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mog mog fsr fsr dsbG dsbG STM0610 STM0610 STM0611 STM0611 STM0612 STM0612 STM0613 STM0613 rnk rnk modF modF modE modE modA modA modB modB modC modC moaA moaA moaB moaB moaC moaC moaD moaD moaE moaE ybhL ybhL ybhM ybhM STM0809 STM0809 STM0810 STM0810 moeB moeB moeA moeA hcr hcr hcp hcp dmsA dmsA dmsB dmsB dmsC dmsC scsA scsA scsB scsB scsC scsC scsD scsD yeaR yeaR yoaG yoaG yeaA yeaA selD selD ynfI ynfI STM1496 STM1496 STM1497 STM1497 STM1498 STM1498 STM1499 STM1499 hypA-2 hypA-2 STM1532 STM1532 STM1533 STM1533 STM1534 STM1534 STM1535 STM1535 STM1536 STM1536 STM1537 STM1537 STM1538 STM1538 STM1539 STM1539 fdnI fdnI fdnH fdnH fdnG fdnG narU narU narZ narZ narY narY narW narW narV narV narI narI narJ narJ narH narH narG narG narK narK narX narX narL narL STM1786 STM1786 STM1787 STM1787 STM1788 STM1788 STM1789 STM1789 STM1790 STM1790 STM1791 STM1791 dsbB dsbB STM1808 STM1808 narP narP ccmH ccmH ccmG ccmG ccmF ccmF ccmE ccmE ccmD ccmD ccmC ccmC ccmB ccmB ccmA ccmA napC napC napB napB napH napH napG napG napA napA napD napD napF napF narQ narQ STM2527 STM2527 STM2528 STM2528 STM2529 STM2529 STM2530 STM2530 hmpA hmpA yfhH yfhH STM2574 STM2574 ygaA ygaA norV norV ygbD ygbD hypF hypF hydN hydN STM2844 STM2844 hycI hycI hycH hycH hycG hycG hycF hycF hycE hycE hycD hycD hycC hycC hycB hycB hycA hycA hypA hypA hypB hypB hypC hypC hypD hypD hypE hypE ygbA ygbA dsbC dsbC STM3141 STM3141 STM3142 STM3142 hybG hybG hybF hybF hybE hybE hybD hybD hybC hybC hybB hybB hybA hybA hypO hypO STM3191 STM3191 STM3192 STM3192 dsbL dsbL dsbI dsbI yhbT yhbT yhbU yhbU yhbV yhbV yhbW yhbW yhdH yhdH msrP msrP msrQ msrQ nirB nirB nirD nirD nirC nirC cysG cysG bisC bisC ysaA ysaA selB selB selA selA yidR yidR ccmH-2 ccmH-2 ccmG-2 ccmG-2 ccmF-2 ccmF-2 ccmE-2 ccmE-2 ccmD-2 ccmD-2 ccmC-2 ccmC-2 ccmB-2 ccmB-2 ccmA-2 ccmA-2 STM3820 STM3820 torD torD torA torA torC torC torR torR torT torT torS torS STMD1.9 STMD1.9 STM3981 STM3981 mobB mobB mobA mobA dsbA dsbA fdhE fdhE fdoI fdoI fdoH fdoH fdoG fdoG fdhD fdhD STM4098 STM4098 STM4276 STM4276 nrfA nrfA nrfB nrfB nrfC nrfC nrfD nrfD nrfE nrfE nrfG nrfG fdhF fdhF STM4305 STM4305 STM4306 STM4306 STM4307 STM4307 STM4308 STM4308 dsbD dsbD yjeB yjeB ytfE ytfE msrA msrA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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mogPutative molybdochetalase; Molybdopterine biosynthesis; similar to E. coli required for the efficient incorporation of molybdate into molybdoproteins (AAC73120.1); Blastp hit to AAC73120.1 (195 aa), 91% identity in aa 1 - 192. (196 aa)
fsrPutative MFS family of transport protein; Similar to E. coli fosmidomycin resistance protein (AAC73581.1); Blastp hit to AAC73581.1 (406 aa), 93% identity in aa 1 - 405. (406 aa)
dsbGPeriplasmic disulfide isomerase, thiol-disulphide oxidase; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (248 aa)
STM0610Putative component of anaerobic dehydrogenases; Similar to E. coli putative oxidoreductase component (AAC74663.1); Blastp hit to AAC74663.1 (207 aa), 30% identity in aa 78 - 196. (186 aa)
STM0611Similar to E. coli putative oxidoreductase, major subunit (AAC74659.1); Blastp hit to AAC74659.1 (808 aa), 31% identity in aa 10 - 314, 26% identity in aa 298 - 673, 36% identity in aa 636 - 765, 34% identity in aa 489 - 517; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
STM0612Putative hydrogenase protein; Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit B (AAC73981.1); Blastp hit to AAC73981.1 (205 aa), 41% identity in aa 7 - 156. (185 aa)
STM0613Putative hydrogenase protein; Similar to E. coli putative DMSO reductase anchor subunit (AAC74662.1); Blastp hit to AAC74662.1 (284 aa), 30% identity in aa 6 - 200. (255 aa)
rnkRegulator of nucleoside diphosphate kinase; May act as an anti-Gre factor; Belongs to the Rnk family. (136 aa)
