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yaeC yaeC yaeE yaeE abc abc STM0458 STM0458 sfbA sfbA sfbB sfbB sfbC sfbC ybdH ybdH ybdL ybdL STM1127 STM1127 orf48 orf48 orf32 orf32 orf245 orf245 orf408 orf408 ttrA ttrA ttrC ttrC ttrB ttrB ttrS ttrS ttrR ttrR STM1557 STM1557 ydcZ ydcZ yedO yedO phsC phsC phsB phsB phsA phsA yfeC yfeC cysK cysK cysM cysM cysA cysA cysW cysW cysU cysU cysP cysP sseA-2 sseA-2 asrA asrA asrB asrB asrC asrC cysC cysC cysN cysN cysD cysD cysH cysH cysI cysI cysJ cysJ metK metK metC metC glpR glpR glpG glpG glpE glpE STM3548 STM3548 STM3549 STM3549 STM3550 STM3550 STM3624A STM3624A cysE cysE metR metR metE metE sbp sbp metJ metJ metB metB metF metF metA metA metH metH cysQ cysQ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
yaeCPutative outer membrane lipoprotein; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. (271 aa)
yaeEPutative ABC superfamily (membrane) transport protein; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity). (217 aa)
abcPutative ABC superfamily (atp_bind) transport system; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
STM0458Putative cysteine synthase/cystathionine beta-synthase; Similar to E. coli cysteine synthase B, O-acetylserine sulfhydrolase B (AAC75474.1); Blastp hit to AAC75474.1 (303 aa), 26% identity in aa 6 - 207, 35% identity in aa 198 - 289. (351 aa)
sfbAPutative ABC-type transport system ATPase component/cell division protein; Similar to E. coli putative lipoprotein (AAC73308.1); Blastp hit to AAC73308.1 (271 aa), 37% identity in aa 14 - 258. (276 aa)
sfbBPutative ABC-type transport system ATPase component/cell division protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (338 aa)
sfbCPutative binding-protein-dependent transport systems inner membrane component; Similar to E. coli putative transport system permease protein (AAC73309.1); Blastp hit to AAC73309.1 (217 aa), 44% identity in aa 15 - 217. (219 aa)
ybdHPutative glycerol dehydrogenase; Similar to E. coli putative oxidoreductase (AAC73700.1); Blastp hit to AAC73700.1 (362 aa), 81% identity in aa 1 - 361. (362 aa)
ybdLSimilar to E. coli putative aminotransferase (AAC73701.1); Blastp hit to AAC73701.1 (386 aa), 85% identity in aa 1 - 386. (386 aa)
STM1127Putative transcriptional regulator; Similar to E. coli orf, hypothetical protein (AAC75480.1); Blastp hit to AAC75480.1 (285 aa), 29% identity in aa 15 - 264. (293 aa)
orf48Amino acid permease YeeF like protein (gi|1526981). (447 aa)
orf32Putative hydrolase or acyltransferase; Proline iminopeptidase like protein (gi|1526980). (297 aa)
orf245Putative cytoplasmic protein; ORF 245 (gi|4456875). (245 aa)
orf408Putative regulatory protein, deoR family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (408 aa)
ttrATetrathionate reductase complex, subunit A; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrA is the catalytic subunit. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1020 aa)
ttrCTetrathionate reductase complex, subunit C; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrC probably anchors TtrA and TtrB to the periplasmic face of the cytoplasmic membrane. May transfer electrons from membrane quinol to TtrB. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. Belongs to the NrfD family. (340 aa)
ttrBTetrathionate reductase complex, subunit B; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrB is probably involved in transfer of electrons from TtrC to TtrA. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (250 aa)
ttrSTetrathionate reductase complex: sensory transduction histidine kinase; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to tetrathionate, and transfers its phosphate group to TtrR. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (592 aa)
ttrRTetrathionate reductase complex: response regulator; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Positively regulates transcription of the ttrBCA operon. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (206 aa)
STM1557Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. (400 aa)
ydcZPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74529.1); Blastp hit to AAC74529.1 (149 aa), 86% identity in aa 1 - 149. (149 aa)
yedOPutative 1-cyclopropane-carboxylate deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa)
phsCHydrogen sulfide production membrane anchoring protein; Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsC subunit anchors the complex to the membrane and contains the site for menaquinol oxidation. (254 aa)
