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| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa) |
| | PPP2R3B | Protein phosphatase 2 regulatory subunit B''beta. (664 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (350 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa) |
| | CERS4 | Ceramide synthase 4. (393 aa) |
| | TRAF2 | TNF receptor-associated factor. (497 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (549 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa) |
| | ADORA3 | Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (317 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (400 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1150 aa) |
| | GNAI2 | G protein subunit alpha i2. (357 aa) |
| | PLD1 | Phospholipase. (1189 aa) |
| | S1PR2 | Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1595 aa) |
| | CERS5 | Uncharacterized protein. (415 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | KNG1 | Kininogen 1. (619 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (260 aa) |
| | S1PR4 | Sphingosine-1-phosphate receptor 4. (385 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (426 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (449 aa) |
| | S1PR5 | Sphingosine-1-phosphate receptor 5. (398 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa) |
| | RHOA | Ras-like protein family member A. (193 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | BID | Uncharacterized protein. (244 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (571 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (557 aa) |
| | ASAH2 | Neutral ceramidase. (770 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | NSMAF | Neutral sphingomyelinase activation associated factor. (920 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | BCL2 | BH4_2 domain-containing protein. (229 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (480 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa) |
| | GAB2 | GRB2 associated binding protein 2. (680 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (492 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (365 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa) |
| | PRKCE | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (590 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (615 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (445 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (323 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (619 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (418 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (359 aa) |
| | CERS1 | TLC domain-containing protein. (333 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | SPHK1 | Sphingosine kinase 1. (392 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (399 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (562 aa) |
| | S1PR3 | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (598 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) |
| | SPHK2 | Sphingosine kinase 2. (653 aa) |
| | GNA12 | G protein subunit alpha 12. (382 aa) |
| | PRKCA | Uncharacterized protein. (605 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | CERS3 | Ceramide synthase 3. (387 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (442 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (243 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