modFPutative ABC superfamily (atp_bind), molybdenum transporter; Similar to E. coli ATP-binding component of molybdate transport system (AAC73847.1); Blastp hit to AAC73847.1 (490 aa), 31% identity in aa 1 - 211. (491 aa)
modETranscriptional repressor of modABCD operon (molybdate uptake); Similar to E. coli molybdate uptake regulatory protein (AAC73848.1); Blastp hit to AAC73848.1 (262 aa), 89% identity in aa 1 - 262. (262 aa)
modAMolybdate transporter; ABC superfamily (peri_perm); similar to E. coli molybdate-binding periplasmic protein; permease (AAC73850.1); Blastp hit to AAC73850.1 (257 aa), 86% identity in aa 1 - 257. (257 aa)
modBMolybdate transporter; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa)
modCMolybdate transporter; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
moaAMolybdopterin biosynthesis, protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
moaBMolybdopterin biosynthesis, protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
moaCMolybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa)
moaDSimilar to E. coli molybdopterin biosynthesis (AAC73871.1); Blastp hit to AAC73871.1 (81 aa), 86% identity in aa 1 - 81. (83 aa)
moaEMolybdopterin converting factor, subunit 2; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family. (150 aa)
ybhLPutative permease; Similar to E. coli orf, hypothetical protein (AAC73873.1); Blastp hit to AAC73873.1 (234 aa), 87% identity in aa 1 - 234; Belongs to the BI1 family. (234 aa)
ybhMPutative integral membrane protein; Similar to E. coli orf, hypothetical protein (AAC73874.1); Blastp hit to AAC73874.1 (237 aa), 31% identity in aa 24 - 228. (235 aa)
STM0809Putative inner membrane protein. (202 aa)
STM0810Putative inner membrane protein. (186 aa)
moeBMolybdopterin biosynthesis; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD. (249 aa)
moeAMolybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP; Belongs to the MoeA family. (413 aa)
hcrNADH oxidoreductase for hcp gene product; Similar to E. coli putative enzyme (AAC73959.1); Blastp hit to AAC73959.1 (322 aa), 90% identity in aa 1 - 322. (323 aa)
hcpHybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (550 aa)
dmsASimilar to E. coli anaerobic dimethyl sulfoxide reductase subunit A (AAC73980.1); Blastp hit to AAC73980.1 (785 aa), 93% identity in aa 1 - 784; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa)
dmsBSimilar to E. coli anaerobic dimethyl sulfoxide reductase subunit B (AAC73981.1); Blastp hit to AAC73981.1 (205 aa), 96% identity in aa 1 - 205. (205 aa)
dmsCSimilar to E. coli anaerobic dimethyl sulfoxide reductase subunit C (AAC73982.1); Blastp hit to AAC73982.1 (287 aa), 89% identity in aa 1 - 287. (287 aa)
scsASuppression of copper sensitivity: putative copper binding protein; Suppressor for copper-sensitivity A (gi|2327003). (120 aa)
scsBSuppression of copper sensitivity protein; Suppressor for copper-sensitivity B (gi|2327004). (628 aa)
scsCSuppression of copper sensitivity protein; Suppressor for copper-sensitivity C (gi|2327005). (207 aa)
scsDSuppression of copper sensitivity protein; Suppressor for copper-sensitivity D (gi|2327006). (168 aa)
yeaRPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 83% identity in aa 1 - 119. (120 aa)
yoaGPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74866.1); Blastp hit to AAC74866.1 (60 aa), 96% identity in aa 1 - 60. (60 aa)
yeaAHypothetical protein; Putative domain frequently associated with peptide methionine sulfoxide reductase; similar to E. coli orf, hypothetical protein (AAC74848.1); Blastp hit to AAC74848.1 (137 aa), 85% identity in aa 1 - 137. (147 aa)
selDSelenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (347 aa)
ynfIPutative component of anaerobic dehydrogenases; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein; Belongs to the TorD/DmsD family. DmsD subfamily. (204 aa)
