STRINGSTRING
CD99L2 CD99L2 VCL VCL MAPK14 MAPK14 OCLN OCLN CLDN9 CLDN9 CLDN6 CLDN6 MYLPF MYLPF CLDN3 CLDN3 CLDN20 CLDN20 CLDN4 CLDN4 LOC102186369 LOC102186369 CTNNA1 CTNNA1 RHOH RHOH CLDN34 CLDN34 SIPA1 SIPA1 LOC102186657 LOC102186657 CLDN17 CLDN17 MYL12B MYL12B LOC102175177 LOC102175177 GNAI2 GNAI2 RAPGEF3 RAPGEF3 PXN PXN CLDN14 CLDN14 ARHGAP5 ARHGAP5 ITGB1 ITGB1 CXCL12 CXCL12 CLDN11 CLDN11 ACTN4 ACTN4 VAV1 VAV1 CLDN2 CLDN2 VASP VASP ITGAL ITGAL CYBB CYBB NCF4 NCF4 MSN MSN ROCK2 ROCK2 TXK TXK ACTB ACTB CXCR4 CXCR4 RHOA RHOA CDC42 CDC42 PTK2 PTK2 ITGB2 ITGB2 ITGAM ITGAM CYBA CYBA RAPGEF4 RAPGEF4 CLDN10 CLDN10 JAM2 JAM2 CDH5 CDH5 CD99 CD99 PIK3R3 PIK3R3 ACTN1 ACTN1 ICAM1 ICAM1 CTNNA3 CTNNA3 VAV3 VAV3 PIK3CA PIK3CA ROCK1 ROCK1 MMP2 MMP2 MYL12A MYL12A MMP9 MMP9 PRKCB PRKCB PLCG2 PLCG2 RAP1A RAP1A CLDN19 CLDN19 EZR EZR PECAM1 PECAM1 PTPN11 PTPN11 ITGA4 ITGA4 PIK3CB PIK3CB CLDN5 CLDN5 PIK3CD PIK3CD RASSF5 RASSF5 CLDN16 CLDN16 MYL9 MYL9 PIK3R1 PIK3R1 F11R F11R CLDN1 CLDN1 LOC102174895 LOC102174895 VAV2 VAV2 MYL7 MYL7 NCF1 NCF1 AFDN AFDN GNAI1 GNAI1 MAPK13 MAPK13 PRKCG PRKCG THY1 THY1 PRKCA PRKCA CTNND1 CTNND1 ARHGAP35 ARHGAP35 CLDN18 CLDN18 GNAI3 GNAI3 PLCG1 PLCG1 RAC2 RAC2 CLDN7 CLDN7 CTNNB1 CTNNB1 PTK2B PTK2B BCAR1 BCAR1 ESAM ESAM RAP1B RAP1B CLDN15 CLDN15 CTNNA2 CTNNA2 CLDN8 CLDN8 ITK ITK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD99L2CD99 molecule like 2. (198 aa)
VCLVinculin. (1134 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
MYLPFUncharacterized protein. (169 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LOC102186369Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CTNNA1Catenin alpha 1. (1018 aa)
RHOHRas homolog family member H. (191 aa)
CLDN34Uncharacterized protein. (259 aa)
SIPA1Signal-induced proliferation-associated 1. (1038 aa)
LOC102186657Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
MYL12BMyosin light chain 12B. (171 aa)
LOC102175177Uncharacterized protein. (740 aa)
GNAI2G protein subunit alpha i2. (357 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (924 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (581 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
ACTN4Actinin alpha 4. (933 aa)
VAV1Vav guanine nucleotide exchange factor 1. (844 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1178 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
MSNMoesin. (666 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
TXKTyrosine-protein kinase. (527 aa)
ACTBUncharacterized protein. (375 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
RHOARas-like protein family member A. (193 aa)
CDC42Uncharacterized protein. (191 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (774 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (847 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
JAM2Junctional adhesion molecule 2. (279 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
CD99Uncharacterized protein. (238 aa)
PIK3R3Uncharacterized protein. (461 aa)
ACTN1Actinin alpha 1. (914 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CTNNA3Uncharacterized protein. (530 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MYL12AMyosin light chain 12A. (178 aa)
MMP9Uncharacterized protein. (709 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
EZREzrin. (581 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RASSF5Ras association domain family member 5. (420 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
MYL9Myosin light chain 9. (172 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
F11RF11 receptor. (298 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC102174895Uncharacterized protein. (735 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
MYL7Myosin light chain 7. (175 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
AFDNAfadin, adherens junction formation factor. (1837 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
THY1Thy-1 cell surface antigen. (161 aa)
PRKCAUncharacterized protein. (605 aa)
CTNND1Catenin delta 1. (939 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
RAC2Rac family small GTPase 2. (192 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CTNNB1Catenin beta 1. (781 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (848 aa)
ESAMEndothelial cell adhesion molecule. (396 aa)
RAP1BRas-related protein Rap-1B. (184 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
CTNNA2Uncharacterized protein. (394 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
ITKTyrosine-protein kinase. (619 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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