62 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	RB1	RB transcriptional corepressor 1. (931 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	E2F2	E2F transcription factor 2. (437 aa)
	POLK	DNA polymerase kappa. (905 aa)
	ALK	Tyrosine-protein kinase receptor. (1309 aa)
	JAK3	Tyrosine-protein kinase. (1138 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	RXRB	Retinoid X receptor beta. (533 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	E2F3	E2F_TDP domain-containing protein. (460 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (557 aa)
	BAD	BCL2 associated agonist of cell death. (198 aa)
	E2F1	E2F transcription factor 1. (441 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
	EML4	EMAP like 4. (1006 aa)
	TGFA	Transforming growth factor alpha. (215 aa)
	FOXO3	Forkhead box O3. (672 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	RASSF5	Ras association domain family member 5. (420 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	RASSF1	Ras association domain family member 1. (340 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	DDB2	Damage specific DNA binding protein 2. (411 aa)
	STAT5B	Signal transducer and activator of transcription. (808 aa)
	STAT5A	Signal transducer and activator of transcription. (810 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (611 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
	RXRA	NR LBD domain-containing protein. (106 aa)
	PRKCA	Uncharacterized protein. (605 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1384 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RXRG	Retinoid X receptor gamma. (539 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSCHIP00000027335	ENSCHIP00000013931	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.946
AKT1	AKT3	ENSCHIP00000027335	ENSCHIP00000030504	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT1	BAD	ENSCHIP00000027335	ENSCHIP00000014347	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.957
AKT1	CASP9	ENSCHIP00000027335	ENSCHIP00000008590	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.971
AKT1	CCND1	ENSCHIP00000027335	ENSCHIP00000006815	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.679
AKT1	CDK4	ENSCHIP00000027335	ENSCHIP00000022710	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.417
AKT1	CDKN1A	ENSCHIP00000027335	ENSCHIP00000002564	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.969
AKT1	EGFR	ENSCHIP00000027335	ENSCHIP00000022759	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.507
AKT1	ERBB2	ENSCHIP00000027335	ENSCHIP00000031717	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.474
AKT1	FOXO3	ENSCHIP00000027335	ENSCHIP00000019148	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.985
AKT1	GRB2	ENSCHIP00000027335	ENSCHIP00000015407	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.530
AKT1	HRAS	ENSCHIP00000027335	ENSCHIP00000002180	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	HRas proto-oncogene, GTPase.	0.647
AKT1	KRAS	ENSCHIP00000027335	ENSCHIP00000032733	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	KRAS proto-oncogene, GTPase.	0.675
AKT1	MAP2K2	ENSCHIP00000027335	ENSCHIP00000013571	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.402
AKT1	MAPK1	ENSCHIP00000027335	ENSCHIP00000000204	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.947
AKT1	MAPK3	ENSCHIP00000027335	ENSCHIP00000015503	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.949
AKT1	NRAS	ENSCHIP00000027335	ENSCHIP00000027121	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NRAS proto-oncogene, GTPase.	0.632
AKT1	PDPK1	ENSCHIP00000027335	ENSCHIP00000014224	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.992
AKT1	PIK3CA	ENSCHIP00000027335	ENSCHIP00000015546	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.985
AKT1	PIK3CB	ENSCHIP00000027335	ENSCHIP00000021397	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.964