phsBHydrogen sulfide production iron-sulfur subunit; Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsB subunit transfers electrons between PhsC and PhsA. (192 aa)
phsAHydrogen sulfide production membrane anchoring protein; Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsA subunit contains the active site molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor. (758 aa)
yfeCPutative negative regulator; Similar to E. coli orf, hypothetical protein (AAC75455.1); Blastp hit to AAC75455.1 (119 aa), 79% identity in aa 1 - 119. (120 aa)
cysKSubunit of cysteine synthase A and O-acetylserine sulfhydrolase A; Two cysteine synthase enzymes are found, this enzyme and CysM; both catalyze the same reaction. Cysteine synthase B (CysM) can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. (323 aa)
cysMCysteine synthase B; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. (303 aa)
cysASulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
cysWThiosulfate permease W protein; ABC superfamily (membrane); similar to E. coli sulfate transport system permease W protein (AAC75476.1); Blastp hit to AAC75476.1 (149 aa), 99% identity in aa 1 - 149. (291 aa)
cysUThiosulfate transport protein; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane (By similarity). (277 aa)
cysPThiosulfate transport protein; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport (By similarity). (338 aa)
sseA-2Similar to E. coli putative thiosulfate sulfurtransferase (AAC75574.1); Blastp hit to AAC75574.1 (334 aa), 80% identity in aa 54 - 332. (280 aa)
asrAAnaerobic sulfide reductase; Electron transfer protein for anaerobic sulfite reductase subunit A. (347 aa)
asrBAnaerobic sulfide reductase; This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine. (272 aa)
asrCAnaerobic sulfide reductase; This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (337 aa)
cysCAdenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
cysNATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
cysDATP-sulfurylase, subunit 1; Similar to E. coli ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2 (AAC75794.1); Blastp hit to AAC75794.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
cysH3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite; Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
cysINADPH dependent sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
cysJSulfite reductase, beta (flavoprotein) subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa)
metKMethionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
metCCystathionine beta-lyase; Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. (395 aa)
glpRDeoR family; similar to E. coli repressor of the glp operon (AAC76448.1); Blastp hit to AAC76448.1 (252 aa), 93% identity in aa 1 - 252. (252 aa)
glpGProtein of glp regulon; Rhomboid-type serine protease that catalyzes intramembrane proteolysis. (276 aa)
glpEThiosulfate/cyanide sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (108 aa)
STM3548Putative cytoplasmic protein; ORF 245 (gi|4456875). (253 aa)
STM3549Putative inner membrane protein. (323 aa)
STM3550Similar to E. coli putative hydrolase (AAC76404.1); Blastp hit to AAC76404.1 (292 aa), 28% identity in aa 24 - 289, 71% identity in aa 7 - 20. (344 aa)
STM3624ACystathionine gamma-synthase. (46 aa)
cysESerine acetyltransferase. (SW:CYSE_SALTY); Belongs to the transferase hexapeptide repeat family. (273 aa)
metRRegulator for metE and metH; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression; Belongs to the LysR transcriptional regulatory family. (317 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
sbpSulfate transport protein; This protein specifically binds sulfate and is involved in its transmembrane transport; Belongs to the prokaryotic sulfate-binding protein family. (329 aa)
metJTranscriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family. (105 aa)
metBSimilar to E. coli cystathionine gamma-synthase (AAC76921.1); Blastp hit to AAC76921.1 (386 aa), 96% identity in aa 1 - 386. (386 aa)
metF5,10-methylenetetrahydrofolate reductase. (SW:METF_SALTY); Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
metAHomoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa)
metHB12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1256 aa)
cysQCysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. (246 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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