STM1496Similar to E. coli putative DMSO reductase anchor subunit (AAC74662.1); Blastp hit to AAC74662.1 (284 aa), 76% identity in aa 1 - 284. (285 aa)
STM1497Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit B (AAC73981.1); Blastp hit to AAC73981.1 (205 aa), 96% identity in aa 1 - 205. (205 aa)
STM1498Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 91% identity in aa 2 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
STM1499Putative dimethyl sulphoxide reductase, chain A1; Similar to E. coli putative oxidoreductase, major subunit (AAC74659.1); Blastp hit to AAC74659.1 (808 aa), 86% identity in aa 1 - 808; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (813 aa)
hypA-2Putative hydrogenase; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
STM1532Putative dehydrogenase protein. (295 aa)
STM1533Putative hydrogenase; Similar to E. coli nickel incorporation into hydrogenase-1 proteins (AAC74062.1); Blastp hit to AAC74062.1 (285 aa), 32% identity in aa 7 - 281. (353 aa)
STM1534Putative hydrogenase; Similar to E. coli processing of HyaA and HyaB proteins (AAC74061.1); Blastp hit to AAC74061.1 (132 aa), 36% identity in aa 17 - 115. (136 aa)
STM1535Putative hydrogenase protein. (99 aa)
STM1536Putative hydrogenase maturation protease; Similar to E. coli processing of HyaA and HyaB proteins (AAC74060.1); Blastp hit to AAC74060.1 (195 aa), 53% identity in aa 6 - 183. (202 aa)
STM1537Similar to E. coli probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit (AAC74059.1); Blastp hit to AAC74059.1 (235 aa), 54% identity in aa 1 - 222. (247 aa)
STM1538Similar to E. coli hydrogenase-1 large subunit (AAC74058.1); Blastp hit to AAC74058.1 (597 aa), 66% identity in aa 1 - 597. (600 aa)
STM1539Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 72% identity in aa 1 - 371. (367 aa)
fdnINitrate-inducible; similar to E. coli formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit (AAD13440.1); Blastp hit to AAD13440.1 (217 aa), 98% identity in aa 1 - 217. (218 aa)
fdnHFormate dehydrogenase-N, Fe-S beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
fdnGPutative molybdopterin oxidoreductases; Similar to E. coli formate dehydrogenase-N, nitrate-inducible, alpha subunit (AAD13438.1); Blastp hit to AAD13438.1 (1015 aa), 93% identity in aa 1 - 1015; contains selenocysteine tRNA suppressible codon. (1015 aa)
narUMFS superfamily nitrate extrusion protein; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. (462 aa)
narZSimilar to E. coli cryptic nitrate reductase 2, alpha subunit (AAC74550.1); Blastp hit to AAC74550.1 (1246 aa), 90% identity in aa 1 - 1246; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1246 aa)
narYSimilar to E. coli cryptic nitrate reductase 2, beta subunit (AAC74549.1); Blastp hit to AAC74549.1 (514 aa), 94% identity in aa 1 - 514. (514 aa)
narWAssembly function; similar to E. coli cryptic nitrate reductase 2, delta subunit, assembly function (AAC74548.1); Blastp hit to AAC74548.1 (231 aa), 82% identity in aa 1 - 231. (231 aa)
narVSimilar to E. coli cryptic nitrate reductase 2, gamma subunit (AAC74547.1); Blastp hit to AAC74547.1 (226 aa), 96% identity in aa 1 - 226. (226 aa)
narISimilar to E. coli nitrate reductase 1, cytochrome b(NR), gamma subunit (AAC74311.1); Blastp hit to AAC74311.1 (225 aa), 92% identity in aa 1 - 225. (225 aa)
narJNitrate reductase 1, delta subunit; Chaperone required for molybdenum cofactor assembly in nitrate reductase 1; similar to E. coli nitrate reductase 1, delta subunit, assembly function (AAC74310.1); Blastp hit to AAC74310.1 (236 aa), 88% identity in aa 1 - 236. (236 aa)
narHSimilar to E. coli nitrate reductase 1, beta subunit (AAC74309.1); Blastp hit to AAC74309.1 (512 aa), 92% identity in aa 1 - 511. (511 aa)
