STRINGSTRING
PLAT PLAT MAPK1 MAPK1 PLAU PLAU RB1 RB1 HRAS HRAS PDGFRA PDGFRA CDKN1A CDKN1A PTEN PTEN RAF1 RAF1 E2F2 E2F2 NFKB1 NFKB1 CREB3L1 CREB3L1 TCF7L2 TCF7L2 HSP90B1 HSP90B1 NFKBIA NFKBIA NKX3-1 NKX3-1 CCND1 CCND1 E2F3 E2F3 TCF7L1 TCF7L1 INS INS CASP9 CASP9 ERG ERG LOC100861197 LOC100861197 IKBKB IKBKB GSK3B GSK3B ATF4 ATF4 MAP2K2 MAP2K2 RELA RELA ETV5 ETV5 AKT2 AKT2 PDPK1 PDPK1 BAD BAD E2F1 E2F1 PIK3R3 PIK3R3 PDGFC PDGFC CDKN1B CDKN1B CREB3L2 CREB3L2 GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA BCL2 BCL2 ZEB1 ZEB1 MMP9 MMP9 CHUK CHUK CREBBP CREBBP EP300 EP300 HSP90AB1 HSP90AB1 FGFR2 FGFR2 TGFA TGFA FOXO1 FOXO1 SOS1 SOS1 IGF1 IGF1 PIK3CB PIK3CB MDM2 MDM2 MTOR MTOR INSRR INSRR PIK3CD PIK3CD EGFR EGFR PIK3R1 PIK3R1 AR AR HSP90AA1 HSP90AA1 MMP3 MMP3 ARAF ARAF CCNE2 CCNE2 NRAS NRAS AKT1 AKT1 IKBKG IKBKG IGF1R IGF1R IL1R2 IL1R2 TMPRSS2 TMPRSS2 CCNE1 CCNE1 PDGFRB PDGFRB TP53 TP53 SPINT1 SPINT1 AKT3 AKT3 CTNNB1 CTNNB1 SOS2 SOS2 SRD5A2 SRD5A2 PDGFB PDGFB ERBB2 ERBB2 CREB3L3 CREB3L3 KRAS KRAS CREB1 CREB1 TCF7 TCF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
PLAUPlasminogen activator, urokinase. (440 aa)
RB1RB transcriptional corepressor 1. (931 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
E2F2E2F transcription factor 2. (437 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
HSP90B1Heat shock protein 90 beta family member 1. (836 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NKX3-1NK3 homeobox 1. (239 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
ERGETS transcription factor ERG. (486 aa)
LOC100861197Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (210 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ATF4Activating transcription factor 4. (352 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
ETV5Ets variant protein 5. (510 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
BADBCL2 associated agonist of cell death. (198 aa)
E2F1E2F transcription factor 1. (441 aa)
PIK3R3Uncharacterized protein. (461 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
MMP9Uncharacterized protein. (709 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
CREBBPCREB binding protein. (2435 aa)
EP300E1A binding protein p300. (2411 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
TGFATransforming growth factor alpha. (215 aa)
FOXO1Forkhead box O1. (668 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARAndrogen receptor. (891 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
IL1R2Interleukin 1 receptor type 2. (400 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (508 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CTNNB1Catenin beta 1. (781 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TCF7Transcription factor 7. (418 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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