STRINGSTRING
MAPK1 MAPK1 RB1 RB1 HRAS HRAS CALML4 CALML4 PDGFRA PDGFRA CDKN1A CDKN1A PTEN PTEN RAF1 RAF1 E2F2 E2F2 POLK POLK CAMK2D CAMK2D CALML5 CALML5 CAMK2G CAMK2G CCND1 CCND1 E2F3 E2F3 SHC3 SHC3 CDK6 CDK6 GADD45B GADD45B CAMK4 CAMK4 SHC1 SHC1 SHC4 SHC4 MAP2K2 MAP2K2 AKT2 AKT2 E2F1 E2F1 PIK3R3 PIK3R3 GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA BAK1 BAK1 BAX BAX GADD45G GADD45G PRKCB PRKCB PLCG2 PLCG2 TGFA TGFA CAMK1 CAMK1 SOS1 SOS1 IGF1 IGF1 PIK3CB PIK3CB MDM2 MDM2 MTOR MTOR PIK3CD PIK3CD CDK4 CDK4 EGFR EGFR PIK3R1 PIK3R1 CALM1 CALM1 DDB2 DDB2 ARAF ARAF NRAS NRAS AKT1 AKT1 PRKCG PRKCG IGF1R IGF1R PRKCA PRKCA PLCG1 PLCG1 PDGFRB PDGFRB TP53 TP53 CAMK2A CAMK2A AKT3 AKT3 GADD45A GADD45A SOS2 SOS2 PDGFB PDGFB KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
RB1RB transcriptional corepressor 1. (931 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CALML4Calmodulin like 4. (153 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
E2F2E2F transcription factor 2. (437 aa)
POLKDNA polymerase kappa. (905 aa)
CAMK2DProtein kinase domain-containing protein. (532 aa)
CALML5Calmodulin like 5. (149 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (577 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
SHC3SHC adaptor protein 3. (592 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (464 aa)
SHC1SHC adaptor protein 1. (583 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
E2F1E2F transcription factor 1. (441 aa)
PIK3R3Uncharacterized protein. (461 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
TGFATransforming growth factor alpha. (215 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CALM1Calmodulin 2; Belongs to the calmodulin family. (149 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PRKCAUncharacterized protein. (605 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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