STRINGSTRING
MAPK1 MAPK1 NODAL NODAL BMPR1A BMPR1A MAPK14 MAPK14 WNT8A WNT8A FZD9 FZD9 KAT6A KAT6A HAND1 HAND1 JAK2 JAK2 HRAS HRAS RAF1 RAF1 JARID2 JARID2 FZD5 FZD5 IL6ST IL6ST FZD10 FZD10 SKIL SKIL DLX5 DLX5 WNT2B WNT2B JAK3 JAK3 PCGF1 PCGF1 WNT9A WNT9A AXIN1 AXIN1 LOC102183990 LOC102183990 SETDB1 SETDB1 WNT10B WNT10B WNT2 WNT2 ID1 ID1 SOX2 SOX2 SMAD1 SMAD1 PCGF6 PCGF6 NANOG NANOG TBX3 TBX3 FZD1 FZD1 TCF3 TCF3 DUSP9 DUSP9 JAK1 JAK1 SMARCAD1 SMARCAD1 DVL3 DVL3 ACVR1C ACVR1C ACVR2B ACVR2B ACVR2A ACVR2A NEUROG1 NEUROG1 MYC MYC SMAD3 SMAD3 LIF LIF LIFR LIFR WNT5B WNT5B GSK3B GSK3B WNT7B WNT7B SMAD5 SMAD5 MAP2K2 MAP2K2 MYF5 MYF5 AKT2 AKT2 REST REST PIK3R3 PIK3R3 GRB2 GRB2 MAPK3 MAPK3 WNT5A WNT5A PIK3CA PIK3CA WNT3A WNT3A WNT16 WNT16 BMI1 BMI1 APC2 APC2 KLF4 KLF4 FZD6 FZD6 LOC102183441 LOC102183441 HOXD1 HOXD1 INHBC INHBC BMPR1B BMPR1B HOXB1 HOXB1 OTX1 OTX1 FGFR2 FGFR2 FGF2 FGF2 ONECUT1 ONECUT1 ID2 ID2 ACVR1B ACVR1B ZFHX3 ZFHX3 WNT3 WNT3 PCGF2 PCGF2 IGF1 IGF1 WNT1 WNT1 PIK3CB PIK3CB SMAD2 SMAD2 PIK3CD PIK3CD BMPR2 BMPR2 STAT3 STAT3 RIF1 RIF1 PCGF5 PCGF5 AXIN2 AXIN2 BMP4 BMP4 PIK3R1 PIK3R1 POU5F1 POU5F1 ZIC3 ZIC3 WNT11 WNT11 WNT8B WNT8B WNT7A WNT7A INHBE INHBE ISL1 ISL1 ACVR1 ACVR1 ESRRB ESRRB WNT10A WNT10A LHX5 LHX5 NRAS NRAS AKT1 AKT1 PAX6 PAX6 WNT6 WNT6 FGFR4 FGFR4 FZD3 FZD3 MAPK13 MAPK13 HESX1 HESX1 HOXA1 HOXA1 IGF1R IGF1R ID3 ID3 INHBB INHBB APC APC AKT3 AKT3 CTNNB1 CTNNB1 DVL2 DVL2 INHBA INHBA FZD4 FZD4 FZD7 FZD7 WNT4 WNT4 KRAS KRAS FZD8 FZD8 WNT9B WNT9B TCF7 TCF7 MEIS1 MEIS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
NODALNodal growth differentiation factor. (346 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1993 aa)
HAND1Heart and neural crest derivatives expressed 1. (219 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1258 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (684 aa)
DLX5Distal-less homeobox 5. (289 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
AXIN1Axin 1. (867 aa)
LOC102183990Left-right determination factor. (367 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1287 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SOX2HMG box domain-containing protein. (320 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PCGF6Polycomb group ring finger 6. (354 aa)
NANOGHomeobox domain-containing protein. (300 aa)
TBX3T-box transcription factor 3. (749 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
TCF3Transcription factor 3. (642 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (380 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (522 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
NEUROG1Neurogenin 1. (246 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
LIFRLIF receptor subunit alpha. (1066 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
RESTUncharacterized protein. (998 aa)
PIK3R3Uncharacterized protein. (461 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
BMI1RING-type domain-containing protein. (437 aa)
APC2APC regulator of WNT signaling pathway 2. (2305 aa)
KLF4Kruppel like factor 4. (510 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
LOC102183441Left-right determination factor. (367 aa)
HOXD1Homeobox D1. (322 aa)
INHBCInhibin subunit beta C. (352 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
HOXB1Homeobox B1. (302 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ONECUT1One cut domain family member. (464 aa)
ID2BHLH domain-containing protein. (134 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ZFHX3Zinc finger homeobox 3. (3707 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
AXIN2Axin 2. (844 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
POU5F1POU domain protein. (360 aa)
ZIC3Zic family member 3. (465 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
INHBEInhibin subunit beta E. (348 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ESRRBEstrogen related receptor beta. (454 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
LHX5LIM homeobox 5. (402 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PAX6Paired box 6. (486 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
HESX1HESX homeobox 1. (185 aa)
HOXA1Homeobox A1. (333 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (151 aa)
INHBBInhibin subunit beta B. (408 aa)
APCAPC regulator of WNT signaling pathway. (2880 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CTNNB1Catenin beta 1. (781 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
INHBAInhibin beta A subunit. (425 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (665 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
TCF7Transcription factor 7. (418 aa)
MEIS1Meis homeobox 1. (465 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.