STRINGSTRING
COL4A5 COL4A5 COL4A6 COL4A6 LAMB3 LAMB3 RB1 RB1 LAMA1 LAMA1 CDKN1A CDKN1A TRAF2 TRAF2 PTEN PTEN E2F2 E2F2 POLK POLK NFKB1 NFKB1 ITGAV ITGAV NFKBIA NFKBIA RXRB RXRB CCND1 CCND1 E2F3 E2F3 ITGB1 ITGB1 LAMA5 LAMA5 LAMA2 LAMA2 MAX MAX CDK6 CDK6 ZBTB17 ZBTB17 CASP9 CASP9 GADD45B GADD45B XIAP XIAP RARB RARB BIRC3 BIRC3 CKS1B CKS1B ITGA6 ITGA6 CASP3 CASP3 LAMA3 LAMA3 MYC MYC PTK2 PTK2 IKBKB IKBKB LAMC1 LAMC1 ITGA2B ITGA2B RELA RELA AKT2 AKT2 ITGA3 ITGA3 LAMB2 LAMB2 E2F1 E2F1 PIK3R3 PIK3R3 TRAF6 TRAF6 CDKN1B CDKN1B PIK3CA PIK3CA BAK1 BAK1 BCL2 BCL2 BAX BAX GADD45G GADD45G TRAF5 TRAF5 CHUK CHUK BIRC2 BIRC2 TRAF1 TRAF1 SKP2 SKP2 LAMA4 LAMA4 PIK3CB PIK3CB PIK3CD PIK3CD CDK4 CDK4 PIK3R1 PIK3R1 DDB2 DDB2 FN1 FN1 COL4A1 COL4A1 CKS2 CKS2 CCNE2 CCNE2 NOS2 NOS2 AKT1 AKT1 PTGS2 PTGS2 IKBKG IKBKG RXRA RXRA BCL2L1 BCL2L1 CCNE1 CCNE1 TP53 TP53 AKT3 AKT3 GADD45A GADD45A COL4A4 COL4A4 LAMC3 LAMC3 CDKN2B CDKN2B LOC102173997 LOC102173997 LAMB1 LAMB1 APAF1 APAF1 LOC106501717 LOC106501717 LAMC2 LAMC2 TRAF3 TRAF3 RXRG RXRG ITGA2 ITGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL4A5Collagen IV NC1 domain-containing protein. (568 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
RB1RB transcriptional corepressor 1. (931 aa)
LAMA1Uncharacterized protein. (530 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
TRAF2TNF receptor-associated factor. (497 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
E2F2E2F transcription factor 2. (437 aa)
POLKDNA polymerase kappa. (905 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RXRBRetinoid X receptor beta. (533 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
LAMA2Laminin subunit alpha 2. (3116 aa)
MAXMYC associated factor X. (163 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ZBTB17Zinc finger and BTB domain containing 17. (833 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
RARBRetinoic acid receptor beta. (448 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
LAMA3Laminin subunit alpha 3. (3339 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1030 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
E2F1E2F transcription factor 1. (441 aa)
PIK3R3Uncharacterized protein. (461 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
BIRC2Baculoviral IAP repeat containing 2. (623 aa)
TRAF1TNF receptor-associated factor. (410 aa)
SKP2F-box domain-containing protein. (424 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
FN1Fibronectin 1. (2478 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1154 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
RXRANR LBD domain-containing protein. (106 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
COL4A4Collagen type IV alpha 4 chain. (1434 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMB1Laminin subunit beta 1. (1842 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMC2Laminin subunit gamma 2. (1187 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
RXRGRetinoid X receptor gamma. (539 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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