STRINGSTRING
MAPK1 MAPK1 COL4A5 COL4A5 COL4A6 COL4A6 MAPK14 MAPK14 TGFB3 TGFB3 JAK2 JAK2 JUN JUN HRAS HRAS SELE SELE PLCB2 PLCB2 NFKB1 NFKB1 VEGFA VEGFA STAT1 STAT1 LOC102175177 LOC102175177 CCND1 CCND1 AGT AGT THBD THBD PRKCZ PRKCZ AGTR1 AGTR1 TGFBR2 TGFBR2 EDN1 EDN1 TGFB1 TGFB1 IL6 IL6 MAPK10 MAPK10 PLCD1 PLCD1 CYBB CYBB NOS3 NOS3 CASP3 CASP3 SMAD3 SMAD3 AGER AGER CDC42 CDC42 MAPK9 MAPK9 RELA RELA AKT2 AKT2 PRKCD PRKCD PIK3R3 PIK3R3 ICAM1 ICAM1 CDKN1B CDKN1B MAPK3 MAPK3 PIK3CA PIK3CA MMP2 MMP2 BCL2 BCL2 BAX BAX PRKCB PRKCB PLCG2 PLCG2 PLCB1 PLCB1 FOXO1 FOXO1 PRKCE PRKCE NOX1 NOX1 PLCB3 PLCB3 PIK3CB PIK3CB F3 F3 CXCL8 CXCL8 SMAD2 SMAD2 PIK3CD PIK3CD STAT3 STAT3 CDK4 CDK4 SERPINE1 SERPINE1 NFATC1 NFATC1 PLCE1 PLCE1 PIK3R1 PIK3R1 COL1A1 COL1A1 NOX4 NOX4 FN1 FN1 STAT5B STAT5B LOC102174895 LOC102174895 COL4A1 COL4A1 STAT5A STAT5A TGFBR1 TGFBR1 PLCD4 PLCD4 TGFB2 TGFB2 EGR1 EGR1 NRAS NRAS AKT1 AKT1 CCL2 CCL2 MAPK13 MAPK13 PLCB4 PLCB4 VEGFD VEGFD VEGFC VEGFC PRKCA PRKCA IL1B IL1B PLCG1 PLCG1 PLCD3 PLCD3 AKT3 AKT3 DIAPH1 DIAPH1 MAPK8 MAPK8 COL4A4 COL4A4 COL1A2 COL1A2 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
COL4A5Collagen IV NC1 domain-containing protein. (568 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SELESelectin E. (487 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
LOC102175177Uncharacterized protein. (740 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
THBDThrombomodulin. (578 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
EDN1Endothelin 1. (202 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
PLCD1Phosphoinositide phospholipase C. (765 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
CDC42Uncharacterized protein. (191 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
PIK3R3Uncharacterized protein. (461 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
FOXO1Forkhead box O1. (668 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
NOX1NADPH oxidase 1. (498 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
PLCE1Phosphoinositide phospholipase C. (1931 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
NOX4NADPH oxidase 4. (578 aa)
FN1Fibronectin 1. (2478 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
LOC102174895Uncharacterized protein. (735 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
PLCD4Phosphoinositide phospholipase C. (793 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
CCL2C-C motif chemokine. (98 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
PRKCAUncharacterized protein. (605 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
PLCD3Phosphoinositide phospholipase C. (782 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
DIAPH1Diaphanous related formin 1. (1258 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
COL4A4Collagen type IV alpha 4 chain. (1434 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.