STRINGSTRING
PXDN PXDN LOC102176799 LOC102176799 GAPDHS GAPDHS CD4 CD4 INS INS IL6 IL6 LOC102181016 LOC102181016 ACTB ACTB PRKDC PRKDC FOXP3 FOXP3 RAD51 RAD51 CTNNB1 CTNNB1 CHEK1 CHEK1 TP53 TP53 LOC102182683 LOC102182683 CDC25A CDC25A CALR CALR NRAS NRAS SQSTM1 SQSTM1 ARAF ARAF GAPDH GAPDH TLR6 TLR6 IL18 IL18 AXIN2 AXIN2 STAT3 STAT3 ALB ALB IGF1 IGF1 BRAF BRAF CGAS CGAS LGR5 LGR5 MYD88 MYD88 PRKCB PRKCB IFNG IFNG TNF TNF PCNA PCNA BEST4 BEST4 CDK1 CDK1 OCLN OCLN CDK2 CDK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PXDNPeroxidasin. (1525 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (385 aa)
CD4CD4 molecule. (455 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC102181016Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
ACTBUncharacterized protein. (375 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
FOXP3Forkhead box P3. (463 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CTNNB1Catenin beta 1. (781 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
CDC25ACell division cycle 25A. (517 aa)
CALRCalreticulin. (417 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SQSTM1Sequestosome 1. (440 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TLR6Toll-like receptor. (966 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
AXIN2Axin 2. (844 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ALBSerum albumin. (608 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
CGASCyclic GMP-AMP synthase. (511 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (467 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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