narGSimilar to E. coli nitrate reductase 1, alpha subunit (AAC74308.1); Blastp hit to AAC74308.1 (1247 aa), 95% identity in aa 1 - 1247; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa)
narKSimilar to E. coli nitrite extrusion protein (AAC74307.1); Blastp hit to AAC74307.1 (463 aa), 94% identity in aa 1 - 462. (465 aa)
narXSensory histidine kinase in two component regulatory system with NarL; Senses nitrate/nitrite; regulates anaerobic respiration and fermentation; similar to E. coli nitrate/nitrate sensor, histidine protein kinase acts on NarL regulator (AAC74306.1); Blastp hit to AAC74306.1 (598 aa), 86% identity in aa 1 - 598. (598 aa)
narLResponse regulator in two-component regulatory system with NarX (or NarQ); Regulates anaerobic respiration and fermentation (LuxR/UhpA family); similar to E. coli pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes (AAC74305.1); Blastp hit to AAC74305.1 (216 aa), 96% identity in aa 1 - 216. (216 aa)
STM1786Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 92% identity in aa 1 - 372. (372 aa)
STM1787Similar to E. coli hydrogenase-1 large subunit (AAC74058.1); Blastp hit to AAC74058.1 (597 aa), 91% identity in aa 1 - 597. (597 aa)
STM1788Similar to E. coli probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit (AAC74059.1); Blastp hit to AAC74059.1 (235 aa), 83% identity in aa 6 - 235. (243 aa)
STM1789Putative hydrogenase maturation protease; Similar to E. coli processing of HyaA and HyaB proteins (AAC74060.1); Blastp hit to AAC74060.1 (195 aa), 88% identity in aa 1 - 192. (198 aa)
STM1790Putative thiol-disulfide isomerase and thioredoxin; Similar to E. coli processing of HyaA and HyaB proteins (AAC74061.1); Blastp hit to AAC74061.1 (132 aa), 72% identity in aa 1 - 125. (134 aa)
STM1791Putative hydrogenase-1 protein; Similar to E. coli nickel incorporation into hydrogenase-1 proteins (AAC74062.1); Blastp hit to AAC74062.1 (285 aa), 75% identity in aa 1 - 279. (282 aa)
dsbBPutative disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family. (176 aa)
STM1808Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113. (113 aa)
narPResponse regulator in two-component regulatory system with NarQ (or NarX); Similar to E. coli nitrate/nitrite response regulator (sensor NarQ) (AAC75253.1); Blastp hit to AAC75253.1 (215 aa), 88% identity in aa 1 - 215. (215 aa)
ccmHPutative heme lyase subunit; Possible subunit of a heme lyase. (347 aa)
ccmGHeme lyase/disulfide oxidoreductase; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. (185 aa)
ccmFSimilar to E. coli cytochrome c-type biogenesis protein (AAC75256.1); Blastp hit to AAC75256.1 (647 aa), 85% identity in aa 1 - 646. (643 aa)
ccmEPeriplasmic heme-dependent peroxidase; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
ccmDHeme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (70 aa)
ccmCHeme exporter protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa)
ccmBABC superfamily (membrane) heme exporter protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (219 aa)
ccmAABC superfamily (membrane) heme exporter protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (205 aa)
napCPeriplasmic nitrate reductase; Cytochrome c-type biogenesis protein; similar to E. coli cytochrome c-type protein (AAC75262.1); Blastp hit to AAC75262.1 (200 aa), 88% identity in aa 1 - 200. (200 aa)
napBPeriplasmic small subunit nitrate reductase of cytochrome C550; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (149 aa)
napHFerredoxin-type protein; Electron transfer; similar to E. coli ferredoxin-type protein: electron transfer (AAC75264.1); Blastp hit to AAC75264.1 (287 aa), 88% identity in aa 1 - 280. (289 aa)
napGFerredoxin-type protein; Electron transfer; similar to E. coli ferredoxin-type protein: electron transfer (AAC75265.1); Blastp hit to AAC75265.1 (231 aa), 94% identity in aa 1 - 231. (231 aa)
