(47 nodes) Pyrimidine metabolism network (Capra hircus)

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	DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
	CTPS2	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa)
	DCTPP1	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (169 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (389 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
	CMPK1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
	LOC102176691	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	DUT	dUTPase domain-containing protein. (242 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	DCTD	Deoxycytidylate deaminase. (178 aa)
	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	NUDT2	Nudix hydrolase 2; Belongs to the Nudix hydrolase family. (147 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (458 aa)
	ENTPD6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (312 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1033 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (570 aa)
	UPRT	Uracil phosphoribosyltransferase homolog. (306 aa)
	TK1	Thymidine kinase. (238 aa)
	CANT1	Calcium activated nucleotidase 1. (401 aa)
	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (517 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (330 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (225 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
	NME3	Nucleoside diphosphate kinase. (169 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
	NME2	Nucleoside diphosphate kinase. (152 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2242 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
	NME4	Nucleoside diphosphate kinase. (187 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
	DTYMK	Deoxythymidylate kinase. (212 aa)
	NT5C	5', 3'-nucleotidase, cytosolic. (216 aa)
	TK2	Thymidine kinase 2. (275 aa)
	DCK	Deoxycytidine kinase. (260 aa)
	DPYS	Dihydropyrimidinase. (516 aa)
	AK9	Uncharacterized protein. (426 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
	ENTPD5	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (365 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK9	CANT1	ENSCHIP00000031711	ENSCHIP00000016954	Uncharacterized protein.	Calcium activated nucleotidase 1.	0.712
AK9	CMPK1	ENSCHIP00000031711	ENSCHIP00000005880	Uncharacterized protein.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.920
AK9	CMPK2	ENSCHIP00000031711	ENSCHIP00000010184	Uncharacterized protein.	Cytidine/uridine monophosphate kinase 2.	0.949
AK9	CTPS1	ENSCHIP00000031711	ENSCHIP00000032816	Uncharacterized protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.939
AK9	CTPS2	ENSCHIP00000031711	ENSCHIP00000001652	Uncharacterized protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.939
AK9	DCK	ENSCHIP00000031711	ENSCHIP00000030481	Uncharacterized protein.	Deoxycytidine kinase.	0.919
AK9	DCTPP1	ENSCHIP00000031711	ENSCHIP00000004507	Uncharacterized protein.	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	0.906
AK9	DTYMK	ENSCHIP00000031711	ENSCHIP00000029045	Uncharacterized protein.	Deoxythymidylate kinase.	0.949
AK9	DUT	ENSCHIP00000031711	ENSCHIP00000006896	Uncharacterized protein.	dUTPase domain-containing protein.	0.935
AK9	ENPP3	ENSCHIP00000031711	ENSCHIP00000000863	Uncharacterized protein.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.910
AK9	ENTPD1	ENSCHIP00000031711	ENSCHIP00000017745	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family.	0.910
AK9	ENTPD3	ENSCHIP00000031711	ENSCHIP00000028342	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.910
AK9	ENTPD4	ENSCHIP00000031711	ENSCHIP00000018009	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family.	0.688
AK9	ENTPD5	ENSCHIP00000031711	ENSCHIP00000033122	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family.	0.691
AK9	ENTPD6	ENSCHIP00000031711	ENSCHIP00000010935	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family.	0.691
AK9	ENTPD8	ENSCHIP00000031711	ENSCHIP00000008871	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family.	0.910
AK9	NME2	ENSCHIP00000031711	ENSCHIP00000024130	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.940
AK9	NME3	ENSCHIP00000031711	ENSCHIP00000023280	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.941
AK9	NME4	ENSCHIP00000031711	ENSCHIP00000027963	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.940
AK9	NME6	ENSCHIP00000031711	ENSCHIP00000032373	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.940