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LOC102176379 | Wee1-like protein kinase. (549 aa) | ||||
CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa) | ||||
TFDP1 | Transcription factor. (410 aa) | ||||
SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) | ||||
TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) | ||||
LOC102174738 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) | ||||
RB1 | RB transcriptional corepressor 1. (931 aa) | ||||
ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (843 aa) | ||||
CDKN1A | Cyclin dependent kinase inhibitor 1A. (161 aa) | ||||
LOC102188771 | Zf-rbx1 domain-containing protein. (108 aa) | ||||
E2F2 | E2F transcription factor 2. (437 aa) | ||||
ANAPC5 | Anaphase promoting complex subunit 5. (747 aa) | ||||
SMC1A | Structural maintenance of chromosomes protein. (1188 aa) | ||||
CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa) | ||||
TFDP2 | Transcription factor Dp-2. (451 aa) | ||||
CDC14C | Cell division cycle 14C. (485 aa) | ||||
TTK | TTK protein kinase. (852 aa) | ||||
RBL1 | RB transcriptional corepressor like 1. (1068 aa) | ||||
CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) | ||||
RAD21 | RAD21 cohesin complex component. (630 aa) | ||||
E2F3 | E2F_TDP domain-containing protein. (460 aa) | ||||
SMC3 | Structural maintenance of chromosomes protein. (1231 aa) | ||||
MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) | ||||
CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) | ||||
ZBTB17 | Zinc finger and BTB domain containing 17. (833 aa) | ||||
GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa) | ||||
CCNB3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1301 aa) | ||||
CDKN1C | Cyclin dependent kinase inhibitor 1C. (254 aa) | ||||
YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) | ||||
E2F5 | E2F transcription factor 5. (314 aa) | ||||
ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) | ||||
CDC26 | Cell division cycle 26. (85 aa) | ||||
MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) | ||||
SMAD3 | Mothers against decapentaplegic homolog. (425 aa) | ||||
CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) | ||||
ANAPC11 | RING-type domain-containing protein. (84 aa) | ||||
PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa) | ||||
STAG1 | Stromal antigen 1. (1279 aa) | ||||
CDC14A | Cell division cycle 14A. (627 aa) | ||||
GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) | ||||
CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) | ||||
FZR1 | Fizzy and cell division cycle 20 related 1. (513 aa) | ||||
ESPL1 | Extra spindle pole bodies like 1, separase. (2101 aa) | ||||
E2F1 | E2F transcription factor 1. (441 aa) | ||||
YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) | ||||
BUB1B | Uncharacterized protein. (1062 aa) | ||||
YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) | ||||
CCNB1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa) | ||||
GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) | ||||
ORC5 | Origin recognition complex subunit 5. (435 aa) | ||||
WEE1 | Wee1-like protein kinase. (645 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) | ||||
CREBBP | CREB binding protein. (2435 aa) | ||||
CCNA2 | Cyclin A2; Belongs to the cyclin family. (430 aa) | ||||
EP300 | E1A binding protein p300. (2411 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (851 aa) | ||||
CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) | ||||
WEE2 | Wee1-like protein kinase. (566 aa) | ||||
SKP2 | F-box domain-containing protein. (424 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (1061 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) | ||||
CDC27 | Cell division cycle 27. (824 aa) | ||||
CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) | ||||
CDC20 | WD_REPEATS_REGION domain-containing protein. (499 aa) | ||||
ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) | ||||
SMAD2 | Mothers against decapentaplegic homolog. (467 aa) | ||||
YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family. (245 aa) | ||||
MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) | ||||
ANAPC13 | Anaphase promoting complex subunit 13. (74 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa) | ||||
CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) | ||||
DBF4 | DBF4 zinc finger. (675 aa) | ||||
BUB3 | BUB3 mitotic checkpoint protein. (328 aa) | ||||
ORC2 | Origin recognition complex subunit 2. (596 aa) | ||||
ANAPC1 | Anaphase promoting complex subunit 1. (1905 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1151 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
ORC6 | Origin recognition complex subunit 6. (252 aa) | ||||
TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) | ||||
CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) | ||||
PLK1 | Serine/threonine-protein kinase PLK. (602 aa) | ||||
YWHAE | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa) | ||||
CHEK2 | Checkpoint kinase 2. (534 aa) | ||||
CDC25A | Cell division cycle 25A. (517 aa) | ||||
ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa) | ||||
ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) | ||||
CCNH | Cyclin H; Belongs to the cyclin family. (329 aa) | ||||
CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa) | ||||
ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) | ||||
ORC3 | Origin recognition complex subunit 3. (712 aa) | ||||
HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) | ||||
CDC16 | Cell division cycle 16. (620 aa) | ||||
CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) | ||||
RBL2 | RB transcriptional corepressor like 2. (1140 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) | ||||
MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) | ||||
CDC23 | Cell division cycle 23. (597 aa) | ||||
CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) | ||||
CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) | ||||
STAG2 | Stromal antigen 2. (1268 aa) | ||||
GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) | ||||
YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) | ||||
RBX1 | RING-type domain-containing protein. (108 aa) | ||||
CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) | ||||
CUL1 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa) | ||||
CDC7 | Cell division cycle 7. (576 aa) | ||||
CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) | ||||
PTTG1 | Uncharacterized protein. (202 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |