STRINGSTRING
MAPK1 MAPK1 HRAS HRAS KCNN2 KCNN2 TRPC4 TRPC4 RAF1 RAF1 PLCB2 PLCB2 CACNA1G CACNA1G ITPR3 ITPR3 KCNJ11 KCNJ11 GNAQ GNAQ ESR2 ESR2 GNA11 GNA11 TRPC5 TRPC5 KCNJ5 KCNJ5 CACNA1S CACNA1S ARRB1 ARRB1 GABBR1 GABBR1 KCNN1 KCNN1 SPP1 SPP1 MAP2K2 MAP2K2 AKT2 AKT2 CACNA1C CACNA1C PIK3R3 PIK3R3 ARRB2 ARRB2 MAPK3 MAPK3 PIK3CA PIK3CA GNRH1 GNRH1 ITPR2 ITPR2 PRKCB PRKCB HCN3 HCN3 PLCB1 PLCB1 KCNN4 KCNN4 CGA CGA KCNN3 KCNN3 ITPR1 ITPR1 KCNJ3 KCNJ3 CACNA1D CACNA1D PLCB3 PLCB3 PIK3CB PIK3CB KCNJ9 KCNJ9 PIK3CD PIK3CD TRPC1 TRPC1 PIK3R1 PIK3R1 HCN2 HCN2 CACNA1I CACNA1I GPER1 GPER1 NRAS NRAS KCNJ6 KCNJ6 AKT1 AKT1 PLCB4 PLCB4 PRKCG PRKCG PRKCA PRKCA KISS1 KISS1 KISS1R KISS1R HCN1 HCN1 GABBR2 GABBR2 AKT3 AKT3 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (852 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (979 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2385 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2653 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (388 aa)
GNAQG protein subunit alpha q. (359 aa)
ESR2Uncharacterized protein. (527 aa)
GNA11G protein subunit alpha 11. (361 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5. (640 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1809 aa)
ARRB1Arrestin beta 1. (418 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (977 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (625 aa)
SPP1Uncharacterized protein. (279 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2092 aa)
PIK3R3Uncharacterized protein. (461 aa)
ARRB2Arrestin beta 2. (420 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (783 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (428 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (713 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2110 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (411 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (904 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2185 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (428 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
PRKCAUncharacterized protein. (605 aa)
KISS1KiSS-1 metastasis-suppressor. (135 aa)
KISS1RG_PROTEIN_RECEP_F1_2 domain-containing protein. (384 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (877 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (963 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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