(36 nodes) Mostly uncharacterized, incl. Prokaryotic N-terminal methylation site, and Leader peptide network (Salmonella enterica Typhimurium)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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textmining

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Your Input:
	leuL	Leu operon leader peptide; Involved in control of the biosynthesis of leucine. (28 aa)
	hofC	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400. (400 aa)
	hofB	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459. (461 aa)
	ppdD	Prelipin peptidase dependent protein; Putative major component of type IV pilin; similar to E. coli prelipin peptidase dependent protein (AAC73219.1); Blastp hit to AAC73219.1 (146 aa), 89% identity in aa 1 - 146. (145 aa)
	cypD	Peptidyl prolyl isomerase; Similar to E. coli putative protease maturation protein (AAC73544.1); Blastp hit to AAC73544.1 (623 aa), 88% identity in aa 1 - 623. (623 aa)
	ybaV	Putative DNA uptake protein and related DNA-binding proteins; Similar to E. coli orf, hypothetical protein (AAC73545.1); Blastp hit to AAC73545.1 (123 aa), 83% identity in aa 1 - 123. (124 aa)
	ybaW	Putative esterase; Similar to E. coli orf, hypothetical protein (AAC73546.1); Blastp hit to AAC73546.1 (132 aa), 94% identity in aa 1 - 132. (132 aa)
	ycaI	Putative recombination protein; Similar to E. coli orf, hypothetical protein (AAC73999.1); Blastp hit to AAC73999.1 (780 aa), 70% identity in aa 27 - 780. (754 aa)
	ppdC	Prepilin peptidase dependent protein C; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein C (AAC75862.1); Blastp hit to AAC75862.1 (107 aa), 69% identity in aa 1 - 106. (106 aa)
	ygdB	Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75863.1); Blastp hit to AAC75863.1 (121 aa), 52% identity in aa 1 - 121. (135 aa)
	ppdB	Prepilin peptidase dependent protein B; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein B (AAC75864.1); Blastp hit to AAC75864.1 (187 aa), 67% identity in aa 3 - 187. (187 aa)
	ppdA	Prepilin peptidase dependent protein A; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein A (AAC75865.1); Blastp hit to AAC75865.1 (156 aa), 65% identity in aa 1 - 155. (156 aa)
	yggR	Similar to E. coli putative protein transport (AAC75987.1); Blastp hit to AAC75987.1 (341 aa), 79% identity in aa 16 - 341. (326 aa)
	yggS	Putative enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (234 aa)
	yggT	Similar to E. coli putative resistance protein (AAC75989.1); Blastp hit to AAC75989.1 (188 aa), 90% identity in aa 1 - 188. (188 aa)
	yggU	Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75990.1); Blastp hit to AAC75990.1 (100 aa), 90% identity in aa 5 - 98; Belongs to the UPF0235 family. (96 aa)
	yggV	Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
	yggW	Putative oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
	yggM	Putative periplasmic protein; Similar to E. coli putative alpha helix chain (AAC75993.1); Blastp hit to AAC75993.1 (335 aa), 64% identity in aa 3 - 335. (335 aa)
	yggN	Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75995.1); Blastp hit to AAC75995.1 (239 aa), 87% identity in aa 1 - 239. (239 aa)
	yggL	Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75996.1); Blastp hit to AAC75996.1 (118 aa), 95% identity in aa 11 - 118. (108 aa)
	mutY	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. (350 aa)
	yggX	Putative cytoplasmic protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress. (91 aa)
	smf	Putative protein involved in DNA uptake; Similar to E. coli orf, fragment 1 (AAC76311.1); Blastp hit to AAC76311.1 (253 aa), 66% identity in aa 1 - 248. (374 aa)
	hopD	Similar to E. coli leader peptidase, integral membrane protein (AAC76360.1); Blastp hit to AAC76360.1 (225 aa), 47% identity in aa 80 - 215; Belongs to the peptidase A24 family. (155 aa)
	hofQ	Putative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412. (412 aa)
	yrfA	Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76417.1); Blastp hit to AAC76417.1 (147 aa), 61% identity in aa 14 - 146. (133 aa)
	yrfB	Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76418.1); Blastp hit to AAC76418.1 (146 aa), 46% identity in aa 1 - 146. (157 aa)
	yrfC	Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76419.1); Blastp hit to AAC76419.1 (179 aa), 49% identity in aa 5 - 179. (179 aa)
	yrfD	Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76420.1); Blastp hit to AAC76420.1 (268 aa), 65% identity in aa 10 - 266. (259 aa)
	yhgH	Putative amidophosphoribosyltransferase; Could be involved in gluconate metabolism. (227 aa)
	radC	Putative DNA repair protein; Associated with replication forks; similar to E. coli DNA repair protein (AAC76662.1); Blastp hit to AAC76662.1 (224 aa), 83% identity in aa 10 - 224; Belongs to the UPF0758 family. YicR subfamily. (221 aa)
	yicC	Similar to E. coli putative alpha helix protein (AAC76668.1); Blastp hit to AAC76668.1 (287 aa), 96% identity in aa 1 - 287. (287 aa)
	yifB	Putative magnesium chelatase, subunit ChlI; Hypothetical 55.0 Kda protein in pssR-ilLl intergenic region. (SW:YIFB_SALTY); Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. (506 aa)
	ilvL	ilvGmedA operon leader peptide (attenuator peptide). (SW:LPID_ECOLI). (32 aa)
	pyrL	Pyrbi operon leader peptide (attenuator). (SW:LPPY_SALTY). (33 aa)

