(27 nodes) Primary immunodeficiency network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (378 aa)
	CD3D	CD3d molecule. (167 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
	JAK3	Tyrosine-protein kinase. (1138 aa)
	RAG2	Recombination activating 2. (527 aa)
	CD4	CD4 molecule. (455 aa)
	ZAP70	Tyrosine-protein kinase. (622 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	CD79A	CD79a molecule. (223 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	DCLRE1C	DNA cross-link repair 1C. (710 aa)
	AIRE	Autoimmune regulator. (548 aa)
	TAP2	Uncharacterized protein. (719 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (306 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1129 aa)
	CD8B	Ig-like domain-containing protein. (207 aa)
	RFX5	Regulatory factor X5. (615 aa)
	IL7R	Interleukin 7 receptor. (459 aa)
	BTK	Tyrosine-protein kinase. (658 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (750 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
	CD40	CD40 molecule. (280 aa)
	ICOS	Inducible T cell costimulator. (209 aa)
	CD8A	CD8a molecule. (233 aa)
	ADA	Adenosine deaminase. (400 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	CD4	ENSCHIP00000033539	ENSCHIP00000006662	Adenosine deaminase.	CD4 molecule.	0.522
AICDA	BTK	ENSCHIP00000009604	ENSCHIP00000023722	Activation induced cytidine deaminase.	Tyrosine-protein kinase.	0.416
AICDA	CD4	ENSCHIP00000009604	ENSCHIP00000006662	Activation induced cytidine deaminase.	CD4 molecule.	0.821
AICDA	CD40	ENSCHIP00000009604	ENSCHIP00000028995	Activation induced cytidine deaminase.	CD40 molecule.	0.878
AICDA	CD40LG	ENSCHIP00000009604	ENSCHIP00000000228	Activation induced cytidine deaminase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.867
AICDA	CD79A	ENSCHIP00000009604	ENSCHIP00000011491	Activation induced cytidine deaminase.	CD79a molecule.	0.533
AICDA	ICOS	ENSCHIP00000009604	ENSCHIP00000030042	Activation induced cytidine deaminase.	Inducible T cell costimulator.	0.459
AICDA	RAG1	ENSCHIP00000009604	ENSCHIP00000010907	Activation induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.600
AICDA	RAG2	ENSCHIP00000009604	ENSCHIP00000005072	Activation induced cytidine deaminase.	Recombination activating 2.	0.559
AICDA	UNG	ENSCHIP00000009604	ENSCHIP00000004039	Activation induced cytidine deaminase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.916
AIRE	CD4	ENSCHIP00000017845	ENSCHIP00000006662	Autoimmune regulator.	CD4 molecule.	0.817
AIRE	CD40	ENSCHIP00000017845	ENSCHIP00000028995	Autoimmune regulator.	CD40 molecule.	0.649
AIRE	CD40LG	ENSCHIP00000017845	ENSCHIP00000000228	Autoimmune regulator.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.446
AIRE	RAG2	ENSCHIP00000017845	ENSCHIP00000005072	Autoimmune regulator.	Recombination activating 2.	0.511
BTK	AICDA	ENSCHIP00000023722	ENSCHIP00000009604	Tyrosine-protein kinase.	Activation induced cytidine deaminase.	0.416
BTK	CD3D	ENSCHIP00000023722	ENSCHIP00000002968	Tyrosine-protein kinase.	CD3d molecule.	0.471
BTK	CD4	ENSCHIP00000023722	ENSCHIP00000006662	Tyrosine-protein kinase.	CD4 molecule.	0.687
BTK	CD40	ENSCHIP00000023722	ENSCHIP00000028995	Tyrosine-protein kinase.	CD40 molecule.	0.660
BTK	CD40LG	ENSCHIP00000023722	ENSCHIP00000000228	Tyrosine-protein kinase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.623
BTK	CD79A	ENSCHIP00000023722	ENSCHIP00000011491	Tyrosine-protein kinase.	CD79a molecule.	0.857