STRINGSTRING
PRF1 PRF1 LOC102182286 LOC102182286 LOC102172138 LOC102172138 HLA-DMA HLA-DMA CD80 CD80 LOC108633459 LOC108633459 LOC102186442 LOC102186442 LOC102182573 LOC102182573 HLA-DOB HLA-DOB LOC108633460 LOC108633460 LOC102182856 LOC102182856 IL6 IL6 LOC102169753 LOC102169753 LOC106503481 LOC106503481 HLA-DRA HLA-DRA LOC102179937 LOC102179937 HLA-DOA HLA-DOA LOC102176878 LOC102176878 LOC102175759 LOC102175759 LOC102180664 LOC102180664 LOC102168343 LOC102168343 IFNG IFNG LOC102171703 LOC102171703 LOC106503874 LOC106503874 LOC102177285 LOC102177285 LOC108633505 LOC108633505 ENSCHIP00000019274 ENSCHIP00000019274 ENSCHIP00000020123 ENSCHIP00000020123 LOC102176782 LOC102176782 LOC102181202 LOC102181202 LOC102189064 LOC102189064 LOC102176598 LOC102176598 LOC108633178 LOC108633178 LOC102181347 LOC102181347 LOC102190602 LOC102190602 LOC102189305 LOC102189305 ENSCHIP00000024897 ENSCHIP00000024897 LOC108638467 LOC108638467 LOC102186727 LOC102186727 LOC108638461 LOC108638461 FASLG FASLG LOC102185917 LOC102185917 LOC102168905 LOC102168905 IL1B IL1B CD28 CD28 LOC102188814 LOC102188814 IL2 IL2 LOC102187998 LOC102187998
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRF1Perforin 1. (554 aa)
LOC102182286C-type lectin domain-containing protein. (197 aa)
LOC102172138Ig-like domain-containing protein; Belongs to the MHC class I family. (360 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (278 aa)
CD80CD80 molecule. (302 aa)
LOC108633459Ig-like domain-containing protein; Belongs to the MHC class I family. (369 aa)
LOC102186442Ig-like domain-containing protein. (290 aa)
LOC102182573C-type lectin domain-containing protein. (236 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (270 aa)
LOC108633460Ig-like domain-containing protein; Belongs to the MHC class I family. (383 aa)
LOC102182856C-type lectin domain-containing protein. (236 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC102169753Ig-like domain-containing protein; Belongs to the MHC class I family. (382 aa)
LOC106503481Ig-like domain-containing protein. (274 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
LOC102179937Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (332 aa)
LOC102176878Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC102175759Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
LOC102180664Ig-like domain-containing protein. (266 aa)
LOC102168343Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
LOC102171703Ig-like domain-containing protein; Belongs to the MHC class I family. (382 aa)
LOC106503874Ig-like domain-containing protein. (419 aa)
LOC102177285Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
LOC108633505Ig-like domain-containing protein; Belongs to the MHC class I family. (324 aa)
ENSCHIP00000019274Ig-like domain-containing protein. (253 aa)
ENSCHIP00000020123Ig-like domain-containing protein; Belongs to the MHC class I family. (348 aa)
LOC102176782Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
LOC102181202Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
LOC102189064Uncharacterized protein. (369 aa)
LOC102176598Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
LOC108633178Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
LOC102181347Ig-like domain-containing protein; Belongs to the MHC class I family. (374 aa)
LOC102190602Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC102189305Ig-like domain-containing protein. (448 aa)
ENSCHIP00000024897Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
LOC108638467Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
LOC102186727Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
LOC108638461Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
LOC102185917Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
LOC102168905Ig-like domain-containing protein; Belongs to the MHC class I family. (375 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD28CD28 molecule. (228 aa)
LOC102188814Ig-like domain-containing protein; Belongs to the MHC class I family. (360 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.