STRINGSTRING
MAPK1 MAPK1 MAPK14 MAPK14 TGFB3 TGFB3 JAK2 JAK2 JUN JUN ENSCHIP00000003677 ENSCHIP00000003677 LOC102185698 LOC102185698 C3 C3 NFKB1 NFKB1 HLA-DMA HLA-DMA LOC102186442 LOC102186442 STAT1 STAT1 ELK1 ELK1 EEF1A1 EEF1A1 NFKBIA NFKBIA HLA-DOB HLA-DOB ITGB1 ITGB1 MAP3K7 MAP3K7 TGFB1 TGFB1 IRAK1 IRAK1 CYBB CYBB NCF4 NCF4 JAK1 JAK1 LOC106503481 LOC106503481 HLA-DRA HLA-DRA LOC102179937 LOC102179937 IFNGR1 IFNGR1 ITGB2 ITGB2 ITGAM ITGAM HLA-DOA HLA-DOA CYBA CYBA TAB1 TAB1 RELA RELA TRAF6 TRAF6 MAPK3 MAPK3 LOC102180664 LOC102180664 IFNG IFNG EEF1A2 EEF1A2 ENSCHIP00000016659 ENSCHIP00000016659 IL10 IL10 PRKCB PRKCB IL12B IL12B MYD88 MYD88 IFNGR2 IFNGR2 IRAK4 IRAK4 ENSCHIP00000019274 ENSCHIP00000019274 TLR4 TLR4 IL4 IL4 ITGA4 ITGA4 PTPN6 PTPN6 TAB2 TAB2 LOC102186727 LOC102186727 NCF1 NCF1 MARCKSL1 MARCKSL1 TGFB2 TGFB2 NFKBIB NFKBIB NOS2 NOS2 PTGS2 PTGS2 MAPK13 MAPK13 IL1B IL1B FOS FOS TLR2 TLR2 LOC102187998 LOC102187998 LOC102173987 LOC102173987
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
ENSCHIP00000003677Tr-type G domain-containing protein. (438 aa)
LOC102185698Uncharacterized protein. (250 aa)
C3Complement C3. (1663 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (278 aa)
LOC102186442Ig-like domain-containing protein. (290 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
ELK1ETS transcription factor ELK1. (440 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (270 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (718 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC106503481Ig-like domain-containing protein. (274 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
LOC102179937Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (774 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (332 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC102180664Ig-like domain-containing protein. (266 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
ENSCHIP00000016659Tr-type G domain-containing protein. (120 aa)
IL10Interleukin 10. (177 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
ENSCHIP00000019274Ig-like domain-containing protein. (253 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LOC102186727Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
MARCKSL1MARCKS like 1. (198 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NFKBIBNFKB inhibitor beta. (364 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1154 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
LOC102173987Uncharacterized protein. (349 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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