70 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CACNB2	Calcium voltage-gated channel auxiliary subunit beta 2. (613 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	LAMA1	Uncharacterized protein. (530 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
	CTNNA1	Catenin alpha 1. (1018 aa)
	CACNG6	Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
	DES	Desmin; Belongs to the intermediate filament family. (470 aa)
	TCF7L2	Transcription factor 7 like 2. (669 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
	ACTN2	Actinin alpha 2. (902 aa)
	TCF7L1	Transcription factor 7 like 1. (587 aa)
	SGCG	Sarcoglycan gamma. (291 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (223 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
	LAMA2	Laminin subunit alpha 2. (3116 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	CACNB3	Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
	ENSCHIP00000009957	Calponin-homology (CH) domain-containing protein. (123 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1809 aa)
	DSP	Desmoplakin. (2892 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (902 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (844 aa)
	CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1151 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1030 aa)
	SGCA	Sarcoglycan alpha. (388 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
	PKP2	Plakophilin 2. (851 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (888 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2092 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
	DAG1	Dystroglycan 1. (895 aa)
	CACNA2D4	Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1106 aa)
	CTNNA3	Uncharacterized protein. (530 aa)
	DSG2	Desmoglein 2. (1119 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1034 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (426 aa)
	SGCD	Sarcoglycan delta. (289 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (772 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2110 aa)
	DSC2	Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (909 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (650 aa)
	EMD	Emerin. (261 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	CACNA2D3	Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
	CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1098 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1029 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1026 aa)
	ITGA11	Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1209 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SGCB	Sarcoglycan beta. (320 aa)
	JUP	Junction plakoglobin. (745 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
	CTNNA2	Uncharacterized protein. (394 aa)
	ITGA10	Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1178 aa)
	RYR2	Ryanodine receptor 2. (4943 aa)
	TCF7	Transcription factor 7. (418 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN2	ENSCHIP00000011080	ENSCHIP00000006208	Uncharacterized protein.	Actinin alpha 2.	0.501
ACTB	ACTN3	ENSCHIP00000011080	ENSCHIP00000011760	Uncharacterized protein.	Actinin alpha 3 (gene/pseudogene).	0.454
ACTB	CDH2	ENSCHIP00000011080	ENSCHIP00000019820	Uncharacterized protein.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.727
ACTB	CTNNA1	ENSCHIP00000011080	ENSCHIP00000002514	Uncharacterized protein.	Catenin alpha 1.	0.945
ACTB	CTNNA2	ENSCHIP00000011080	ENSCHIP00000033099	Uncharacterized protein.	Uncharacterized protein.	0.923
ACTB	CTNNA3	ENSCHIP00000011080	ENSCHIP00000015430	Uncharacterized protein.	Uncharacterized protein.	0.923
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	DSP	ENSCHIP00000011080	ENSCHIP00000011508	Uncharacterized protein.	Desmoplakin.	0.423
ACTB	ENSCHIP00000009957	ENSCHIP00000011080	ENSCHIP00000009957	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.421
ACTB	GJA1	ENSCHIP00000011080	ENSCHIP00000001879	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.665
ACTB	ITGA1	ENSCHIP00000011080	ENSCHIP00000023916	Uncharacterized protein.	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	0.942
ACTB	ITGA10	ENSCHIP00000011080	ENSCHIP00000033498	Uncharacterized protein.	Integrin subunit alpha 10; Belongs to the integrin alpha chain family.	0.918
ACTB	ITGA11	ENSCHIP00000011080	ENSCHIP00000030685	Uncharacterized protein.	Integrin subunit alpha 11; Belongs to the integrin alpha chain family.	0.928
ACTB	ITGA2	ENSCHIP00000011080	ENSCHIP00000032957	Uncharacterized protein.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.952
ACTB	ITGA2B	ENSCHIP00000011080	ENSCHIP00000012900	Uncharacterized protein.	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.916
ACTB	ITGA3	ENSCHIP00000011080	ENSCHIP00000014116	Uncharacterized protein.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.934
ACTB	ITGA4	ENSCHIP00000011080	ENSCHIP00000020850	Uncharacterized protein.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.939
ACTB	ITGA5	ENSCHIP00000011080	ENSCHIP00000012972	Uncharacterized protein.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.956
ACTB	ITGA6	ENSCHIP00000011080	ENSCHIP00000010556	Uncharacterized protein.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.948
ACTB	ITGA7	ENSCHIP00000011080	ENSCHIP00000027920	Uncharacterized protein.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.921