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yaeD yaeD ghmA ghmA rfaE rfaE rfaD rfaD rfaF rfaF rfaC rfaC rfaL rfaL rfaK rfaK rfaZ rfaZ rfaY rfaY rfaJ rfaJ rfaI rfaI rfaB rfaB yibR yibR rfaP rfaP rfaG rfaG rfaQ rfaQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yaeDPutative dehydratase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. (188 aa)
ghmAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (192 aa)
rfaEPutative sugar nucleotide transferase domain of ADP-L-glycero-D-manno-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
rfaDADP-L-glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (310 aa)
rfaFADP-heptose; AFP-heptose--lps heptosyltransferase II. (SW:RFAF_SALTY). (348 aa)
rfaCHeptosyl transferase I; Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA; Belongs to the glycosyltransferase 9 family. (317 aa)
rfaLO-antigen ligase; Adds the O-antigen on the glucose(II) group of LPS. (404 aa)
rfaKPutative hexose transferase; Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (381 aa)
rfaZLipopolysaccharide core biosynthesis protein RFAZ. (SW:RFAZ_SALTY). (269 aa)
rfaYLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. RfaY/WaaY family. (232 aa)
rfaJUDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS. (336 aa)
rfaIUDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase; Adds the galactose(I) group on the glucose(I) group of LPS. (337 aa)
rfaBUDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Adds a galactose goup to a glucose group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (359 aa)
yibRPutative inner membrane protein; Hypothetical 9.0 Kda protein in rfaB-rfaP intergenic region. (SW:YIBR_SALTY). (77 aa)
rfaPLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. (265 aa)
rfaGSimilar to E. coli glucosyltransferase I; lipopolysaccharide core biosynthesis (AAC76655.1); Blastp hit to AAC76655.1 (374 aa), 86% identity in aa 1 - 374. (374 aa)
rfaQModification of heptose region of core; similar to E. coli lipopolysaccharide core biosynthesis (AAC76656.1); Blastp hit to AAC76656.1 (344 aa), 78% identity in aa 1 - 344. (344 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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