napAPeriplasmic large subunit nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
napDPeriplasmic nitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. (87 aa)
napFFerredoxin-type protein; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family. (163 aa)
narQSimilar to E. coli sensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL) (AAC75522.1); Blastp hit to AAC75522.1 (566 aa), 88% identity in aa 3 - 565. (566 aa)
STM2527Putative polyferredoxin; Similar to E. coli hydrogenase 4 Fe-S subunit (AAC75541.1); Blastp hit to AAC75541.1 (181 aa), 36% identity in aa 33 - 124, 40% identity in aa 42 - 90. (287 aa)
STM2528Putative dimethylsulfoxide reductase; Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit C (AAC73982.1); Blastp hit to AAC73982.1 (287 aa), 32% identity in aa 6 - 277. (269 aa)
STM2529Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit B (AAC73981.1); Blastp hit to AAC73981.1 (205 aa), 56% identity in aa 4 - 193. (209 aa)
STM2530Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 42% identity in aa 15 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (801 aa)
hmpADihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
yfhHPutative ABC superfamily transport protein; Membrane; similar to E. coli orf, hypothetical protein (AAC75614.1); Blastp hit to AAC75614.1 (306 aa), 83% identity in aa 25 - 306. (282 aa)
STM2574Similar to E. coli putative resistance protein (AAC76571.1); Blastp hit to AAC76571.1 (402 aa), 28% identity in aa 10 - 399. (398 aa)
ygaAPutative EBP family regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. (506 aa)
norVPutative flavoprotein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (479 aa)
ygbDPutative oxidoreductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (377 aa)
hypFHydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (746 aa)
hydNSimilar to E. coli involved in electron transport from formate to hydrogen, Fe-S centers (AAC75755.1); Blastp hit to AAC75755.1 (175 aa), 95% identity in aa 1 - 173. (181 aa)
STM2844Putative periplasmic or exported protein. (269 aa)
hycISimilar to E. coli protease involved in processing C-terminal end of the large subunit of hydrogenase 3 (AAC75759.1); Blastp hit to AAC75759.1 (156 aa), 91% identity in aa 1 - 155. (156 aa)
hycHProtein for processing of HycE; Part of the FHL complex; similar to E. coli processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex) (AAC75760.1); Blastp hit to AAC75760.1 (136 aa), 91% identity in aa 1 - 136. (136 aa)
hycGSimilar to E. coli hydrogenase activity (AAC75761.1); Blastp hit to AAC75761.1 (255 aa), 96% identity in aa 1 - 255. (255 aa)
hycFHydrogenase 3; Similar to E. coli probable iron-sulfur protein of hydrogenase 3 (part of FHL complex) (AAC75762.1); Blastp hit to AAC75762.1 (180 aa), 96% identity in aa 1 - 178; putative quinone oxidoreductase. (180 aa)
hycEPart of FHL complex; similar to E. coli large subunit of hydrogenase 3 (part of FHL complex) (AAC75763.1); Blastp hit to AAC75763.1 (569 aa), 97% identity in aa 1 - 569. (569 aa)
hycDHydrogenase 3, membrane subunit; Part of FHL complex; similar to E. coli membrane-spanning protein of hydrogenase 3 (part of FHL complex) (AAC75764.1); Blastp hit to AAC75764.1 (307 aa), 90% identity in aa 1 - 307. (307 aa)
hycCHydrogenase 3, membrane subunit; Part of FHL complex; similar to E. coli membrane-spanning protein of hydrogenase 3 (part of FHL complex) (AAC75765.1); Blastp hit to AAC75765.1 (608 aa), 88% identity in aa 1 - 608. (608 aa)
hycBHydrogenase-3, iron-sulfur subunit; Part of FHL complex; similar to E. coli probable small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) (AAC75766.1); Blastp hit to AAC75766.1 (203 aa), 95% identity in aa 1 - 202. (202 aa)
hycASimilar to E. coli transcriptional repression of hyc and hyp operons (AAC75767.1); Blastp hit to AAC75767.1 (153 aa), 88% identity in aa 1 - 152. (153 aa)
