STRINGSTRING
TGFB3 TGFB3 ATP6V1E2 ATP6V1E2 LOC108638246 LOC108638246 JUN JUN TNFSF13B TNFSF13B ATP6AP1 ATP6AP1 PTH PTH CTLA4 CTLA4 ATP6V1F ATP6V1F CTSV CTSV VEGFA VEGFA HLA-DMA HLA-DMA CD80 CD80 LOC102186442 LOC102186442 ATP6V1G3 ATP6V1G3 MMP1 MMP1 HLA-DOB HLA-DOB IL23A IL23A CXCL12 CXCL12 CTSK CTSK ATP6V0E2 ATP6V0E2 TGFB1 TGFB1 IL6 IL6 ITGAL ITGAL LOC106503481 LOC106503481 HLA-DRA HLA-DRA LOC102179937 LOC102179937 TEK TEK ITGB2 ITGB2 ATP6V0A2 ATP6V0A2 LOC102182395 LOC102182395 HLA-DOA HLA-DOA ATP6V1B1 ATP6V1B1 ACP5 ACP5 LOC102179590 LOC102179590 TNFSF11 TNFSF11 CCL20 CCL20 ATP6V1G1 ATP6V1G1 ANGPT1 ANGPT1 ICAM1 ICAM1 LOC102180664 LOC102180664 ATP6V1H ATP6V1H IFNG IFNG CCL5 CCL5 ATP6V1B2 ATP6V1B2 LOC102181154 LOC102181154 IL11 IL11 ATP6V1C2 ATP6V1C2 ATP6V0B ATP6V0B ATP6V0D1 ATP6V0D1 ATP6V1C1 ATP6V1C1 ENSCHIP00000019274 ENSCHIP00000019274 TLR4 TLR4 FLT1 FLT1 CXCL8 CXCL8 LOC102185906 LOC102185906 ATP6V1A ATP6V1A CTSL CTSL IL18 IL18 LOC102170772 LOC102170772 TCIRG1 TCIRG1 LOC102186727 LOC102186727 IL17A IL17A ATP6V0D2 ATP6V0D2 MMP3 MMP3 TGFB2 TGFB2 ATP6V1E1 ATP6V1E1 ATP6V0C ATP6V0C CCL2 CCL2 ATP6V0A1 ATP6V0A1 LOC102182683 LOC102182683 ATP6V1G2 ATP6V1G2 ATP6V0A4 ATP6V0A4 IL1B IL1B IL15 IL15 CD28 CD28 FOS FOS TNFRSF11A TNFRSF11A TLR2 TLR2 LOC102187998 LOC102187998 CSF1 CSF1 CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
LOC108638246C-C motif chemokine. (93 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
CTSVUncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (278 aa)
CD80CD80 molecule. (302 aa)
LOC102186442Ig-like domain-containing protein. (290 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MMP1Matrix metallopeptidase 1. (475 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (270 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1178 aa)
LOC106503481Ig-like domain-containing protein. (274 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
LOC102179937Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (774 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
LOC102182395C-X-C motif chemokine. (103 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (332 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
LOC102179590C-C motif chemokine. (89 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
CCL20C-C motif chemokine. (96 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ANGPT1Angiopoietin 1. (488 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
LOC102180664Ig-like domain-containing protein. (266 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CCL5C-C motif chemokine. (91 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
LOC102181154C-C motif chemokine. (93 aa)
IL11Interleukin 11. (191 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
ENSCHIP00000019274Ig-like domain-containing protein. (253 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC102185906Uncharacterized protein. (239 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LOC102170772C-C motif chemokine. (105 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
LOC102186727Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
IL17AInterleukin-17A. (153 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CCL2C-C motif chemokine. (98 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
CD28CD28 molecule. (228 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TNFRSF11ATNF receptor superfamily member 11a. (588 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.