STRINGSTRING
MAPK1 MAPK1 MAPK14 MAPK14 LOC100861170 LOC100861170 TAB3 TAB3 FOSB FOSB JUN JUN TRAF2 TRAF2 FADD FADD IL17F IL17F NFKB1 NFKB1 ANAPC5 ANAPC5 HSP90B1 HSP90B1 NFKBIA NFKBIA MMP1 MMP1 SRSF1 SRSF1 CCL17 CCL17 MAP3K7 MAP3K7 IKBKE IKBKE IL6 IL6 MAPK10 MAPK10 CCL11 CCL11 MAPK4 MAPK4 LOC102191570 LOC102191570 CASP3 CASP3 MAPK7 MAPK7 MAPK9 MAPK9 IL17D IL17D LOC102182395 LOC102182395 IKBKB IKBKB ELAVL1 ELAVL1 GSK3B GSK3B IL17RA IL17RA CSF3 CSF3 RELA RELA CXCL10 CXCL10 CCL20 CCL20 USP25 USP25 TRAF6 TRAF6 MAPK3 MAPK3 IFNG IFNG TRAF5 TRAF5 S100A9 S100A9 IL25 IL25 MMP9 MMP9 CHUK CHUK HSP90AB1 HSP90AB1 CASP8 CASP8 IL4 IL4 TRAF3IP2 TRAF3IP2 IL13 IL13 CXCL8 CXCL8 TAB2 TAB2 LCN2 LCN2 TNFAIP3 TNFAIP3 S100A7A S100A7A IL17A IL17A HSP90AA1 HSP90AA1 MMP3 MMP3 TBK1 TBK1 FOSL1 FOSL1 PTGS2 PTGS2 IKBKG IKBKG CCL2 CCL2 MAPK13 MAPK13 IL17C IL17C LOC102182683 LOC102182683 IL17RB IL17RB IL1B IL1B TRADD TRADD FOS FOS MAPK8 MAPK8 LOC108633164 LOC108633164 MAPK6 MAPK6 TRAF3 TRAF3 S100A8 S100A8 IL17B IL17B CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
LOC100861170Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
TRAF2TNF receptor-associated factor. (497 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
IL17FUncharacterized protein. (178 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ANAPC5Anaphase promoting complex subunit 5. (747 aa)
HSP90B1Heat shock protein 90 beta family member 1. (836 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MMP1Matrix metallopeptidase 1. (475 aa)
SRSF1Uncharacterized protein. (248 aa)
CCL17C-C motif chemokine. (102 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (712 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
CCL11C-C motif chemokine. (97 aa)
MAPK4Mitogen-activated protein kinase 4. (588 aa)
LOC102191570Protein S100; Belongs to the S-100 family. (101 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (780 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IL17DInterleukin 17D. (193 aa)
LOC102182395C-X-C motif chemokine. (103 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
IL17RAInterleukin 17 receptor A. (786 aa)
CSF3Colony stimulating factor 3. (226 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
CXCL10C-X-C motif chemokine. (102 aa)
CCL20C-C motif chemokine. (96 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (151 aa)
IL25Interleukin 25. (183 aa)
MMP9Uncharacterized protein. (709 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
IL13Interleukin 13. (131 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
TNFAIP3TNF alpha induced protein 3. (785 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
IL17AInterleukin-17A. (153 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
TBK1TANK binding kinase 1. (734 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
CCL2C-C motif chemokine. (98 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL17CInterleukin 17C. (178 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
IL17RBInterleukin 17 receptor B. (497 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
LOC108633164Protein S100; Belongs to the S-100 family. (101 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (89 aa)
IL17BInterleukin 17B. (176 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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