	HOXB13	ENSCHIP00000024342	ENSCHIP00000032940	Androgen receptor.	Homeobox B13.	0.662
AR	LOC102176799	ENSCHIP00000024342	ENSCHIP00000004827	Androgen receptor.	Glyceraldehyde-3-phosphate dehydrogenase.	0.506
AR	LOC102181016	ENSCHIP00000024342	ENSCHIP00000010405	Androgen receptor.	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.468
AR	PXDN	ENSCHIP00000024342	ENSCHIP00000015493	Androgen receptor.	Peroxidasin.	0.720
AR	STAT3	ENSCHIP00000024342	ENSCHIP00000022282	Androgen receptor.	Signal transducer and activator of transcription.	0.750
CEL	PXDN	ENSCHIP00000030222	ENSCHIP00000015493	Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family.	Peroxidasin.	0.550
CHGA	AR	ENSCHIP00000014620	ENSCHIP00000024342	Chromogranin A.	Androgen receptor.	0.597