STRINGSTRING
PPP3CB PPP3CB MAPK1 MAPK1 CD40LG CD40LG MAPK14 MAPK14 PAK1 PAK1 JUN JUN PPP3R1 PPP3R1 HRAS HRAS CD3D CD3D RAF1 RAF1 CD247 CD247 CTLA4 CTLA4 NFKB1 NFKB1 FYN FYN PDCD1 PDCD1 NFKBIA NFKBIA DLG1 DLG1 NCK2 NCK2 CD4 CD4 VAV1 VAV1 BCL10 BCL10 MAP3K7 MAP3K7 ZAP70 ZAP70 MAPK10 MAPK10 NCK1 NCK1 LCK LCK RHOA RHOA CDC42 CDC42 MAPK9 MAPK9 IKBKB IKBKB GSK3B GSK3B PPP3CC PPP3CC MAP2K2 MAP2K2 RELA RELA AKT2 AKT2 PAK4 PAK4 GRAP2 GRAP2 PDPK1 PDPK1 PIK3R3 PIK3R3 PRKCQ PRKCQ GRB2 GRB2 VAV3 VAV3 MAPK3 MAPK3 PIK3CA PIK3CA IFNG IFNG MALT1 MALT1 IL10 IL10 CHUK CHUK MAP3K14 MAP3K14 MAP3K8 MAP3K8 PAK2 PAK2 SOS1 SOS1 IL4 IL4 PIK3CB PIK3CB PTPN6 PTPN6 PIK3CD PIK3CD CD8B CD8B PAK5 PAK5 CDK4 CDK4 NFATC1 NFATC1 CARD11 CARD11 PIK3R1 PIK3R1 MAP2K7 MAP2K7 VAV2 VAV2 TEC TEC NFATC3 NFATC3 PAK3 PAK3 NFKBIB NFKBIB NRAS NRAS AKT1 AKT1 IKBKG IKBKG MAPK13 MAPK13 PAK6 PAK6 CBLB CBLB CD28 CD28 IL2 IL2 PLCG1 PLCG1 ICOS ICOS AKT3 AKT3 FOS FOS MAPK8 MAPK8 SOS2 SOS2 KRAS KRAS PPP3CA PPP3CA CD8A CD8A ITK ITK CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CBSerine/threonine-protein phosphatase. (535 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PPP3R1Uncharacterized protein. (170 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CD3DCD3d molecule. (167 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CD247CD247 molecule. (166 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FYNTyrosine-protein kinase. (537 aa)
PDCD1Ig-like domain-containing protein. (280 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
NCK2Cytoplasmic protein. (376 aa)
CD4CD4 molecule. (455 aa)
VAV1Vav guanine nucleotide exchange factor 1. (844 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ZAP70Tyrosine-protein kinase. (622 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
NCK1Cytoplasmic protein. (377 aa)
LCKTyrosine-protein kinase. (509 aa)
RHOARas-like protein family member A. (193 aa)
CDC42Uncharacterized protein. (191 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PAK4Non-specific serine/threonine protein kinase. (584 aa)
GRAP2GRB2 related adaptor protein 2. (318 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R3Uncharacterized protein. (461 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (711 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
MALT1MALT1 paracaspase. (830 aa)
IL10Interleukin 10. (177 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CD8BIg-like domain-containing protein. (207 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (558 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
TECTyrosine-protein kinase. (632 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
NFKBIBNFKB inhibitor beta. (364 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CBLBCbl proto-oncogene B. (983 aa)
CD28CD28 molecule. (228 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
ICOSInducible T cell costimulator. (209 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
CD8ACD8a molecule. (233 aa)
ITKTyrosine-protein kinase. (619 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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