STRINGSTRING
STM0350 STM0350 STM0351 STM0351 STM0352 STM0352 yahN yahN ybaO ybaO mdlA mdlA mdlB mdlB acrB acrB acrA acrA acrR acrR STM0479 STM0479 ybaN ybaN acrZ acrZ mdfA mdfA STM0901 STM0901 ybjY ybjY ybjZ ybjZ yceE yceE yceL yceL yeaS yeaS ydhE ydhE ydhC ydhC ydgF ydgF ydgE ydgE ydfJ ydfJ ydeD ydeD marB marB marA marA marR marR marC marC STM1530 STM1530 yddG yddG smvA smvA STM1653 STM1653 STM1843 STM1843 pagO pagO STM1863 STM1863 STM1864 STM1864 mdtA mdtA yegN yegN yegO yegO yegB yegB baeS baeS baeR baeR gyrA gyrA ypeC ypeC acrD acrD yfiK yfiK emrR emrR emrA emrA emrB emrB STM3030 STM3030 STM3031 STM3031 iciA iciA yggA yggA parC parC parE parE tolC tolC yhcP yhcP yhcQ yhcQ yhcR yhcR acrE acrE acrF acrF ysaB ysaB yiaB yiaB STM3766 STM3766 emrD emrD gyrB gyrB yidY yidY yidZ yidZ yieE yieE yieF yieF yieO yieO yigF yigF yigG yigG rarD rarD yigI yigI rhtC rhtC rthB rthB yjcB yjcB ytfF ytfF yjiO yjiO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STM0350Homology to outer membrane efflux protein; Similar to E. coli putative resistance protein (AAC73673.1); Blastp hit to AAC73673.1 (457 aa), 37% identity in aa 7 - 457. (503 aa)
STM0351Putative cation efflux system protein; Similar to E. coli integral transmembrane protein; acridine resistance (AAC76298.1); Blastp hit to AAC76298.1 (1034 aa), 42% identity in aa 3 - 1030. (1055 aa)
STM0352Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 31% identity in aa 38 - 383; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (408 aa)
yahNPutative transport protein; Similar to E. coli putative cytochrome subunit of dehydrogenase (AAC73431.1); Blastp hit to AAC73431.1 (223 aa), 86% identity in aa 14 - 223. (210 aa)
ybaOSimilar to E. coli putative LRP-like transcriptional regulator (AAC73550.1); Blastp hit to AAC73550.1 (181 aa), 95% identity in aa 30 - 181. (152 aa)
mdlAPutative ABC superfamily (atp) transporter; Similar to E. coli ATP-binding component of a transport system (AAC73551.1); Blastp hit to AAC73551.1 (590 aa), 88% identity in aa 1 - 590. (590 aa)
mdlBPutative ABC superfamily (atp&membrane) transporter; Similar to E. coli putative ATP-binding component of a transport system (AAC73552.1); Blastp hit to AAC73552.1 (593 aa), 88% identity in aa 1 - 593. (593 aa)
acrBSimilar to E. coli acridine efflux pump (AAC73564.1); Blastp hit to AAC73564.1 (1049 aa), 94% identity in aa 1 - 1048. (1049 aa)
acrASimilar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
acrRSimilar to E. coli acrAB operon repressor (AAC73566.1); Blastp hit to AAC73566.1 (215 aa), 87% identity in aa 1 - 214. (217 aa)
STM0479Putative transposase; Similar to E. coli orf, hypothetical protein (AAC75365.1); Blastp hit to AAC75365.1 (296 aa), 49% identity in aa 7 - 296. (311 aa)
ybaNSimilar to E. coli putative gene 58 (AAC73570.1); Blastp hit to AAC73570.1 (125 aa), 84% identity in aa 1 - 124. (125 aa)
acrZPutative outer membrane or exported; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)
mdfAMultidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. (410 aa)
STM0901Fels-1 putative prophage DNA primase. (322 aa)
ybjYSimilar to E. coli putative membrane protein (AAC73965.1); Blastp hit to AAC73965.1 (380 aa), 83% identity in aa 12 - 378; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (372 aa)
ybjZPutative ABC superfamily (atp&memb) transport protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
yceESimilar to E. coli putative transport protein (AAC74137.1); Blastp hit to AAC74137.1 (408 aa), 27% identity in aa 1 - 404. (404 aa)
yceLPutative MFS superfamily transport protein; Similar to E. coli orf, hypothetical protein (AAC74149.1); Blastp hit to AAC74149.1 (412 aa), 92% identity in aa 11 - 412. (402 aa)
yeaSPutative transport protein; Exporter of leucine; Belongs to the Rht family. (212 aa)
ydhEPutative MATE family transport protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
ydhCSimilar to E. coli putative transport protein (AAC74732.1); Blastp hit to AAC74732.1 (403 aa), 85% identity in aa 1 - 403. (401 aa)
ydgFPutative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine. (120 aa)
ydgEPutative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine. (109 aa)
ydfJSimilar to E. coli putative transport protein (AAC74616.1); Blastp hit to AAC74616.1 (427 aa), 86% identity in aa 1 - 293. (325 aa)