hypAGuanine-nucleotide binding protein in formate-hydrogenlyase system; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (118 aa)
hypBHydrogenase-3 accessory protein; Assembly of metallocenter; similar to E. coli guanine-nucleotide binding protein, functions as nickel donor for large subunit of hydrogenase 3 (AAC75769.1); Blastp hit to AAC75769.1 (290 aa), 94% identity in aa 1 - 290. (290 aa)
hypCPutative hydrogenase expression/formation protein; Similar to E. coli pleiotrophic effects on 3 hydrogenase isozymes (AAC75770.1); Blastp hit to AAC75770.1 (90 aa), 96% identity in aa 1 - 90. (90 aa)
hypDPutative hydrogenase expression/formation protein; Similar to E. coli pleiotrophic effects on 3 hydrogenase isozymes (AAC75771.1); Blastp hit to AAC75771.1 (373 aa), 94% identity in aa 1 - 372; Belongs to the HypD family. (373 aa)
hypEPutative hydrogenase expression/formation protein; Similar to E. coli plays structural role in maturation of all 3 hydrogenases (AAC75772.1); Blastp hit to AAC75772.1 (322 aa), 91% identity in aa 1 - 322. (322 aa)
ygbAPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75774.1); Blastp hit to AAC75774.1 (117 aa), 86% identity in aa 1 - 114. (114 aa)
dsbCProtein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase. (237 aa)
STM3141Molybdenum-binding periplasmic protein. (236 aa)
STM3142Putative ferrichrome-binding periplasmic protein. (350 aa)
hybGSimilar to E. coli hydrogenase-2 operon protein: may effect maturation of large subunit of hydrogenase-2 (AAC76026.1); Blastp hit to AAC76026.1 (82 aa), 93% identity in aa 1 - 82. (82 aa)
hybFPutative hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hybEPutative hydrogenase; Similar to E. coli member of hyb operon (AAC76028.1); Blastp hit to AAC76028.1 (162 aa), 80% identity in aa 1 - 162. (162 aa)
hybDSimilar to E. coli probable processing element for hydrogenase-2 (AAC76029.1); Blastp hit to AAC76029.1 (164 aa), 94% identity in aa 1 - 163. (164 aa)
hybCSimilar to E. coli probable large subunit, hydrogenase-2 (AAC76030.1); Blastp hit to AAC76030.1 (567 aa), 94% identity in aa 1 - 567. (567 aa)
hybBSimilar to E. coli probable cytochrome Ni/Fe component of hydrogenase-2 (AAC76031.1); Blastp hit to AAC76031.1 (392 aa), 96% identity in aa 1 - 392. (392 aa)
hybAUnknown; Intitally thought to be hydrogenase-2 small subunit which now identified as hybO; similar to E. coli hydrogenase-2 small subunit (AAC76032.1); Blastp hit to AAC76032.1 (328 aa), 95% identity in aa 1 - 328. (328 aa)
hypOPutative Ni/Fe hydrogenases, small subunit; Similar to E. coli putative hydrogenase subunit (AAC76033.1); Blastp hit to AAC76033.1 (372 aa), 96% identity in aa 1 - 372. (372 aa)
STM3191Putative arylsulfate sulfotransferase. (321 aa)
STM3192Putative arylsulfate sulfotransferase. (264 aa)
dsbLPutative thiol-disulfide isomerase and thioredoxin; Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT. (223 aa)
dsbIPutative disulfide isomerase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT. (225 aa)
yhbTPutative lipid carrier protein; Similar to E. coli orf, hypothetical protein (AAC76191.1); Blastp hit to AAC76191.1 (174 aa), 90% identity in aa 1 - 174. (174 aa)
yhbUSimilar to E. coli putative collagenase (AAC76192.1); Blastp hit to AAC76192.1 (331 aa), 96% identity in aa 1 - 331. (331 aa)
yhbVPutative protease; Similar to E. coli orf, hypothetical protein (AAC76193.1); Blastp hit to AAC76193.1 (298 aa), 91% identity in aa 1 - 298. (298 aa)
yhbWPutative alkanal monooxygenase; Similar to E. coli putative enzyme (AAC76194.1); Blastp hit to AAC76194.1 (335 aa), 95% identity in aa 1 - 335. (335 aa)
yhdHSimilar to E. coli putative dehydrogenase (AAC76285.1); Blastp hit to AAC76285.1 (324 aa), 88% identity in aa 1 - 323. (324 aa)
msrPPutative nitrate reductase; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The cata [...] (334 aa)
