STRINGSTRING
CRLF2 CRLF2 CSF2RA CSF2RA LOC108634973 LOC108634973 LOC108636617 LOC108636617 SOCS1 SOCS1 LOC108635529 LOC108635529 LOC108636634 LOC108636634 SOCS5 SOCS5 LOC102180392 LOC102180392 LOC108633243 LOC108633243 JAK2 JAK2 STAM STAM HRAS HRAS LOC108636616 LOC108636616 PDGFRA PDGFRA LOC102179943 LOC102179943 CDKN1A CDKN1A IL2RG IL2RG CSF3R CSF3R RAF1 RAF1 IL6ST IL6ST IFNE IFNE LOC108636544 LOC108636544 LOC108634604 LOC108634604 SOCS4 SOCS4 LOC108636623 LOC108636623 IFNA IFNA JAK3 JAK3 OSMR OSMR LOC102174842 LOC102174842 LOC108636618 LOC108636618 IL2RA IL2RA LOC108636628 LOC108636628 IL11RA IL11RA STAT1 STAT1 IL13RA1 IL13RA1 LOC108635000 LOC108635000 LOC108636627 LOC108636627 PIAS3 PIAS3 LOC108636629 LOC108636629 LOC108636626 LOC108636626 LOC102181867 LOC102181867 CNTFR CNTFR CCND1 CCND1 CNTF CNTF PRLR PRLR IL23A IL23A PRP6 PRP6 LOC102180761 LOC102180761 SOCS3 SOCS3 GH1 GH1 IL5RA IL5RA CSF2RB CSF2RB IL6 IL6 LOC108636632 LOC108636632 IL20 IL20 LOC102170569 LOC102170569 IL15RA IL15RA LOC108636620 LOC108636620 JAK1 JAK1 LOC102184390 LOC102184390 IL10RA IL10RA LOC102181595 LOC102181595 IL7 IL7 LOC102190477 LOC102190477 AOX1 AOX1 MYC MYC IL13RA2 IL13RA2 LOC102171556 LOC102171556 IFNGR1 IFNGR1 PTPN2 PTPN2 PIAS1 PIAS1 IL17D IL17D LIF LIF LIFR LIFR PIAS2 PIAS2 CTF1 CTF1 IL27RA IL27RA CSF3 CSF3 AKT2 AKT2 CISH CISH PIAS4 PIAS4 PIK3R3 PIK3R3 IRF9 IRF9 LOC102178616 LOC102178616 GRB2 GRB2 STAT2 STAT2 PIK3CA PIK3CA IL20RA IL20RA BCL2 BCL2 LOC108638107 LOC108638107 IFNG IFNG IL10 IL10 IL12B IL12B IL11 IL11 IFNGR2 IFNGR2 CREBBP CREBBP THPO THPO LOC102190507 LOC102190507 EP300 EP300 IFNAR1 IFNAR1 IL22 IL22 LOC102182821 LOC102182821 IL20RB IL20RB TYK2 TYK2 LOC108638229 LOC108638229 SOS1 SOS1 GHR GHR LOC108633160 LOC108633160 IL4 IL4 LOC108635455 LOC108635455 LOC108635454 LOC108635454 PTPN11 PTPN11 LOC108635503 LOC108635503 LEP LEP PIK3CB PIK3CB OSM OSM IL10RB IL10RB IFNAR2 IFNAR2 PTPN6 PTPN6 MTOR MTOR IL13 IL13 LOC108634976 LOC108634976 PIK3CD PIK3CD STAT3 STAT3 IL4R IL4R LOC102188176 LOC102188176 STAM2 STAM2 EGFR EGFR LOC102180492 LOC102180492 IL7R IL7R STAT4 STAT4 IL24 IL24 PIK3R1 PIK3R1 PRP1 PRP1 STAT5B STAT5B STAT5A STAT5A LOC102180550 LOC102180550 IL21 IL21 AKT1 AKT1 LOC102171116 LOC102171116 LEPR LEPR IL23R IL23R IL21R IL21R IFNLR1 IFNLR1 BCL2L1 BCL2L1 LOC102179668 LOC102179668 IL15 IL15 IL2 IL2 PDGFRB PDGFRB MPL MPL CCND2 CCND2 AKT3 AKT3 EPO EPO SOS2 SOS2 STAT6 STAT6 PDGFB PDGFB IL22RA1 IL22RA1 ENSCHIP00000032473 ENSCHIP00000032473 IL22RA2 IL22RA2 IL12RB2 IL12RB2 CCND3 CCND3 MCL1 MCL1 SOCS2 SOCS2 IL12RB1 IL12RB1 CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRLF2Cytokine receptor like factor 2. (378 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (425 aa)
LOC108634973Uncharacterized protein. (195 aa)
LOC108636617Uncharacterized protein. (195 aa)
SOCS1Suppressor of cytokine signaling 1. (219 aa)
LOC108635529Uncharacterized protein. (189 aa)
LOC108636634Uncharacterized protein. (186 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
LOC102180392Uncharacterized protein. (195 aa)
LOC108633243Uncharacterized protein. (186 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAMSignal transducing adaptor molecule. (534 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC108636616Uncharacterized protein. (195 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
LOC102179943Uncharacterized protein. (189 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
IL2RGFibronectin type-III domain-containing protein. (378 aa)
CSF3RColony stimulating factor 3 receptor. (840 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
IFNEInterferon epsilon. (193 aa)
LOC108636544Uncharacterized protein. (186 aa)
LOC108634604Uncharacterized protein. (195 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
LOC108636623Uncharacterized protein. (195 aa)
IFNAUncharacterized protein. (189 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
OSMROncostatin M receptor. (948 aa)
LOC102174842Uncharacterized protein. (189 aa)
LOC108636618Uncharacterized protein. (195 aa)
IL2RAInterleukin 2 receptor subunit alpha. (285 aa)
LOC108636628Uncharacterized protein. (195 aa)
IL11RAUncharacterized protein. (439 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
LOC108635000Uncharacterized protein. (195 aa)
LOC108636627Uncharacterized protein. (189 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
LOC108636629Uncharacterized protein. (186 aa)
LOC108636626Uncharacterized protein. (195 aa)
LOC102181867Uncharacterized protein. (186 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CNTFCiliary neurotrophic factor. (199 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (581 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
