38 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	LOC108637289	Uncharacterized protein. (1326 aa)
	LOC102180841	Uncharacterized protein. (1218 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (585 aa)
	ABCC4	Uncharacterized protein. (1323 aa)
	GGH	Folate gamma-glutamyl hydrolase. (318 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1595 aa)
	ENSCHIP00000009106	Uncharacterized protein. (854 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	FOLR2	Folate receptor beta. (253 aa)
	LOC108637248	Uncharacterized protein. (1278 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	LOC102179751	Uncharacterized protein. (1268 aa)
	ABCC3	ATP binding cassette subfamily C member 3. (1529 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (571 aa)
	LOC102185549	Uncharacterized protein. (1122 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	LOC102187779	Uncharacterized protein. (1101 aa)
	LOC102181111	Uncharacterized protein. (1096 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	ENSCHIP00000022686	Uncharacterized protein. (479 aa)
	SLC46A1	Solute carrier family 46 member 1. (459 aa)
	FOLR1	Folate_rec domain-containing protein. (251 aa)
	LOC102173859	Uncharacterized protein. (820 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
	ABCC2	ATP binding cassette subfamily C member 2. (1557 aa)
	ABCC5	ATP binding cassette subfamily C member 5. (1445 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	SLC19A1	Solute carrier family 19 member 1. (508 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (659 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
	ABCG2	Breast cancer resistance protein. (658 aa)
	FOLR3	Folate_rec domain-containing protein. (258 aa)
	IZUMO1R	IZUMO1 receptor, JUNO. (243 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC1	ABCG2	ENSCHIP00000007189	ENSCHIP00000032841	ATP binding cassette subfamily C member 1.	Breast cancer resistance protein.	0.970
ABCC1	FPGS	ENSCHIP00000007189	ENSCHIP00000004710	ATP binding cassette subfamily C member 1.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.415
ABCC1	GART	ENSCHIP00000007189	ENSCHIP00000020540	ATP binding cassette subfamily C member 1.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.470
ABCC2	ABCG2	ENSCHIP00000028329	ENSCHIP00000032841	ATP binding cassette subfamily C member 2.	Breast cancer resistance protein.	0.987
ABCC3	ABCG2	ENSCHIP00000013755	ENSCHIP00000032841	ATP binding cassette subfamily C member 3.	Breast cancer resistance protein.	0.533
ABCC4	ABCG2	ENSCHIP00000005598	ENSCHIP00000032841	Uncharacterized protein.	Breast cancer resistance protein.	0.528
ABCC5	ABCG2	ENSCHIP00000029124	ENSCHIP00000032841	ATP binding cassette subfamily C member 5.	Breast cancer resistance protein.	0.528
ABCC5	FPGS	ENSCHIP00000029124	ENSCHIP00000004710	ATP binding cassette subfamily C member 5.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.445
ABCG2	ABCC1	ENSCHIP00000032841	ENSCHIP00000007189	Breast cancer resistance protein.	ATP binding cassette subfamily C member 1.	0.970
ABCG2	ABCC2	ENSCHIP00000032841	ENSCHIP00000028329	Breast cancer resistance protein.	ATP binding cassette subfamily C member 2.	0.987
ABCG2	ABCC3	ENSCHIP00000032841	ENSCHIP00000013755	Breast cancer resistance protein.	ATP binding cassette subfamily C member 3.	0.533
ABCG2	ABCC4	ENSCHIP00000032841	ENSCHIP00000005598	Breast cancer resistance protein.	Uncharacterized protein.	0.528
ABCG2	ABCC5	ENSCHIP00000032841	ENSCHIP00000029124	Breast cancer resistance protein.	ATP binding cassette subfamily C member 5.	0.528
ATIC	DHFR	ENSCHIP00000019751	ENSCHIP00000015609	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.949
ATIC	FPGS	ENSCHIP00000019751	ENSCHIP00000004710	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.484
ATIC	GART	ENSCHIP00000019751	ENSCHIP00000020540	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
ATIC	GGH	ENSCHIP00000019751	ENSCHIP00000005957	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Folate gamma-glutamyl hydrolase.	0.457
ATIC	MTHFR	ENSCHIP00000019751	ENSCHIP00000031461	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.499
ATIC	SHMT1	ENSCHIP00000019751	ENSCHIP00000011211	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.990
ATIC	SHMT2	ENSCHIP00000019751	ENSCHIP00000001693	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.990