STRINGSTRING
PPP3CB PPP3CB MAPK1 MAPK1 MAPK14 MAPK14 SOCS1 SOCS1 LOC108636634 LOC108636634 LOC108633243 LOC108633243 FOSB FOSB JUN JUN PPP3R1 PPP3R1 TRAF2 TRAF2 JUNB JUNB TREM2 TREM2 LOC102185698 LOC102185698 LOC108636544 LOC108636544 NFKB1 NFKB1 FYN FYN STAT1 STAT1 LOC108636629 LOC108636629 NFKBIA NFKBIA FOSL2 FOSL2 LOC102181867 LOC102181867 SOCS3 SOCS3 TGFBR2 TGFBR2 CTSK CTSK MAP3K7 MAP3K7 TGFB1 TGFB1 CAMK4 CAMK4 SYK SYK LOC108636632 LOC108636632 MAPK10 MAPK10 SIRPA SIRPA NCF4 NCF4 RELB RELB JAK1 JAK1 TNFRSF1A TNFRSF1A IL1R1 IL1R1 LOC102181595 LOC102181595 IFNGR1 IFNGR1 LCK LCK MAPK9 MAPK9 ENSCHIP00000012347 ENSCHIP00000012347 IKBKB IKBKB ACP5 ACP5 CYBA CYBA PPP3CC PPP3CC TAB1 TAB1 TNFSF11 TNFSF11 RELA RELA AKT2 AKT2 PIK3R3 PIK3R3 IRF9 IRF9 TRAF6 TRAF6 PPARG PPARG GRB2 GRB2 STAT2 STAT2 MAPK3 MAPK3 PIK3CA PIK3CA IFNG IFNG CHUK CHUK MAP3K14 MAP3K14 PLCG2 PLCG2 GAB2 GAB2 IFNGR2 IFNGR2 ITGB3 ITGB3 IFNAR1 IFNAR1 TYK2 TYK2 NOX1 NOX1 PIK3CB PIK3CB SPI1 SPI1 IFNAR2 IFNAR2 NFKB2 NFKB2 PIK3CD PIK3CD OSCAR OSCAR NFATC1 NFATC1 TAB2 TAB2 PIK3R1 PIK3R1 BTK BTK MAP2K7 MAP2K7 MITF MITF NCF1 NCF1 TGFBR1 TGFBR1 TGFB2 TGFB2 TEC TEC FOSL1 FOSL1 SQSTM1 SQSTM1 AKT1 AKT1 IKBKG IKBKG MAPK13 MAPK13 IL1B IL1B TNFRSF11B TNFRSF11B FHL2 FHL2 AKT3 AKT3 FOS FOS MAPK8 MAPK8 TNFRSF11A TNFRSF11A CYLD CYLD PPP3CA PPP3CA CSF1R CSF1R CSF1 CSF1 LOC102173987 LOC102173987 CREB1 CREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CBSerine/threonine-protein phosphatase. (535 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
SOCS1Suppressor of cytokine signaling 1. (219 aa)
LOC108636634Uncharacterized protein. (186 aa)
LOC108633243Uncharacterized protein. (186 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PPP3R1Uncharacterized protein. (170 aa)
TRAF2TNF receptor-associated factor. (497 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC102185698Uncharacterized protein. (250 aa)
LOC108636544Uncharacterized protein. (186 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FYNTyrosine-protein kinase. (537 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
LOC108636629Uncharacterized protein. (186 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
LOC102181867Uncharacterized protein. (186 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (464 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
LOC108636632Uncharacterized protein. (186 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
SIRPAUncharacterized protein. (506 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
RELBRELB proto-oncogene, NF-kB subunit. (645 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
LOC102181595Uncharacterized protein. (186 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
LCKTyrosine-protein kinase. (509 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSCHIP00000012347Uncharacterized protein. (407 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRF9Interferon regulatory factor 9. (470 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
GAB2GRB2 associated binding protein 2. (680 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (786 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
NOX1NADPH oxidase 1. (498 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
IFNAR2Uncharacterized protein. (534 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
OSCAROsteoclast associated Ig-like receptor. (257 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BTKTyrosine-protein kinase. (658 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (558 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TECTyrosine-protein kinase. (632 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SQSTM1Sequestosome 1. (440 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
FHL2Four and a half LIM domains 2. (279 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
TNFRSF11ATNF receptor superfamily member 11a. (588 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
LOC102173987Uncharacterized protein. (349 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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