56 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	RORC	RAR related orphan receptor C. (508 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (378 aa)
	IL17F	Uncharacterized protein. (178 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (278 aa)
	LOC102186442	Ig-like domain-containing protein. (290 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	IL18R1	Interleukin 18 receptor 1. (538 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (270 aa)
	IL23A	Interleukin 23 subunit alpha. (190 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	LOC106503481	Ig-like domain-containing protein. (274 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
	LOC102179937	Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
	IFNGR1	Interferon gamma receptor 1. (500 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (332 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (571 aa)
	LOC102180664	Ig-like domain-containing protein. (266 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	IL10	Interleukin 10. (177 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
	IFNGR2	Interferon gamma receptor 2. (355 aa)
	IL22	Interleukin 22. (190 aa)
	ENSCHIP00000019274	Ig-like domain-containing protein. (253 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (585 aa)
	IL13	Interleukin 13. (131 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IL4R	Interleukin 4 receptor. (805 aa)
	STAT4	Signal transducer and activator of transcription. (797 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1002 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TBX21	T-box transcription factor 21. (533 aa)
	LOC102186727	Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
	IL17A	Interleukin-17A. (153 aa)
	MAF	MAF bZIP transcription factor; Belongs to the bZIP family. (404 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
	IL23R	Interleukin 23 receptor. (642 aa)
	IL21R	Interleukin 21 receptor. (531 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
	NOD2	Uncharacterized protein. (982 aa)
	GATA3	GATA binding protein 3. (467 aa)
	STAT6	Signal transducer and activator of transcription. (841 aa)
	RORA	Uncharacterized protein. (527 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
	LOC102187998	Ig-like domain-containing protein. (262 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (877 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (730 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHIP00000019274	HLA-DMA	ENSCHIP00000019274	ENSCHIP00000005445	Ig-like domain-containing protein.	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family.	0.848
ENSCHIP00000019274	HLA-DOA	ENSCHIP00000019274	ENSCHIP00000012593	Ig-like domain-containing protein.	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	0.885
ENSCHIP00000019274	HLA-DOB	ENSCHIP00000019274	ENSCHIP00000006821	Ig-like domain-containing protein.	Major histocompatibility complex, class II, DO beta.	0.728
ENSCHIP00000019274	HLA-DRA	ENSCHIP00000019274	ENSCHIP00000010819	Ig-like domain-containing protein.	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.904
ENSCHIP00000019274	LOC102179937	ENSCHIP00000019274	ENSCHIP00000011043	Ig-like domain-containing protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.865
ENSCHIP00000019274	LOC102180664	ENSCHIP00000019274	ENSCHIP00000015668	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.686
ENSCHIP00000019274	LOC102186442	ENSCHIP00000019274	ENSCHIP00000005615	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.695
ENSCHIP00000019274	LOC102186727	ENSCHIP00000019274	ENSCHIP00000025356	Ig-like domain-containing protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.882
ENSCHIP00000019274	LOC102187998	ENSCHIP00000019274	ENSCHIP00000032605	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.860
ENSCHIP00000019274	LOC106503481	ENSCHIP00000019274	ENSCHIP00000010653	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.695
GATA3	IFNG	ENSCHIP00000030187	ENSCHIP00000016152	GATA binding protein 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.869
GATA3	IL10	ENSCHIP00000030187	ENSCHIP00000016929	GATA binding protein 3.	Interleukin 10.	0.806
GATA3	IL12RB2	ENSCHIP00000030187	ENSCHIP00000033076	GATA binding protein 3.	Interleukin 12 receptor subunit beta 2.	0.427
GATA3	IL13	ENSCHIP00000030187	ENSCHIP00000021940	GATA binding protein 3.	Interleukin 13.	0.845
GATA3	IL17A	ENSCHIP00000030187	ENSCHIP00000025484	GATA binding protein 3.	Interleukin-17A.	0.769
GATA3	IL17F	ENSCHIP00000030187	ENSCHIP00000004124	GATA binding protein 3.	Uncharacterized protein.	0.663
GATA3	IL18	ENSCHIP00000030187	ENSCHIP00000023420	GATA binding protein 3.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.472
GATA3	IL1B	ENSCHIP00000030187	ENSCHIP00000029274	GATA binding protein 3.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.553
GATA3	IL2	ENSCHIP00000030187	ENSCHIP00000029633	GATA binding protein 3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.777
GATA3	IL21	ENSCHIP00000030187	ENSCHIP00000027068	GATA binding protein 3.	Interleukin; Belongs to the IL-15/IL-21 family.	0.532