ydeDPutative permease, integral membrane protein; May be an export pump for several amino acids and their metabolites, including cysteine; Belongs to the EamA transporter family. (300 aa)
marBMultiple antibiotic resistance protein MARB. (SW:MARB_SALTY). (71 aa)
marAAraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. (144 aa)
marRTranscriptional repressor of marRAB operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. (144 aa)
marCPutative MarC Transporter; Multiple antibiotic resistance protein MARC. (SW:MARC_SALTY). (221 aa)
STM1530Similar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 61% identity in aa 2 - 377; Belongs to the Gram-negative porin family. (372 aa)
yddGPutative permease; Similar to E. coli orf, hypothetical protein (AAD13437.1); Blastp hit to AAD13437.1 (293 aa), 85% identity in aa 20 - 292. (274 aa)
smvAMethyl viologen resistance protein; Major efflux pump for acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen (By similarity); Belongs to the major facilitator superfamily. TCR/Tet family. (495 aa)
STM1653Putative membrane transporter of cations; Similar to E. coli methylviologen resistance (AAC73644.1); Blastp hit to AAC73644.1 (110 aa), 59% identity in aa 5 - 110. (112 aa)
STM1843Similar to E. coli putative transport protein (AAC74898.1); Blastp hit to AAC74898.1 (494 aa), 90% identity in aa 38 - 494. (457 aa)
pagOPredicted integral membrane protein; PAGO protein. (SW:PAGO_SALTY). (304 aa)
STM1863Putative inner membrane protein. (52 aa)
STM1864Putative inner membrane protein. (204 aa)
mdtAPutative HlyD family secretion protein; Similar to E. coli putative membrane protein (AAC75135.1); Blastp hit to AAC75135.1 (464 aa), 82% identity in aa 50 - 464; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (413 aa)
yegNPutative outer membrane receptor; Similar to E. coli orf, hypothetical protein (AAC75136.1); Blastp hit to AAC75136.1 (1040 aa), 91% identity in aa 1 - 1040; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. (1040 aa)
yegOPutative resistance protein; Efflux transporter; outer membrane; similar to E. coli orf, hypothetical protein (AAC75137.1); Blastp hit to AAC75137.1 (1025 aa), 91% identity in aa 1 - 1025; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. (1026 aa)
yegBSimilar to E. coli putative transport protein (AAC75138.1); Blastp hit to AAC75138.1 (471 aa), 85% identity in aa 1 - 469. (470 aa)
baeSSensory kinase in two-component regulatoyr system wtih BaeR; Similar to E. coli sensor protein (for BaeR) (AAC75139.1); Blastp hit to AAC75139.1 (467 aa), 88% identity in aa 1 - 467. (467 aa)
baeROmpR family; similar to E. coli transcriptional response regulatory protein (sensor BaeS) (AAC75140.1); Blastp hit to AAC75140.1 (240 aa), 96% identity in aa 1 - 240. (240 aa)
gyrADNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] (878 aa)
ypeCPutative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75449.1); Blastp hit to AAC75449.1 (108 aa), 91% identity in aa 1 - 108. (108 aa)
acrDRND family aminoglycoside/multidrug efflux pump; Similar to E. coli sensitivity to acriflavine, integral membrane protein, possible efflux pump (AAC75523.1); Blastp hit to AAC75523.1 (1037 aa), 94% identity in aa 1 - 1037. (1037 aa)
yfiKPutative transport protein; Exporter of O-acetylserine (OAS) and cysteine; Belongs to the Rht family. (195 aa)
emrRTranscriptional repressor of emrAB operon; MarR family; similar to E. coli regulator of plasmid mcrB operon (microcin B17 synthesis) (AAC75731.1); Blastp hit to AAC75731.1 (176 aa), 93% identity in aa 1 - 175. (176 aa)
emrASimilar to E. coli multidrug resistance secretion protein (AAC75732.1); Blastp hit to AAC75732.1 (390 aa), 89% identity in aa 1 - 390. (390 aa)
emrBPutative MFS superfamily multidrug transport protein; Similar to E. coli multidrug resistance; probably membrane translocase (AAC75733.1); Blastp hit to AAC75733.1 (512 aa), 95% identity in aa 1 - 512; Belongs to the major facilitator superfamily. (512 aa)
STM3030Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75434.1); Blastp hit to AAC75434.1 (211 aa), 46% identity in aa 47 - 208. (210 aa)
STM3031Ail and ompX-like protein; Similar to E. coli outer membrane protein X (AAC73901.1); Blastp hit to AAC73901.1 (171 aa), 29% identity in aa 1 - 171. (178 aa)
