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MAPK1 MAPK1 MAPK14 MAPK14 TGFB3 TGFB3 LOC108636634 LOC108636634 LOC108633243 LOC108633243 LOC108638246 LOC108638246 JUN JUN LOC108633189 LOC108633189 GNA15 GNA15 CD3D CD3D CD247 CD247 PLCB2 PLCB2 PPP2R2A PPP2R2A FADD FADD PPP2CB PPP2CB LOC108636544 LOC108636544 C3 C3 NFKB1 NFKB1 GNAI2 GNAI2 LOC108636629 LOC108636629 NFKBIA NFKBIA LOC102181867 LOC102181867 C1QC C1QC KNG1 KNG1 GNAQ GNAQ TGFBR2 TGFBR2 LOC102188874 LOC102188874 TGFB1 TGFB1 GNA11 GNA11 ACE ACE IRAK1 IRAK1 IL6 IL6 LOC108636632 LOC108636632 MAPK10 MAPK10 TNFRSF1A TNFRSF1A LOC102181595 LOC102181595 IFNGR1 IFNGR1 MAPK9 MAPK9 IKBKB IKBKB LOC102179590 LOC102179590 PPP2R2B PPP2R2B RELA RELA AKT2 AKT2 PIK3R3 PIK3R3 TRAF6 TRAF6 MAPK3 MAPK3 PIK3CA PIK3CA PPP2R2C PPP2R2C CFLAR CFLAR IFNG IFNG CCL5 CCL5 IL10 IL10 IL12B IL12B LOC102181154 LOC102181154 CHUK CHUK C1QB C1QB MYD88 MYD88 IFNGR2 IFNGR2 GNAO1 GNAO1 IRAK4 IRAK4 PLCB1 PLCB1 TLR4 TLR4 CASP8 CASP8 PLCB3 PLCB3 BDKRB2 BDKRB2 PIK3CB PIK3CB PPP2R1B PPP2R1B CXCL8 CXCL8 SMAD2 SMAD2 PIK3CD PIK3CD SERPINE1 SERPINE1 GNA14 GNA14 PIK3R1 PIK3R1 TICAM1 TICAM1 LOC102170772 LOC102170772 GNAL GNAL TGFBR1 TGFBR1 TGFB2 TGFB2 FASLG FASLG NOS2 NOS2 AKT1 AKT1 GNAI1 GNAI1 CALR CALR PPP2R1A PPP2R1A IKBKG IKBKG CCL2 CCL2 MAPK13 MAPK13 PLCB4 PLCB4 PPP2CA PPP2CA TLR9 TLR9 LOC106503207 LOC106503207 IL1B IL1B GNAI3 GNAI3 ADCY1 ADCY1 IL2 IL2 C1QA C1QA AKT3 AKT3 FOS FOS MAPK8 MAPK8 MAP2K4 MAP2K4 TLR2 TLR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
LOC108636634Uncharacterized protein. (186 aa)
LOC108633243Uncharacterized protein. (186 aa)
LOC108638246C-C motif chemokine. (93 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LOC108633189Uncharacterized protein. (241 aa)
GNA15G protein subunit alpha 15. (374 aa)
CD3DCD3d molecule. (167 aa)
CD247CD247 molecule. (166 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC108636544Uncharacterized protein. (186 aa)
C3Complement C3. (1663 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
GNAI2G protein subunit alpha i2. (357 aa)
LOC108636629Uncharacterized protein. (186 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LOC102181867Uncharacterized protein. (186 aa)
C1QCComplement C1q C chain. (244 aa)
KNG1Kininogen 1. (619 aa)
GNAQG protein subunit alpha q. (359 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
LOC102188874Uncharacterized protein. (394 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GNA11G protein subunit alpha 11. (361 aa)
ACEAngiotensin-converting enzyme. (1313 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (718 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC108636632Uncharacterized protein. (186 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
LOC102181595Uncharacterized protein. (186 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LOC102179590C-C motif chemokine. (89 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PIK3R3Uncharacterized protein. (461 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (484 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CCL5C-C motif chemokine. (91 aa)
IL10Interleukin 10. (177 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
LOC102181154C-C motif chemokine. (93 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
C1QBComplement C1q B chain. (247 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
GNAO1G protein subunit alpha o1. (354 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (615 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
GNA14G protein subunit alpha 14. (355 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (786 aa)
LOC102170772C-C motif chemokine. (105 aa)
GNALG protein subunit alpha L. (389 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1154 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CALRCalreticulin. (417 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (598 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
CCL2C-C motif chemokine. (98 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
TLR9TIR domain-containing protein. (1070 aa)
LOC106503207Angiotensin-converting enzyme. (722 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
C1QAComplement C1q A chain. (313 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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