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hypA-2 hypA-2 STM1533 STM1533 STM1534 STM1534 STM1535 STM1535 STM1536 STM1536 STM1537 STM1537 STM1538 STM1538 STM1539 STM1539 STM1786 STM1786 STM1787 STM1787 STM1788 STM1788 STM1789 STM1789 STM1790 STM1790 STM1791 STM1791 STM3141 STM3141 STM3142 STM3142 hybG hybG hybF hybF hybE hybE hybD hybD hybC hybC hybB hybB hybA hybA hypO hypO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hypA-2Putative hydrogenase; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
STM1533Putative hydrogenase; Similar to E. coli nickel incorporation into hydrogenase-1 proteins (AAC74062.1); Blastp hit to AAC74062.1 (285 aa), 32% identity in aa 7 - 281. (353 aa)
STM1534Putative hydrogenase; Similar to E. coli processing of HyaA and HyaB proteins (AAC74061.1); Blastp hit to AAC74061.1 (132 aa), 36% identity in aa 17 - 115. (136 aa)
STM1535Putative hydrogenase protein. (99 aa)
STM1536Putative hydrogenase maturation protease; Similar to E. coli processing of HyaA and HyaB proteins (AAC74060.1); Blastp hit to AAC74060.1 (195 aa), 53% identity in aa 6 - 183. (202 aa)
STM1537Similar to E. coli probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit (AAC74059.1); Blastp hit to AAC74059.1 (235 aa), 54% identity in aa 1 - 222. (247 aa)
STM1538Similar to E. coli hydrogenase-1 large subunit (AAC74058.1); Blastp hit to AAC74058.1 (597 aa), 66% identity in aa 1 - 597. (600 aa)
STM1539Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 72% identity in aa 1 - 371. (367 aa)
STM1786Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 92% identity in aa 1 - 372. (372 aa)
STM1787Similar to E. coli hydrogenase-1 large subunit (AAC74058.1); Blastp hit to AAC74058.1 (597 aa), 91% identity in aa 1 - 597. (597 aa)
STM1788Similar to E. coli probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit (AAC74059.1); Blastp hit to AAC74059.1 (235 aa), 83% identity in aa 6 - 235. (243 aa)
STM1789Putative hydrogenase maturation protease; Similar to E. coli processing of HyaA and HyaB proteins (AAC74060.1); Blastp hit to AAC74060.1 (195 aa), 88% identity in aa 1 - 192. (198 aa)
STM1790Putative thiol-disulfide isomerase and thioredoxin; Similar to E. coli processing of HyaA and HyaB proteins (AAC74061.1); Blastp hit to AAC74061.1 (132 aa), 72% identity in aa 1 - 125. (134 aa)
STM1791Putative hydrogenase-1 protein; Similar to E. coli nickel incorporation into hydrogenase-1 proteins (AAC74062.1); Blastp hit to AAC74062.1 (285 aa), 75% identity in aa 1 - 279. (282 aa)
STM3141Molybdenum-binding periplasmic protein. (236 aa)
STM3142Putative ferrichrome-binding periplasmic protein. (350 aa)
hybGSimilar to E. coli hydrogenase-2 operon protein: may effect maturation of large subunit of hydrogenase-2 (AAC76026.1); Blastp hit to AAC76026.1 (82 aa), 93% identity in aa 1 - 82. (82 aa)
hybFPutative hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hybEPutative hydrogenase; Similar to E. coli member of hyb operon (AAC76028.1); Blastp hit to AAC76028.1 (162 aa), 80% identity in aa 1 - 162. (162 aa)
hybDSimilar to E. coli probable processing element for hydrogenase-2 (AAC76029.1); Blastp hit to AAC76029.1 (164 aa), 94% identity in aa 1 - 163. (164 aa)
hybCSimilar to E. coli probable large subunit, hydrogenase-2 (AAC76030.1); Blastp hit to AAC76030.1 (567 aa), 94% identity in aa 1 - 567. (567 aa)
hybBSimilar to E. coli probable cytochrome Ni/Fe component of hydrogenase-2 (AAC76031.1); Blastp hit to AAC76031.1 (392 aa), 96% identity in aa 1 - 392. (392 aa)
hybAUnknown; Intitally thought to be hydrogenase-2 small subunit which now identified as hybO; similar to E. coli hydrogenase-2 small subunit (AAC76032.1); Blastp hit to AAC76032.1 (328 aa), 95% identity in aa 1 - 328. (328 aa)
hypOPutative Ni/Fe hydrogenases, small subunit; Similar to E. coli putative hydrogenase subunit (AAC76033.1); Blastp hit to AAC76033.1 (372 aa), 96% identity in aa 1 - 372. (372 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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