STRINGSTRING
MAPK1 MAPK1 TGFB3 TGFB3 PAK1 PAK1 FH FH JUN JUN HRAS HRAS CDKN1A CDKN1A CRKL CRKL LOC102188771 LOC102188771 RAF1 RAF1 CRK CRK VEGFA VEGFA HGF HGF TGFB1 TGFB1 ARNT ARNT CUL2 CUL2 CDC42 CDC42 MAP2K2 MAP2K2 AKT2 AKT2 ELOC ELOC ELOB ELOB PAK4 PAK4 BAD BAD SLC2A1 SLC2A1 HIF1A HIF1A PIK3R3 PIK3R3 ETS1 ETS1 GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA EPAS1 EPAS1 EGLN3 EGLN3 CREBBP CREBBP RAP1A RAP1A EP300 EP300 TGFA TGFA PAK2 PAK2 SOS1 SOS1 PTPN11 PTPN11 PIK3CB PIK3CB PIK3CD PIK3CD PAK5 PAK5 PIK3R1 PIK3R1 ARNT2 ARNT2 TGFB2 TGFB2 ARAF ARAF PAK3 PAK3 NRAS NRAS AKT1 AKT1 PAK6 PAK6 VHL VHL PRCC PRCC GAB1 GAB1 MET MET TFE3 TFE3 AKT3 AKT3 SOS2 SOS2 PDGFB PDGFB RBX1 RBX1 EGLN2 EGLN2 RAP1B RAP1B KRAS KRAS FLCN FLCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
FHFumarate hydratase. (514 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
LOC102188771Zf-rbx1 domain-containing protein. (108 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (768 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (745 aa)
CDC42Uncharacterized protein. (191 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
PAK4Non-specific serine/threonine protein kinase. (584 aa)
BADBCL2 associated agonist of cell death. (198 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
HIF1AUncharacterized protein. (823 aa)
PIK3R3Uncharacterized protein. (461 aa)
ETS1Uncharacterized protein. (485 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EPAS1Endothelial PAS domain protein 1. (898 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
CREBBPCREB binding protein. (2435 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
EP300E1A binding protein p300. (2411 aa)
TGFATransforming growth factor alpha. (215 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
VHLUncharacterized protein. (181 aa)
PRCCProline rich mitotic checkpoint control factor. (492 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (573 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RBX1RING-type domain-containing protein. (108 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (399 aa)
RAP1BRas-related protein Rap-1B. (184 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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