PRP6Prolactin-related protein-6. (239 aa)
LOC102180761Uncharacterized protein. (189 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
IL5RAInterleukin 5 receptor subunit alpha. (395 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (890 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC108636632Uncharacterized protein. (186 aa)
IL20Interleukin 20. (175 aa)
LOC102170569Uncharacterized protein. (211 aa)
IL15RASushi domain-containing protein. (277 aa)
LOC108636620Uncharacterized protein. (195 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC102184390Uncharacterized protein. (287 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
LOC102181595Uncharacterized protein. (186 aa)
IL7Interleukin 7. (181 aa)
LOC102190477Uncharacterized protein. (238 aa)
AOX1Aldehyde oxidase 1. (1339 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (380 aa)
LOC102171556Uncharacterized protein. (1318 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (417 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
IL17DInterleukin 17D. (193 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
LIFRLIF receptor subunit alpha. (1066 aa)
PIAS2Uncharacterized protein. (621 aa)
CTF1Cardiotrophin 1. (202 aa)
IL27RAInterleukin 27 receptor subunit alpha. (655 aa)
CSF3Colony stimulating factor 3. (226 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
CISHCytokine inducible SH2 containing protein. (254 aa)
PIAS4Protein inhibitor of activated STAT 4. (513 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRF9Interferon regulatory factor 9. (470 aa)
LOC102178616Uncharacterized protein. (265 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL20RAInterleukin 20 receptor subunit alpha. (558 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
LOC108638107Uncharacterized protein. (238 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IL10Interleukin 10. (177 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
IL11Interleukin 11. (191 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
CREBBPCREB binding protein. (2435 aa)
THPOThrombopoietin. (353 aa)
LOC102190507Uncharacterized protein. (139 aa)
EP300E1A binding protein p300. (2411 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
IL22Interleukin 22. (190 aa)
LOC102182821Uncharacterized protein. (207 aa)
IL20RBInterleukin 20 receptor subunit beta. (305 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
LOC108638229Uncharacterized protein. (217 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
GHRFibronectin type-III domain-containing protein. (641 aa)
LOC108633160Uncharacterized protein. (189 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
LOC108635455Uncharacterized protein. (195 aa)
LOC108635454Uncharacterized protein. (195 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LOC108635503Uncharacterized protein. (195 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
OSMOncostatin M. (239 aa)
IL10RBInterleukin 10 receptor subunit beta. (317 aa)
IFNAR2Uncharacterized protein. (534 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IL13Interleukin 13. (131 aa)
LOC108634976Uncharacterized protein. (181 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL4RInterleukin 4 receptor. (805 aa)
LOC102188176FAD-binding PCMH-type domain-containing protein. (1339 aa)
STAM2Signal transducing adaptor molecule 2. (526 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
LOC102180492Uncharacterized protein. (186 aa)
IL7RInterleukin 7 receptor. (459 aa)
STAT4Signal transducer and activator of transcription. (797 aa)
IL24Interleukin 24. (196 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRP1Prolactin-related protein-1. (238 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
LOC102180550Uncharacterized protein. (237 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
LOC102171116Uncharacterized protein. (226 aa)
LEPRLeptin receptor. (1166 aa)
IL23RInterleukin 23 receptor. (642 aa)
IL21RInterleukin 21 receptor. (531 aa)
IFNLR1Interferon lambda receptor 1. (523 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
LOC102179668Uncharacterized protein. (191 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (643 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EPOErythropoietin. (208 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (581 aa)
ENSCHIP00000032473Uncharacterized protein. (189 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (230 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (877 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (730 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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