msrQPutative inner membrane protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. Msr [...] (199 aa)
nirBSimilar to E. coli nitrite reductase (NAD(P)H) subunit (AAC76390.1); Blastp hit to AAC76390.1 (847 aa), 95% identity in aa 1 - 847; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
nirDNitrite reductase small subunit; Required for activity of the reductase. (108 aa)
nirCFNT family nitrite transport protein; Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane; Belongs to the FNT transporter (TC 2.A.44) family. (269 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (457 aa)
bisCSimilar to E. coli biotin sulfoxide reductase (AAC76575.1); Blastp hit to AAC76575.1 (739 aa), 86% identity in aa 2 - 739; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (777 aa)
ysaAPutative oxidoreductase; Similar to E. coli orf, hypothetical protein (AAC76597.1); Blastp hit to AAC76597.1 (157 aa), 72% identity in aa 1 - 156. (157 aa)
selBSimilar to E. coli selenocysteinyl-tRNA-specific translation factor (AAC76614.1); Blastp hit to AAC76614.1 (614 aa), 85% identity in aa 1 - 614. (616 aa)
selASelenocysteine synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa)
yidRPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76712.1); Blastp hit to AAC76712.1 (416 aa), 79% identity in aa 13 - 416. (408 aa)
ccmH-2Putative heme lyase subunit; Possible subunit of a heme lyase. (347 aa)
ccmG-2Heme lyase disulfide oxidoreductase; Cytochrome c-type biogenesis; similar to E. coli disulfide oxidoreductase (in biogenesis of cytochrome c? (AAC75255.1); Blastp hit to AAC75255.1 (185 aa), 87% identity in aa 1 - 185. (185 aa)
ccmF-2Similar to E. coli cytochrome c-type biogenesis protein (AAC75256.1); Blastp hit to AAC75256.1 (647 aa), 85% identity in aa 1 - 646. (643 aa)
ccmE-2Periplasmic heme-dependent peroxidase; Cytochrome c-type biogenesis protein; similar to E. coli cytochrome c biogenesis, possible subunit of a heme lyase (AAC75257.1); Blastp hit to AAC75257.1 (159 aa), 82% identity in aa 1 - 159. (159 aa)
ccmD-2Cytochrome c-type biogenesis protein; similar to E. coli heme exporter protein C (AAC75258.1); Blastp hit to AAC75258.1 (69 aa), 77% identity in aa 1 - 69. (70 aa)
ccmC-2Cytochrome c-type biogenesis protein; similar to E. coli heme exporter protein C (AAC75259.1); Blastp hit to AAC75259.1 (245 aa), 86% identity in aa 1 - 245. (245 aa)
ccmB-2Heme exporter protein; ABC superfamily (membrane); cytochrome c-type biogenesis protein; similar to E. coli heme exporter protein B, cytochrome c-type biogenesis protein (AAC75260.1); Blastp hit to AAC75260.1 (220 aa), 84% identity in aa 2 - 220. (219 aa)
ccmA-2Heme exporter protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (205 aa)
STM3820Similar to E. coli putative cytochrome C peroxidase (AAC76543.1); Blastp hit to AAC76543.1 (465 aa), 82% identity in aa 2 - 463. (466 aa)
torDCytoplasmic chaperone which interacts with TorA; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (210 aa)
torATrimethylamine N-oxide reductase subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (850 aa)
torCTrimethylamine N-oxide reductase; Cytochrome c-type subunit; also has activity as negativer regulator of tor operon; similar to E. coli trimethylamine N-oxide reductase, cytochrome c-type subunit (AAC74081.1); Blastp hit to AAC74081.1 (390 aa), 90% identity in aa 1 - 388; Belongs to the TorC/TorY family. (394 aa)
torRTwo-component system, OmpR family, torCAD operon response regulator TorR; Regulates tor operon (TorR family); similar to E. coli response transcriptional regulator for torA (sensor TorS) (AAC74080.1); Blastp hit to AAC74080.1 (230 aa), 81% identity in aa 1 - 229. (230 aa)
torTTMAO reductase system periplasmic protein TorT; Regulates tor operon; similar to E. coli part of regulation of tor operon, periplasmic (AAC74079.1); Blastp hit to AAC74079.1 (342 aa), 65% identity in aa 1 - 342. (346 aa)