iciAInhibitor of replication initiation; Controls the transcription of genes involved in arginine and lysine metabolism; Belongs to the LysR transcriptional regulatory family. (297 aa)
yggAPutative LYSE family amino acid transport protein; Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine (By similarity); Belongs to the LysE/ArgO transporter (TC 2.A.75) family. (211 aa)
parCDNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa)
parEDNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa)
tolCOuter membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495. (491 aa)
yhcPPutative inner membrane protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. (655 aa)
yhcQPutative membrane located multidrug resistance protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (310 aa)
yhcRPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76274.1); Blastp hit to AAC76274.1 (90 aa), 98% identity in aa 24 - 90. (67 aa)
acrESimilar to E. coli transmembrane protein affects septum formation and cell membrane permeability (AAC76297.1); Blastp hit to AAC76297.1 (385 aa), 88% identity in aa 1 - 380; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
acrFRND family multidrug transport protein; Similar to E. coli integral transmembrane protein; acridine resistance (AAC76298.1); Blastp hit to AAC76298.1 (1034 aa), 22% identity in aa 1 - 506; acriflavin resistance protein F. (1037 aa)
ysaBPutative outer membrane lipoprotein. (100 aa)
yiaBPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76587.1); Blastp hit to AAC76587.1 (117 aa), 33% identity in aa 15 - 109. (117 aa)
STM3766Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75365.1); Blastp hit to AAC75365.1 (296 aa), 67% identity in aa 1 - 278, 45% identity in aa 216 - 296. (313 aa)
emrDMFS family multidrug tranport protein; Similar to E. coli 2-module integral membrane pump; multidrug resistance (AAC76696.1); Blastp hit to AAC76696.1 (396 aa), 92% identity in aa 3 - 396. (394 aa)
gyrBDNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] (804 aa)
yidYPutative MFS family tranport protein; 1st mdule; similar to E. coli putative transport protein (AAC76733.1); Blastp hit to AAC76733.1 (391 aa), 77% identity in aa 1 - 391. (395 aa)
yidZPutative LysR family transcriptional regulator; Involved in anaerobic NO protection. (319 aa)
yieEPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76735.1); Blastp hit to AAC76735.1 (253 aa), 77% identity in aa 5 - 253. (251 aa)
yieFPutative oxidoreductase; Similar to E. coli orf, hypothetical protein (AAC76736.1); Blastp hit to AAC76736.1 (188 aa), 92% identity in aa 1 - 187. (194 aa)
yieOPutative MFS family tranport protein; 1st mdule; similar to E. coli putative transport protein (AAC76777.1); Blastp hit to AAC76777.1 (475 aa), 86% identity in aa 1 - 475; Belongs to the major facilitator superfamily. (475 aa)
yigFPutative inner membrane protein; Hypothetical 14.6 Kda protein in corA-rarD intergenic region. (SW:YIGF_SALTY). (126 aa)
yigGPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76821.1); Blastp hit to AAC76821.1 (138 aa), 57% identity in aa 7 - 136. (152 aa)
rarDChloramphenicol resistance; Similar to E. coli orf, hypothetical protein (AAC76822.1); Blastp hit to AAC76822.1 (300 aa), 83% identity in aa 8 - 297. (294 aa)
yigIPutative PaaI protein; Possibly involved in aromatic compounds catabolism; hypothetical protein in rarD-pldA intergenic region. (SW:YIGI_SALTY). (161 aa)
rhtCRhtB family threonine efflux protein; Conducts the efflux of threonine; Belongs to the Rht family. (206 aa)
rthBHomoserine/homoserine lactone efflux protein; Conducts the efflux of homoserine and homoserine lactone. Belongs to the Rht family. (206 aa)
yjcBPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77030.1); Blastp hit to AAC77030.1 (116 aa), 83% identity in aa 24 - 116. (93 aa)
ytfFPutative cationic amino acid transporter; Similar to E. coli putative transmembrane subunit (AAC77167.1); Blastp hit to AAC77167.1 (324 aa), 81% identity in aa 4 - 323. (321 aa)
yjiOSimilar to E. coli putative transport protein (AAC77293.1); Blastp hit to AAC77293.1 (410 aa), 86% identity in aa 3 - 410. (413 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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