STRINGSTRING
MAPK1 MAPK1 NXT2 NXT2 LOC108635529 LOC108635529 MX1 MX1 LOC108636634 LOC108636634 LOC108633243 LOC108633243 JAK2 JAK2 LOC102179943 LOC102179943 RAF1 RAF1 SLC25A5 SLC25A5 FADD FADD LOC108636544 LOC108636544 NFKB1 NFKB1 PML PML IFNA IFNA LOC102174842 LOC102174842 HLA-DMA HLA-DMA LOC102186442 LOC102186442 STAT1 STAT1 LOC108636627 LOC108636627 LOC108636629 LOC108636629 NFKBIA NFKBIA LOC102181867 LOC102181867 HLA-DOB HLA-DOB LOC102180761 LOC102180761 EIF2S1 EIF2S1 PLG PLG SOCS3 SOCS3 IRF7 IRF7 LOC102172689 LOC102172689 CDK6 CDK6 CASP9 CASP9 IKBKE IKBKE SLC25A6 SLC25A6 PABPN1 PABPN1 RAB11A RAB11A IL6 IL6 LOC108636632 LOC108636632 TRIM25 TRIM25 TMPRSS4 TMPRSS4 JAK1 JAK1 TNFRSF1A TNFRSF1A LOC106503481 LOC106503481 LOC102181595 LOC102181595 HLA-DRA HLA-DRA LOC102179937 LOC102179937 ACTB ACTB CASP3 CASP3 IFNGR1 IFNGR1 MX2 MX2 ENSCHIP00000012455 ENSCHIP00000012455 IKBKB IKBKB HLA-DOA HLA-DOA BID BID LOC102178719 LOC102178719 MAP2K2 MAP2K2 RELA RELA AKT2 AKT2 HNRNPUL1 HNRNPUL1 LOC108634246 LOC108634246 CXCL10 CXCL10 MAVS MAVS PIK3R3 PIK3R3 TLR3 TLR3 IRF9 IRF9 ICAM1 ICAM1 STAT2 STAT2 MAPK3 MAPK3 PIK3CA PIK3CA TMPRSS11D TMPRSS11D LOC102180664 LOC102180664 BAK1 BAK1 EIF2AK2 EIF2AK2 ENSCHIP00000015988 ENSCHIP00000015988 BAX BAX NUP98 NUP98 IFNG IFNG CCL5 CCL5 TNFSF10 TNFSF10 PRKCB PRKCB IL12B IL12B CHUK CHUK ADAR ADAR MYD88 MYD88 IFNGR2 IFNGR2 CREBBP CREBBP NLRX1 NLRX1 EP300 EP300 SLC25A31 SLC25A31 IRF3 IRF3 IRAK4 IRAK4 IFNAR1 IFNAR1 XPO1 XPO1 ENSCHIP00000019274 ENSCHIP00000019274 TLR4 TLR4 TYK2 TYK2 LOC108633160 LOC108633160 CASP8 CASP8 LOC102183400 LOC102183400 CIITA CIITA PIK3CB PIK3CB IFIH1 IFIH1 IFNAR2 IFNAR2 OAS1 OAS1 CXCL8 CXCL8 FDPS FDPS PIK3CD PIK3CD IL33 IL33 PRSS2 PRSS2 CDK4 CDK4 IL18 IL18 TLR7 TLR7 PIK3R1 PIK3R1 TICAM1 TICAM1 RAE1 RAE1 LOC102175959 LOC102175959 RNASEL RNASEL RSAD2 RSAD2 LOC102186727 LOC102186727 ENSCHIP00000025610 ENSCHIP00000025610 RAB11B RAB11B FASLG FASLG TBK1 TBK1 NFKBIB NFKBIB PYCARD PYCARD NLRP3 NLRP3 AKT1 AKT1 DNAJC3 DNAJC3 DNAJB1 DNAJB1 IKBKG IKBKG CCL2 CCL2 LOC102186893 LOC102186893 VDAC1 VDAC1 PRKCA PRKCA IL1B IL1B TMPRSS2 TMPRSS2 TRADD TRADD LOC102177855 LOC102177855 AKT3 AKT3 CALCOCO2 CALCOCO2 KPNA5 KPNA5 LOC102173997 LOC102173997 DDX58 DDX58 APAF1 APAF1 LOC106501717 LOC106501717 KPNA7 KPNA7 ENSCHIP00000032473 ENSCHIP00000032473 TRAF3 TRAF3 KPNA1 KPNA1 LOC102187998 LOC102187998 SLC25A4 SLC25A4 CCND3 CCND3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
NXT2Nuclear transport factor 2 like export factor 2. (197 aa)
LOC108635529Uncharacterized protein. (189 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
LOC108636634Uncharacterized protein. (186 aa)
LOC108633243Uncharacterized protein. (186 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC102179943Uncharacterized protein. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
LOC108636544Uncharacterized protein. (186 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PMLPromyelocytic leukemia. (868 aa)
IFNAUncharacterized protein. (189 aa)
LOC102174842Uncharacterized protein. (189 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (278 aa)
LOC102186442Ig-like domain-containing protein. (290 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
LOC108636627Uncharacterized protein. (189 aa)
LOC108636629Uncharacterized protein. (186 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LOC102181867Uncharacterized protein. (186 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (270 aa)
LOC102180761Uncharacterized protein. (189 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
IRF7Interferon regulatory factor 7. (480 aa)
LOC102172689Importin subunit alpha; Functions in nuclear protein import. (529 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (712 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PABPN1BCL2L2-PABPN1 readthrough. (306 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC108636632Uncharacterized protein. (186 aa)
TRIM25Tripartite motif containing 25. (633 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (445 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