torSHistidine kinase; Regulates tor operon; similar to E. coli sensor protein torS (regulator TorR) (AAC74078.1); Blastp hit to AAC74078.1 (904 aa), 62% identity in aa 1 - 896. (911 aa)
STMD1.9Putative outer membrane protein. (237 aa)
STM3981Putative cytoplasmic protein. (352 aa)
mobBGTP-binding; similar to E. coli molybdopterin-guanine dinucleotide biosynthesis protein B (AAC76854.1); Blastp hit to AAC76854.1 (170 aa), 77% identity in aa 1 - 167. (171 aa)
mobAPutative molybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa)
dsbAPeriplasmic protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily. (207 aa)
fdhEPutative formate dehydrogenase formation protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (309 aa)
fdoISimilar to E. coli formate dehydrogenase, cytochrome B556 (FDO) subunit (AAD13454.1); Blastp hit to AAD13454.1 (211 aa), 96% identity in aa 1 - 211. (211 aa)
fdoHFormate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
fdoGSimilar to E. coli formate dehydrogenase-O, major subunit (AAD13456.1); Blastp hit to AAD13456.1 (1016 aa), 93% identity in aa 1 - 1016. (1016 aa)
fdhDPutative formate dehydrogenase formation protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (278 aa)
STM4098Putative arylsulfate sulfotransferase. (596 aa)
STM4276Putative cytoplasmic protein. (48 aa)
nrfANitrite reductase periplasmic cytochrome c(552); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
nrfBFormate-dependent nitrite reductase; A penta-haeme cytochrome c; similar to E. coli formate-dependent nitrite reductase; a penta-haeme cytochrome c (AAC77041.1); Blastp hit to AAC77041.1 (190 aa), 88% identity in aa 1 - 190. (217 aa)
nrfCFe-S centers; similar to E. coli formate-dependent nitrite reductase; Fe-S centers (AAC77042.1); Blastp hit to AAC77042.1 (223 aa), 91% identity in aa 1 - 223. (223 aa)
nrfDSimilar to E. coli formate-dependent nitrate reductase complex; transmembrane protein (AAC77043.1); Blastp hit to AAC77043.1 (318 aa), 85% identity in aa 1 - 318. (318 aa)
nrfEFormate-dependent nitrite reductase; Possible subunit of a heme lyase. (740 aa)
nrfGInvolved in attachment of haem c to cytochrome c552; similar to E. coli part of formate-dependent nitrite reductase complex (AAD13459.1); Blastp hit to AAD13459.1 (198 aa), 71% identity in aa 6 - 196. (206 aa)
fdhFFormate dehydrogenase; Similar to E. coli selenopolypeptide subunit of formate dehydrogenase H (AAD13462.1); Blastp hit to AAD13462.1 (715 aa), 97% identity in aa 1 - 714; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)
STM4305Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit A (AAC73980.1); Blastp hit to AAC73980.1 (785 aa), 51% identity in aa 3 - 784; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (783 aa)
STM4306Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit B (AAC73981.1); Blastp hit to AAC73981.1 (205 aa), 60% identity in aa 4 - 205. (208 aa)
STM4307Putative anaerobic dimethyl sulfoxide reductase, subunit C; Similar to E. coli putative DMSO reductase anchor subunit (AAC74662.1); Blastp hit to AAC74662.1 (284 aa), 34% identity in aa 6 - 274. (257 aa)
STM4308Putative component of anaerobic dehydrogenases; Similar to E. coli putative oxidoreductase component (AAC74663.1); Blastp hit to AAC74663.1 (207 aa), 33% identity in aa 14 - 206. (217 aa)
dsbDThiol:disulfide interchange protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (567 aa)
yjeBPutative negative regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide. (141 aa)
ytfEPutative cell morphogenesis; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. (220 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (212 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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