STRINGSTRING
MAPK1 MAPK1 EREG EREG TGFB3 TGFB3 JUN JUN HRAS HRAS CDKN1A CDKN1A RAF1 RAF1 POLK POLK TCF7L2 TCF7L2 AXIN1 AXIN1 BBC3 BBC3 CCND1 CCND1 TCF7L1 TCF7L1 TGFBR2 TGFBR2 CASP9 CASP9 GADD45B GADD45B TGFB1 TGFB1 MLH1 MLH1 MAPK10 MAPK10 BIRC5 BIRC5 RALA RALA CASP3 CASP3 MYC MYC SMAD3 SMAD3 RHOA RHOA MAPK9 MAPK9 MSH6 MSH6 GSK3B GSK3B MAP2K2 MAP2K2 AKT2 AKT2 BAD BAD PIK3R3 PIK3R3 PMAIP1 PMAIP1 GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA BAK1 BAK1 BCL2 BCL2 BAX BAX GADD45G GADD45G APC2 APC2 TGFA TGFA SOS1 SOS1 RALB RALB PIK3CB PIK3CB MTOR MTOR SMAD2 SMAD2 BCL2L11 BCL2L11 PIK3CD PIK3CD AXIN2 AXIN2 EGFR EGFR PIK3R1 PIK3R1 RAC3 RAC3 DDB2 DDB2 MSH2 MSH2 TGFBR1 TGFBR1 TGFB2 TGFB2 ARAF ARAF NRAS NRAS AKT1 AKT1 APC APC RAC2 RAC2 TP53 TP53 DCC DCC AKT3 AKT3 FOS FOS GADD45A GADD45A CTNNB1 CTNNB1 MAPK8 MAPK8 SOS2 SOS2 LOC102173997 LOC102173997 LOC106501717 LOC106501717 KRAS KRAS MSH3 MSH3 TCF7 TCF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
EREGEpiregulin. (163 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
POLKDNA polymerase kappa. (905 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
AXIN1Axin 1. (867 aa)
BBC3Uncharacterized protein. (193 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MLH1MutL homolog 1. (758 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
BIRC5Uncharacterized protein. (142 aa)
RALARAS like proto-oncogene A. (206 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RHOARas-like protein family member A. (193 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
BADBCL2 associated agonist of cell death. (198 aa)
PIK3R3Uncharacterized protein. (461 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
APC2APC regulator of WNT signaling pathway 2. (2305 aa)
TGFATransforming growth factor alpha. (215 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
RALBRAS like proto-oncogene B. (206 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AXIN2Axin 2. (844 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (192 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
APCAPC regulator of WNT signaling pathway. (2880 aa)
RAC2Rac family small GTPase 2. (192 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
DCCDCC netrin 1 receptor. (1394 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CTNNB1Catenin beta 1. (781 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
TCF7Transcription factor 7. (418 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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