LOC106503481Ig-like domain-containing protein. (274 aa)
LOC102181595Uncharacterized protein. (186 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
LOC102179937Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ACTBUncharacterized protein. (375 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (713 aa)
ENSCHIP00000012455TNFR-Cys domain-containing protein. (161 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (332 aa)
BIDUncharacterized protein. (244 aa)
LOC102178719Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
HNRNPUL1Heterogeneous nuclear ribonucleoprotein U like 1. (835 aa)
LOC108634246Uncharacterized protein. (215 aa)
CXCL10C-X-C motif chemokine. (102 aa)
MAVSMitochondrial antiviral signaling protein. (522 aa)
PIK3R3Uncharacterized protein. (461 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
IRF9Interferon regulatory factor 9. (470 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
LOC102180664Ig-like domain-containing protein. (266 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (543 aa)
ENSCHIP00000015988Uncharacterized protein. (157 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NUP98Nucleoporin 98. (1816 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CCL5C-C motif chemokine. (91 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
ADARAdenosine deaminase RNA specific. (1175 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IFNGR2Interferon gamma receptor 2. (355 aa)
CREBBPCREB binding protein. (2435 aa)
NLRX1NLR family member X1. (973 aa)
EP300E1A binding protein p300. (2411 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
IRF3Interferon regulatory factor 3. (418 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
XPO1Exportin 1. (1071 aa)
ENSCHIP00000019274Ig-like domain-containing protein. (253 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
LOC108633160Uncharacterized protein. (189 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
LOC102183400Uncharacterized protein. (558 aa)
CIITAClass II major histocompatibility complex transactivator. (1129 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IFIH1Interferon induced with helicase C domain 1. (1023 aa)
IFNAR2Uncharacterized protein. (534 aa)
OAS12'-5'-oligoadenylate synthetase 1. (390 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (353 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IL33Interleukin 33. (274 aa)
PRSS2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TLR7TIR domain-containing protein. (1054 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (786 aa)
RAE1Ribonucleic acid export 1. (368 aa)
LOC102175959Uncharacterized protein. (292 aa)
RNASELRibonuclease L. (730 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (364 aa)
LOC102186727Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
ENSCHIP00000025610TNFR-Cys domain-containing protein. (164 aa)
RAB11BUncharacterized protein. (224 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
TBK1TANK binding kinase 1. (734 aa)
NFKBIBNFKB inhibitor beta. (364 aa)
PYCARDPYD and CARD domain containing. (196 aa)
NLRP3NLR family, pyrin domain containing 3. (1031 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
DNAJB1J domain-containing protein. (340 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
CCL2C-C motif chemokine. (98 aa)
LOC102186893Uncharacterized protein. (709 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
PRKCAUncharacterized protein. (605 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
LOC102177855Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (273 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (448 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
DDX58DExD/H-box helicase 58. (942 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (522 aa)
ENSCHIP00000032473Uncharacterized protein. (189 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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