STRINGSTRING
MAPK1 MAPK1 MAPK14 MAPK14 JUN JUN LOC108633189 LOC108633189 RB1 RB1 HRAS HRAS CDKN1A CDKN1A RAF1 RAF1 E2F2 E2F2 CARM1 CARM1 DLL3 DLL3 NCOR1 NCOR1 CCND1 CCND1 E2F3 E2F3 SHC3 SHC3 ADCY9 ADCY9 ESR2 ESR2 ADCY6 ADCY6 LOC102188874 LOC102188874 MAPK10 MAPK10 SP1 SP1 SHC1 SHC1 SHC4 SHC4 MAPK9 MAPK9 PTK2 PTK2 ESR1 ESR1 MAP2K2 MAP2K2 AKT2 AKT2 BAD BAD E2F1 E2F1 PIK3R3 PIK3R3 JAG2 JAG2 CDKN1B CDKN1B GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA MMP2 MMP2 BCL2 BCL2 BAX BAX PRKACA PRKACA MMP9 MMP9 NOTCH3 NOTCH3 NCOA3 NCOA3 CDKN2C CDKN2C SOS1 SOS1 IGF1 IGF1 PIK3CB PIK3CB MDM2 MDM2 MTOR MTOR PIK3CD PIK3CD CDK4 CDK4 EGFR EGFR ADCY4 ADCY4 JAG1 JAG1 ABCB11 ABCB11 PIK3R1 PIK3R1 GPER1 GPER1 NOTCH2 NOTCH2 HBEGF HBEGF ARAF ARAF ADCY5 ADCY5 NRAS NRAS AKT1 AKT1 ADCY2 ADCY2 MAPK13 MAPK13 IGF1R IGF1R MED1 MED1 PRKACB PRKACB ADCY1 ADCY1 TP53 TP53 ADCY7 ADCY7 AKT3 AKT3 FOS FOS MAPK8 MAPK8 SOS2 SOS2 ADCY3 ADCY3 ERBB2 ERBB2 ADCY8 ADCY8 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LOC108633189Uncharacterized protein. (241 aa)
RB1RB transcriptional corepressor 1. (931 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
E2F2E2F transcription factor 2. (437 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
DLL3Delta like canonical Notch ligand 3. (595 aa)
NCOR1Nuclear receptor corepressor 1. (2447 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
SHC3SHC adaptor protein 3. (592 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
ESR2Uncharacterized protein. (527 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1172 aa)
LOC102188874Uncharacterized protein. (394 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
SP1Uncharacterized protein. (786 aa)
SHC1SHC adaptor protein 1. (583 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
BADBCL2 associated agonist of cell death. (198 aa)
E2F1E2F transcription factor 1. (441 aa)
PIK3R3Uncharacterized protein. (461 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
MMP9Uncharacterized protein. (709 aa)
NOTCH3Notch receptor 3. (2332 aa)
NCOA3Nuclear receptor coactivator. (1471 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1083 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ABCB11ATP binding cassette subfamily B member 11. (1326 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
NOTCH2Notch receptor 2. (2471 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1230 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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