STRINGSTRING
MAPK1 MAPK1 TGFB3 TGFB3 RB1 RB1 HRAS HRAS CDKN1A CDKN1A CRKL CRKL RAF1 RAF1 E2F2 E2F2 POLK POLK CBL CBL NFKB1 NFKB1 CRK CRK NFKBIA NFKBIA CCND1 CCND1 E2F3 E2F3 SHC3 SHC3 TGFBR2 TGFBR2 CDK6 CDK6 GADD45B GADD45B TGFB1 TGFB1 SHC1 SHC1 MYC MYC SMAD3 SMAD3 SHC4 SHC4 IKBKB IKBKB MAP2K2 MAP2K2 RELA RELA AKT2 AKT2 MECOM MECOM BAD BAD E2F1 E2F1 PIK3R3 PIK3R3 CDKN1B CDKN1B GRB2 GRB2 MAPK3 MAPK3 PIK3CA PIK3CA BAK1 BAK1 BAX BAX GADD45G GADD45G RUNX1 RUNX1 CHUK CHUK GAB2 GAB2 SOS1 SOS1 PTPN11 PTPN11 PIK3CB PIK3CB MDM2 MDM2 BCR BCR PIK3CD PIK3CD HDAC1 HDAC1 CDK4 CDK4 PIK3R1 PIK3R1 DDB2 DDB2 ABL1 ABL1 STAT5B STAT5B STAT5A STAT5A TGFBR1 TGFBR1 TGFB2 TGFB2 ARAF ARAF NRAS NRAS AKT1 AKT1 IKBKG IKBKG BCL2L1 BCL2L1 HDAC2 HDAC2 TP53 TP53 AKT3 AKT3 CTBP1 CTBP1 GADD45A GADD45A SOS2 SOS2 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
RB1RB transcriptional corepressor 1. (931 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
E2F2E2F transcription factor 2. (437 aa)
POLKDNA polymerase kappa. (905 aa)
CBLCbl proto-oncogene. (932 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
SHC3SHC adaptor protein 3. (592 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SHC1SHC adaptor protein 1. (583 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SHC4SHC adaptor protein 4. (630 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
MECOMMDS1 and EVI1 complex locus. (1123 aa)
BADBCL2 associated agonist of cell death. (198 aa)
E2F1E2F transcription factor 1. (441 aa)
PIK3R3Uncharacterized protein. (461 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
GAB2GRB2 associated binding protein 2. (680 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
BCRBCR activator of RhoGEF and GTPase. (1130 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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