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PDHA1 PDHA1 GLUD1 GLUD1 PFKL PFKL HK1 HK1 ME2 ME2 SDHD SDHD ALDOB ALDOB SHMT2 SHMT2 FH FH PGK2 PGK2 IDH2 IDH2 PGAM2 PGAM2 TKTL1 TKTL1 PKLR PKLR PRPS2 PRPS2 OGDH OGDH PCCA PCCA ACO1 ACO1 GLYCTK GLYCTK ACO2 ACO2 PDHA2 PDHA2 PRPS1L1 PRPS1L1 PSPH PSPH SDHC SDHC ALDOC ALDOC PGK1 PGK1 LOC108634030 LOC108634030 EHHADH EHHADH HKDC1 HKDC1 TALDO1 TALDO1 IDH3B IDH3B RGN RGN ALDH6A1 ALDH6A1 PDHB PDHB SDSL SDSL HK2 HK2 ACADS ACADS LOC102181016 LOC102181016 GOT2 GOT2 SHMT1 SHMT1 ALDOA ALDOA PGP PGP H6PD H6PD IDH3A IDH3A ME3 ME3 TKTL2 TKTL2 G6PD G6PD ACOX3 ACOX3 GOT1L1 GOT1L1 HAO1 HAO1 GCK GCK MDH1 MDH1 ENO1 ENO1 TPI1 TPI1 PKM PKM GPI GPI RPIA RPIA IDH3G IDH3G GPT GPT ACAT2 ACAT2 FBP2 FBP2 AMT AMT RPE RPE LOC102173923 LOC102173923 SDHA SDHA IDH1 IDH1 ENO2 ENO2 PHGDH PHGDH SUCLA2 SUCLA2 ENO4 ENO4 ENO3 ENO3 SUCLG2 SUCLG2 MCEE MCEE SUCLG1 SUCLG1 DLAT DLAT PCCB PCCB CAT CAT ACAT1 ACAT1 ESD ESD ACSS1 ACSS1 TKT TKT SDS SDS GLDC GLDC PC PC AGXT AGXT ADPGK ADPGK GAPDH GAPDH OGDHL OGDHL HADHA HADHA TKFC TKFC ME1 ME1 PGAM1 PGAM1 MMUT MMUT PSAT1 PSAT1 HIBCH HIBCH ACSS2 ACSS2 DLD DLD MDH2 MDH2 GOT1 GOT1 PGLS PGLS HK3 HK3 CPS1 CPS1 PFKP PFKP ADH5 ADH5 MTHFR MTHFR PFKM PFKM PGD PGD HAO2 HAO2 CS CS GPT2 GPT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)
PFKLPhosphofructokinase, liver type. (803 aa)
HK1Hexokinase 1. (945 aa)
ME2Malic enzyme. (584 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
FHFumarate hydratase. (514 aa)
PGK2Phosphoglycerate kinase. (417 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
TKTL1Transketolase like 1. (596 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (318 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (733 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (900 aa)
GLYCTKGlycerate kinase. (523 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
PRPS1L1Phosphoribosyl pyrophosphate synthetase 1 like 1. (313 aa)
PSPHPhosphoserine phosphatase. (225 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (493 aa)
PGK1Phosphoglycerate kinase. (424 aa)
LOC108634030Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
HKDC1Hexokinase domain containing 1. (918 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (283 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
RGNRegucalcin. (301 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (535 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
SDSLSerine dehydratase like. (329 aa)
HK2Hexokinase 2. (917 aa)
ACADSAcyl-CoA dehydrogenase short chain. (412 aa)
LOC102181016Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
GOT2Aspartate aminotransferase. (430 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (323 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (810 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
ME3Malic enzyme. (604 aa)
TKTL2Transketolase like 2. (620 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (404 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
GCKPhosphotransferase. (465 aa)
MDH1Malate dehydrogenase. (334 aa)
ENO1Enolase 1. (434 aa)
TPI1Triosephosphate isomerase. (295 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
RPIARibose 5-phosphate isomerase A. (306 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (388 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
ACAT2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (350 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
LOC102173923Pribosyltran_N domain-containing protein. (318 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
ENO2Uncharacterized protein. (441 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
ENO4Enolase 4. (613 aa)
ENO3Enolase 3. (444 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
MCEEMethylmalonyl-CoA epimerase. (179 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (395 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (559 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (540 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
ESDS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
ACSS1Acetyl-coenzyme A synthetase. (675 aa)
TKTTransketolase. (623 aa)
SDSSerine dehydratase. (326 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1187 aa)
AGXTSerine--pyruvate aminotransferase. (414 aa)
ADPGKADP dependent glucokinase. (497 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
OGDHLOxoglutarate dehydrogenase like. (1009 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
TKFCTriokinase and FMN cyclase. (625 aa)
ME1Malic enzyme. (571 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
MMUTMethylmalonyl-CoA mutase. (771 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
MDH2Malate dehydrogenase. (338 aa)
GOT1Aspartate aminotransferase. (413 aa)
PGLS6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (265 aa)
HK3Hexokinase 3. (924 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (378 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (838 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (473 aa)
HAO2Hydroxyacid oxidase 2. (353 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (454 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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