STRINGSTRING
AIFM1 AIFM1 MACROH2A2 MACROH2A2 GLUD1 GLUD1 LOC108635529 LOC108635529 LOC108636634 LOC108636634 LOC108633243 LOC108633243 CHMP6 CHMP6 JAK2 JAK2 VPS4B VPS4B H2AC6 H2AC6 LOC102179943 LOC102179943 CHMP4C CHMP4C H2AC21 H2AC21 TRAF2 TRAF2 ZBP1 ZBP1 SLC25A5 SLC25A5 H2AJ H2AJ LOC102178870 LOC102178870 FADD FADD LOC108636544 LOC108636544 LOC106503501 LOC106503501 IFNA IFNA JAK3 JAK3 PLA2G4F PLA2G4F LOC102174842 LOC102174842 ENSCHIP00000005711 ENSCHIP00000005711 STAT1 STAT1 CAMK2D CAMK2D LOC108636627 LOC108636627 LOC108636629 LOC108636629 CAMK2G CAMK2G LOC102171676 LOC102171676 LOC102181867 LOC102181867 LOC102172435 LOC102172435 PPID PPID LOC102180761 LOC102180761 CHMP2A CHMP2A VPS4A VPS4A TICAM2 TICAM2 PYGM PYGM XIAP XIAP SLC25A6 SLC25A6 BIRC3 BIRC3 LOC108636632 LOC108636632 H2AX H2AX MAPK10 MAPK10 CYBB CYBB JAK1 JAK1 TNFRSF1A TNFRSF1A TRPM7 TRPM7 LOC102181595 LOC102181595 VDAC2 VDAC2 IFNGR1 IFNGR1 MAPK9 MAPK9 CHMP2B CHMP2B ENSCHIP00000012455 ENSCHIP00000012455 BID BID CHMP4B CHMP4B LOC108634246 LOC108634246 TLR3 TLR3 IRF9 IRF9 STAT2 STAT2 BCL2 BCL2 EIF2AK2 EIF2AK2 ENSCHIP00000015988 ENSCHIP00000015988 BAX BAX CFLAR CFLAR IFNG IFNG RIPK3 RIPK3 TRAF5 TRAF5 TNFSF10 TNFSF10 SPATA2L SPATA2L SPATA2 SPATA2 BIRC2 BIRC2 IFNGR2 IFNGR2 SLC25A31 SLC25A31 HSP90AB1 HSP90AB1 IFNAR1 IFNAR1 LOC102178853 LOC102178853 PARP1 PARP1 USP21 USP21 CAPN2 CAPN2 HMGB1 HMGB1 TLR4 TLR4 LOC102183306 LOC102183306 TYK2 TYK2 PGAM5 PGAM5 FTH1 FTH1 LOC108633160 LOC108633160 CASP8 CASP8 MLKL MLKL IFNAR2 IFNAR2 IL33 IL33 STAT3 STAT3 CHMP4A CHMP4A VDAC3 VDAC3 STAT4 STAT4 SMPD1 SMPD1 TICAM1 TICAM1 MACROH2A1 MACROH2A1 TNFAIP3 TNFAIP3 LOC102175959 LOC102175959 STAT5B STAT5B STAT5A STAT5A ENSCHIP00000025610 ENSCHIP00000025610 HSP90AA1 HSP90AA1 PPIA PPIA CAPN1 CAPN1 FASLG FASLG SQSTM1 SQSTM1 PYCARD PYCARD NLRP3 NLRP3 H2AZ2 H2AZ2 FAF1 FAF1 VDAC1 VDAC1 IL1B IL1B SHARPIN SHARPIN CHMP7 CHMP7 TRADD TRADD FTL FTL CAMK2A CAMK2A GLUL GLUL CHMP1A CHMP1A MAPK8 MAPK8 ALOX15 ALOX15 STAT6 STAT6 PYGB PYGB PLA2G4A PLA2G4A CYLD CYLD ENSCHIP00000032473 ENSCHIP00000032473 RBCK1 RBCK1 RIPK1 RIPK1 CHMP5 CHMP5 SLC25A4 SLC25A4 PYGL PYGL RNF31 RNF31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)
LOC108635529Uncharacterized protein. (189 aa)
LOC108636634Uncharacterized protein. (186 aa)
LOC108633243Uncharacterized protein. (186 aa)
CHMP6Charged multivesicular body protein 6. (213 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC102179943Uncharacterized protein. (189 aa)
CHMP4CCharged multivesicular body protein 4C. (236 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
TRAF2TNF receptor-associated factor. (497 aa)
ZBP1Uncharacterized protein. (427 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC102178870Histone H2A; Belongs to the histone H2A family. (130 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
LOC108636544Uncharacterized protein. (186 aa)
LOC106503501Histone H2A; Belongs to the histone H2A family. (130 aa)
IFNAUncharacterized protein. (189 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
PLA2G4FPhospholipase A2. (830 aa)
LOC102174842Uncharacterized protein. (189 aa)
ENSCHIP00000005711Histone H2A; Belongs to the histone H2A family. (96 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
CAMK2DProtein kinase domain-containing protein. (532 aa)
LOC108636627Uncharacterized protein. (189 aa)
LOC108636629Uncharacterized protein. (186 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (577 aa)
LOC102171676Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC102181867Uncharacterized protein. (186 aa)
LOC102172435Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
PPIDUncharacterized protein. (370 aa)
LOC102180761Uncharacterized protein. (189 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (442 aa)
TICAM2TIR domain-containing protein. (232 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (857 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
LOC108636632Uncharacterized protein. (186 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
LOC102181595Uncharacterized protein. (186 aa)
VDAC2Voltage dependent anion channel 2. (294 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CHMP2BCharged multivesicular body protein 2B. (226 aa)
ENSCHIP00000012455TNFR-Cys domain-containing protein. (161 aa)
BIDUncharacterized protein. (244 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
LOC108634246Uncharacterized protein. (215 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
IRF9Interferon regulatory factor 9. (470 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (543 aa)
ENSCHIP00000015988Uncharacterized protein. (157 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (484 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
RIPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
SPATA2LSpermatogenesis associated 2 like. (409 aa)
SPATA2Spermatogenesis associated 2. (516 aa)
BIRC2Baculoviral IAP repeat containing 2. (623 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
LOC102178853Uncharacterized protein. (672 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
HMGB1Uncharacterized protein. (215 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
LOC102183306Histone H2A; Belongs to the histone H2A family. (128 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
LOC108633160Uncharacterized protein. (189 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
IFNAR2Uncharacterized protein. (534 aa)
IL33Interleukin 33. (274 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CHMP4ACharged multivesicular body protein 4A. (222 aa)
VDAC3Uncharacterized protein. (283 aa)
STAT4Signal transducer and activator of transcription. (797 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (619 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (786 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
TNFAIP3TNF alpha induced protein 3. (785 aa)
LOC102175959Uncharacterized protein. (292 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
ENSCHIP00000025610TNFR-Cys domain-containing protein. (164 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (744 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
SQSTM1Sequestosome 1. (440 aa)
PYCARDPYD and CARD domain containing. (196 aa)
NLRP3NLR family, pyrin domain containing 3. (1031 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (127 aa)
FAF1Fas associated factor 1. (675 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
SHARPINSHANK associated RH domain interactor. (501 aa)
CHMP7Uncharacterized protein. (450 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GLULGlutamine synthetase. (373 aa)
CHMP1ACharged multivesicular body protein 1A. (247 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (846 aa)
PLA2G4APhospholipase A2. (740 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
ENSCHIP00000032473Uncharacterized protein. (189 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
RNF31Uncharacterized protein. (1066 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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