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pgpA pgpA ybhN ybhN ybhO ybhO ybhP ybhP ybhQ ybhQ ymdC ymdC pgpB pgpB cls cls pgsA pgsA yegS yegS glpQ glpQ glpT glpT glpA glpA glpB glpB glpC glpC yfhB yfhB pssA pssA ygeD ygeD aas aas plsC plsC ygiH ygiH glpD glpD gpsA gpsA pldA pldA pldB pldB yigL yigL yigM yigM ushB ushB STM4069 STM4069 STM4070 STM4070 glpK glpK glpF glpF plsB plsB dgkA dgkA psd psd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pgpAPhosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (171 aa)
ybhNPutative negative regulator; Similar to E. coli orf, hypothetical protein (AAC73875.1); Blastp hit to AAC73875.1 (318 aa), 89% identity in aa 1 - 318. (320 aa)
ybhOCardiolipin (CL) synthase; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (413 aa)
ybhPPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73877.1); Blastp hit to AAC73877.1 (253 aa), 86% identity in aa 1 - 253. (252 aa)
ybhQPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC73878.1); Blastp hit to AAC73878.1 (136 aa), 84% identity in aa 1 - 136. (136 aa)
ymdCPutative phospholipase; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE); Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. (494 aa)
pgpBSimilar to E. coli non-essential phosphatidylglycerophosphate phosphatase, membrane bound (AAC74360.1); Blastp hit to AAC74360.1 (254 aa), 82% identity in aa 1 - 254. (254 aa)
clsCardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa)
pgsAPhosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa)
yegSPutative diacylglycerol kinase catalytic domain containing protein; In vitro does not phosphorylate diacylglycerol, sphingosine, N,N-dimethylsphingosine; threo-dihydrosphingosine, erythro- dihydrosphingosine, C2 ceramide, C6 ceramide, phosphatidylinositol or dimethylsphingosine. The potential in vivo substrate is unknown. (299 aa)
glpQSimilar to E. coli glycerophosphodiester phosphodiesterase, periplasmic (AAC75299.1); Blastp hit to AAC75299.1 (358 aa), 89% identity in aa 1 - 357. (356 aa)
glpTMFS family, sn-glycerol-3-phosphate transport protein; Similar to E. coli sn-glycerol-3-phosphate permease (AAC75300.1); Blastp hit to AAC75300.1 (452 aa), 96% identity in aa 1 - 452. (452 aa)
glpASimilar to E. coli sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit (AAC75301.1); Blastp hit to AAC75301.1 (542 aa), 92% identity in aa 1 - 542; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
glpBSn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family. (419 aa)
glpCSimilar to E. coli sn-glycerol-3-phosphate dehydrogenase (anaerobic), K-small subunit (AAC75303.1); Blastp hit to AAC75303.1 (396 aa), 94% identity in aa 1 - 395. (396 aa)
yfhBPutatative phosphoserine phosphatase; Similar to E. coli orf, hypothetical protein (AAC75613.1); Blastp hit to AAC75613.1 (190 aa), 91% identity in aa 1 - 190. (211 aa)
pssAPhosphatidylserine synthase; CDP-diacylglycerol-serine O-phosphatidyltransferase; similar to E. coli phosphatidylserine synthase; phospholipid synthesis (AAC75638.1); Blastp hit to AAC75638.1 (452 aa), 93% identity in aa 2 - 452. (451 aa)
ygeDPutative efflux protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (400 aa)
aas2-acylglycerophospho-ethanolamine acyl transferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. (719 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl-carrier-protein as the fatty acyl donor. (245 aa)
ygiHPutative inner membrane protein; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4); Belongs to the PlsY family. (203 aa)
glpDAerobic; similar to E. coli sn-glycerol-3-phosphate dehydrogenase (aerobic) (AAC76451.1); Blastp hit to AAC76451.1 (501 aa), 90% identity in aa 1 - 501; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (502 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD+]. (SW:GPDA_SALTY); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
pldAOuter membrane phospholipase A; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities; Belongs to the phospholipase A1 family. (289 aa)
pldBSimilar to E. coli lysophospholipase L(2) (AAC76828.1); Blastp hit to AAC76828.1 (340 aa), 81% identity in aa 1 - 336. (338 aa)
yigLPutative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC76829.1); Blastp hit to AAC76829.1 (171 aa), 85% identity in aa 1 - 167. (266 aa)
yigMPutative transport protein; Uptake of biotin; Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. (299 aa)
ushBCDP-diacylglycerol pyrophosphatase. (SW:CDH_SALTY). (251 aa)
STM4069Putative periplasmic protein. (54 aa)
STM4070Putative cytoplasmic protein; Similar to E. coli CDP-diacylglycerol phosphotidylhydrolase (AAC76900.1); Blastp hit to AAC76900.1 (251 aa), 81% identity in aa 214 - 250. (43 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa)
glpFSimilar to E. coli facilitated diffusion of glycerol (AAC76909.1); Blastp hit to AAC76909.1 (281 aa), 92% identity in aa 1 - 281; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa)
plsBGlycerolphosphate acyltransferase activity; Similar to E. coli glycerol-3-phosphate acyltransferase (AAC77011.1); Blastp hit to AAC77011.1 (827 aa), 94% identity in aa 21 - 826; Belongs to the GPAT/DAPAT family. (806 aa)
dgkADiacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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