node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STM1557 | metB | STM1557 | STM4100 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | Similar to E. coli cystathionine gamma-synthase (AAC76921.1); Blastp hit to AAC76921.1 (386 aa), 96% identity in aa 1 - 386. | 0.949 |
STM1557 | metC | STM1557 | STM3161 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | Cystathionine beta-lyase; Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. | 0.931 |
STM1557 | metE | STM1557 | STM3965 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.903 |
STM1557 | metH | STM1557 | STM4188 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.928 |
STM1557 | sseA-2 | STM1557 | STM2533 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | Similar to E. coli putative thiosulfate sulfurtransferase (AAC75574.1); Blastp hit to AAC75574.1 (334 aa), 80% identity in aa 54 - 332. | 0.901 |
STM1557 | yedO | STM1557 | STM1953 | Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. | Putative 1-cyclopropane-carboxylate deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. | 0.907 |
STM3624A | metA | STM3624A | STM4182 | Cystathionine gamma-synthase. | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.930 |
STM3624A | metC | STM3624A | STM3161 | Cystathionine gamma-synthase. | Cystathionine beta-lyase; Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. | 0.960 |
STM3624A | metE | STM3624A | STM3965 | Cystathionine gamma-synthase. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.709 |
STM3624A | metF | STM3624A | STM4105 | Cystathionine gamma-synthase. | 5,10-methylenetetrahydrofolate reductase. (SW:METF_SALTY); Belongs to the methylenetetrahydrofolate reductase family. | 0.798 |
STM3624A | metH | STM3624A | STM4188 | Cystathionine gamma-synthase. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.854 |
STM3624A | metJ | STM3624A | STM4099 | Cystathionine gamma-synthase. | Transcriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family. | 0.752 |
STM3624A | metK | STM3624A | STM3090 | Cystathionine gamma-synthase. | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.430 |
metA | STM3624A | STM4182 | STM3624A | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | Cystathionine gamma-synthase. | 0.930 |
metA | metB | STM4182 | STM4100 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | Similar to E. coli cystathionine gamma-synthase (AAC76921.1); Blastp hit to AAC76921.1 (386 aa), 96% identity in aa 1 - 386. | 0.997 |
metA | metC | STM4182 | STM3161 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | Cystathionine beta-lyase; Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. | 0.869 |
metA | metE | STM4182 | STM3965 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.911 |
metA | metF | STM4182 | STM4105 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 5,10-methylenetetrahydrofolate reductase. (SW:METF_SALTY); Belongs to the methylenetetrahydrofolate reductase family. | 0.979 |
metA | metH | STM4182 | STM4188 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.829 |
metA | metJ | STM4182 | STM4099 | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | Transcriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family. | 0.754 |