Your Current Organism:

Salmonella enterica Typhimurium

NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cypD	ybaV	STM0452	STM0453	Peptidyl prolyl isomerase; Similar to E. coli putative protease maturation protein (AAC73544.1); Blastp hit to AAC73544.1 (623 aa), 88% identity in aa 1 - 623.	Putative DNA uptake protein and related DNA-binding proteins; Similar to E. coli orf, hypothetical protein (AAC73545.1); Blastp hit to AAC73545.1 (123 aa), 83% identity in aa 1 - 123.	0.548
hofB	hofC	STM0143	STM0142	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.	0.999
hofB	hofQ	STM0143	STM3488	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412.	0.969
hofB	hopD	STM0143	STM3442	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Similar to E. coli leader peptidase, integral membrane protein (AAC76360.1); Blastp hit to AAC76360.1 (225 aa), 47% identity in aa 80 - 215; Belongs to the peptidase A24 family.	0.907
hofB	ppdA	STM0143	STM3000	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Prepilin peptidase dependent protein A; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein A (AAC75865.1); Blastp hit to AAC75865.1 (156 aa), 65% identity in aa 1 - 155.	0.988
hofB	ppdB	STM0143	STM2999	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Prepilin peptidase dependent protein B; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein B (AAC75864.1); Blastp hit to AAC75864.1 (187 aa), 67% identity in aa 3 - 187.	0.934
hofB	ppdC	STM0143	STM2997	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Prepilin peptidase dependent protein C; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein C (AAC75862.1); Blastp hit to AAC75862.1 (107 aa), 69% identity in aa 1 - 106.	0.928
hofB	ppdD	STM0143	STM0144	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Prelipin peptidase dependent protein; Putative major component of type IV pilin; similar to E. coli prelipin peptidase dependent protein (AAC73219.1); Blastp hit to AAC73219.1 (146 aa), 89% identity in aa 1 - 146.	0.978
hofB	smf	STM0143	STM3405	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative protein involved in DNA uptake; Similar to E. coli orf, fragment 1 (AAC76311.1); Blastp hit to AAC76311.1 (253 aa), 66% identity in aa 1 - 248.	0.705
hofB	ybaV	STM0143	STM0453	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative DNA uptake protein and related DNA-binding proteins; Similar to E. coli orf, hypothetical protein (AAC73545.1); Blastp hit to AAC73545.1 (123 aa), 83% identity in aa 1 - 123.	0.686
hofB	ycaI	STM0143	STM0983	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative recombination protein; Similar to E. coli orf, hypothetical protein (AAC73999.1); Blastp hit to AAC73999.1 (780 aa), 70% identity in aa 27 - 780.	0.730
hofB	ygdB	STM0143	STM2998	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75863.1); Blastp hit to AAC75863.1 (121 aa), 52% identity in aa 1 - 121.	0.832
hofB	yggR	STM0143	STM3099	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Similar to E. coli putative protein transport (AAC75987.1); Blastp hit to AAC75987.1 (341 aa), 79% identity in aa 16 - 341.	0.594
hofB	yhgH	STM0143	STM3510	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative amidophosphoribosyltransferase; Could be involved in gluconate metabolism.	0.515
hofB	yrfC	STM0143	STM3491	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76419.1); Blastp hit to AAC76419.1 (179 aa), 49% identity in aa 5 - 179.	0.747
hofB	yrfD	STM0143	STM3492	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76420.1); Blastp hit to AAC76420.1 (268 aa), 65% identity in aa 10 - 266.	0.687
hofC	hofB	STM0142	STM0143	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.	Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.	0.999
hofC	hofQ	STM0142	STM3488	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.	Putative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412.	0.980
hofC	hopD	STM0142	STM3442	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.	Similar to E. coli leader peptidase, integral membrane protein (AAC76360.1); Blastp hit to AAC76360.1 (225 aa), 47% identity in aa 80 - 215; Belongs to the peptidase A24 family.	0.859
hofC	ppdA	STM0142	STM3000	Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.	Prepilin peptidase dependent protein A; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein A (AAC75865.1); Blastp hit to AAC75865.1 (156 aa), 65% identity in aa 1 - 155.	0.992

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