STRINGSTRING
PTGES3 PTGES3 PTGS1 PTGS1 SLC44A2 SLC44A2 LPCAT1 LPCAT1 ASAH1 ASAH1 CYP51A1 CYP51A1 CD4 CD4 ETNK1 ETNK1 TBL1XR1 TBL1XR1 PRKAR1A PRKAR1A HSD17B11 HSD17B11 IL6 IL6 ACER3 ACER3 PPP1CB PPP1CB MED23 MED23 PPP1CC PPP1CC PIK3CA PIK3CA CCNC CCNC GPCPD1 GPCPD1 FASN FASN SACM1L SACM1L IL4 IL4 LEP LEP STAT3 STAT3 SGPP1 SGPP1 TXNRD1 TXNRD1 SCD SCD ACSL3 ACSL3 GAPDH GAPDH ACSL1 ACSL1 MTMR6 MTMR6 IDI1 IDI1 IL1B IL1B ABHD3 ABHD3 TRADD TRADD PPT1 PPT1 CD36 CD36 DDHD1 DDHD1 SEC23A SEC23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGES3CS domain-containing protein. (155 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (600 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (706 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (533 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (400 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (504 aa)
CD4CD4 molecule. (455 aa)
ETNK1Ethanolamine kinase 1. (431 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (520 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
HSD17B11Hydroxysteroid 17-beta dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (223 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MED23Mediator complex subunit 23. (1374 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (314 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCNCUncharacterized protein; Belongs to the cyclin family. (283 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (587 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
TXNRD1Thioredoxin reductase 1. (587 aa)
SCDAcyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (359 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (719 aa)
MTMR6Myotubularin related protein 6. (621 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (287 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ABHD3Abhydrolase domain containing 3. (411 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (472 aa)
DDHD1DDHD domain containing 1. (876 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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