STRINGSTRING
AIFM1 AIFM1 PRF1 PRF1 MAPK1 MAPK1 LOC102187765 LOC102187765 TUBA4A TUBA4A JUN JUN CTSF CTSF HRAS HRAS CTSD CTSD CTSW CTSW TRAF2 TRAF2 DAB2IP DAB2IP RAF1 RAF1 NGF NGF FADD FADD NFKB1 NFKB1 ITPR3 ITPR3 HRK HRK CTSV CTSV NFKBIA NFKBIA BBC3 BBC3 DFFB DFFB EIF2S1 EIF2S1 CTSZ CTSZ SPTA1 SPTA1 CASP7 CASP7 CTSK CTSK CASP9 CASP9 CSF2RB CSF2RB GADD45B GADD45B XIAP XIAP DDIT3 DDIT3 CASP6 CASP6 BIRC3 BIRC3 MAPK10 MAPK10 HTRA2 HTRA2 TNFRSF1A TNFRSF1A BIRC5 BIRC5 ACTB ACTB LMNB2 LMNB2 SPTAN1 SPTAN1 LMNB1 LMNB1 CASP3 CASP3 CTSC CTSC DAXX DAXX MAPK9 MAPK9 BCL2A1 BCL2A1 ENSCHIP00000012455 ENSCHIP00000012455 IKBKB IKBKB BID BID LOC102176878 LOC102176878 EIF2AK3 EIF2AK3 ATF4 ATF4 MAP2K2 MAP2K2 CTSO CTSO DFFA DFFA RELA RELA AKT2 AKT2 PDPK1 PDPK1 LOC108634246 LOC108634246 BAD BAD PIK3R3 PIK3R3 LOC108636199 LOC108636199 PMAIP1 PMAIP1 PARP3 PARP3 PARP4 PARP4 MAPK3 MAPK3 PIK3CA PIK3CA LOC102175759 LOC102175759 LOC102168343 LOC102168343 BAK1 BAK1 BCL2 BCL2 ENSCHIP00000015988 ENSCHIP00000015988 BAX BAX CFLAR CFLAR GADD45G GADD45G ATM ATM ITPR2 ITPR2 TNFSF10 TNFSF10 DIABLO DIABLO CHUK CHUK MAP3K14 MAP3K14 BIRC2 BIRC2 LOC102190507 LOC102190507 LOC102177285 LOC102177285 TUBA1B TUBA1B PARP1 PARP1 CAPN2 CAPN2 ITPR1 ITPR1 LOC102173837 LOC102173837 CASP8 CASP8 TRAF1 TRAF1 TUBAL3 TUBAL3 LOC102178119 LOC102178119 PIK3CB PIK3CB BCL2L11 BCL2L11 PIK3CD PIK3CD LOC102176598 LOC102176598 LOC108633178 LOC108633178 LOC102190602 LOC102190602 ENDOG ENDOG PIDD1 PIDD1 CTSL CTSL PTPN13 PTPN13 PIK3R1 PIK3R1 LOC102175959 LOC102175959 LOC108638467 LOC108638467 ENSCHIP00000025610 ENSCHIP00000025610 LOC108638461 LOC108638461 CAPN1 CAPN1 FASLG FASLG CTSS CTSS LMNA LMNA TUBA1A TUBA1A TUBA8 TUBA8 NRAS NRAS NTRK1 NTRK1 AKT1 AKT1 IKBKG IKBKG MAP3K5 MAP3K5 BCL2L1 BCL2L1 SEPTIN4 SEPTIN4 TRADD TRADD TP53 TP53 TUBA1C TUBA1C AKT3 AKT3 FOS FOS CTSB CTSB GADD45A GADD45A MAPK8 MAPK8 LOC102173997 LOC102173997 ERN1 ERN1 CTSH CTSH APAF1 APAF1 LOC106501717 LOC106501717 RIPK1 RIPK1 KRAS KRAS MCL1 MCL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
PRF1Perforin 1. (554 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
LOC102187765Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (498 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (455 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
CTSFUncharacterized protein; Belongs to the peptidase C1 family. (460 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (375 aa)
TRAF2TNF receptor-associated factor. (497 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2653 aa)
HRKActivator of apoptosis harakiri; Promotes apoptosis. (91 aa)
CTSVUncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
BBC3Uncharacterized protein. (193 aa)
DFFBDNA fragmentation factor subunit beta. (370 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (304 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2402 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (890 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (275 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
BIRC5Uncharacterized protein. (142 aa)
ACTBUncharacterized protein. (375 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (641 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1. (2452 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
DAXXDaxx domain-containing protein. (737 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BCL2A1BCL2 related protein A1. (175 aa)
ENSCHIP00000012455TNFR-Cys domain-containing protein. (161 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BIDUncharacterized protein. (244 aa)
LOC102176878Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
ATF4Activating transcription factor 4. (352 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (309 aa)
DFFACIDE-N domain-containing protein. (329 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
LOC108634246Uncharacterized protein. (215 aa)
BADBCL2 associated agonist of cell death. (198 aa)
PIK3R3Uncharacterized protein. (461 aa)
LOC108636199Daxx domain-containing protein. (716 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
PARP4Poly [ADP-ribose] polymerase. (1739 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102175759Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
LOC102168343Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ENSCHIP00000015988Uncharacterized protein. (157 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (484 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
DIABLOUncharacterized protein. (238 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
BIRC2Baculoviral IAP repeat containing 2. (623 aa)
LOC102190507Uncharacterized protein. (139 aa)
LOC102177285Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
LOC102173837Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (470 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
TRAF1TNF receptor-associated factor. (410 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
LOC102178119Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC102176598Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
LOC108633178Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
LOC102190602Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
ENDOGEndonuclease. (299 aa)
PIDD1P53-induced death domain protein 1. (913 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2462 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC102175959Uncharacterized protein. (292 aa)
LOC108638467Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
ENSCHIP00000025610TNFR-Cys domain-containing protein. (164 aa)
LOC108638461Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (744 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (477 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (493 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
SEPTIN4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (335 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (955 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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