73 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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	AIFM2	Apoptosis inducing factor mitochondria associated 2. (373 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (344 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (294 aa)
	RPRM	Reprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (332 aa)
	LOC102180219	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (279 aa)
	SHISA5	Shisa family member 5. (218 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (389 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (261 aa)
	BBC3	Uncharacterized protein. (193 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	ENSCHIP00000012455	TNFR-Cys domain-containing protein. (161 aa)
	BID	Uncharacterized protein. (244 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	PERP	P53 apoptosis effector related to PMP22. (184 aa)
	LOC108634246	Uncharacterized protein. (215 aa)
	CD82	Tetraspanin. (265 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	CCNB1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	GTSE1	GTSE1_N domain-containing protein. (725 aa)
	ENSCHIP00000015988	Uncharacterized protein. (157 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	COP1	COP1 E3 ubiquitin ligase. (739 aa)
	THBS1	Thrombospondin 1. (1218 aa)
	SESN1	Sestrin 1. (552 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1560 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (488 aa)
	GORAB	Golgin, RAB6 interacting. (370 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
	STEAP3	STEAP3 metalloreductase. (521 aa)
	EI24	Uncharacterized protein. (340 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	PIDD1	P53-induced death domain protein 1. (913 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (176 aa)
	LOC102175959	Uncharacterized protein. (292 aa)
	DDB2	Damage specific DNA binding protein 2. (411 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
	ENSCHIP00000025610	TNFR-Cys domain-containing protein. (164 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	CHEK2	Checkpoint kinase 2. (534 aa)
	SESN2	Sestrin 2. (471 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	BCL2L1	BH4_2 domain-containing protein. (233 aa)
	IGFBP3	Uncharacterized protein. (293 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (411 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	ZMAT3	Zinc finger matrin-type 3. (288 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	SESN3	Sestrin 3. (492 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	LOC102173997	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	LOC106501717	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRB1	RPRM	ENSCHIP00000020126	ENSCHIP00000002305	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family.	Reprimo, TP53 dependent G2 arrest mediator homolog.	0.434
AIFM2	TP53	ENSCHIP00000000110	ENSCHIP00000030141	Apoptosis inducing factor mitochondria associated 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.541
APAF1	ATM	ENSCHIP00000031955	ENSCHIP00000016363	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.543
APAF1	BAX	ENSCHIP00000031955	ENSCHIP00000016021	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.671
APAF1	BCL2	ENSCHIP00000031955	ENSCHIP00000015831	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH4_2 domain-containing protein.	0.957
APAF1	BCL2L1	ENSCHIP00000031955	ENSCHIP00000028787	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH4_2 domain-containing protein.	0.641
APAF1	BID	ENSCHIP00000031955	ENSCHIP00000012715	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.580
APAF1	CASP3	ENSCHIP00000031955	ENSCHIP00000011490	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.997
APAF1	CASP8	ENSCHIP00000031955	ENSCHIP00000020513	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.974
APAF1	CASP9	ENSCHIP00000031955	ENSCHIP00000008590	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CCND1	ENSCHIP00000031955	ENSCHIP00000006815	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cyclin D1; Belongs to the cyclin family.	0.511
APAF1	CDK1	ENSCHIP00000031955	ENSCHIP00000000505	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.428
APAF1	CDK4	ENSCHIP00000031955	ENSCHIP00000022710	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.402
APAF1	CDK6	ENSCHIP00000031955	ENSCHIP00000008415	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.419
APAF1	DDB2	ENSCHIP00000031955	ENSCHIP00000024487	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Damage specific DNA binding protein 2.	0.524
APAF1	LOC102173997	ENSCHIP00000031955	ENSCHIP00000031546	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC102175959	ENSCHIP00000031955	ENSCHIP00000024233	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.416
APAF1	LOC106501717	ENSCHIP00000031955	ENSCHIP00000032023	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	MDM2	ENSCHIP00000031955	ENSCHIP00000021696	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.519
APAF1	PIDD1	ENSCHIP00000031955	ENSCHIP00000023138	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53-induced death domain protein 1.	0.569