(13 nodes) Mixed, incl. ABC-2 transporter, and Nitroreductase family network (Salmonella enterica Typhimurium)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	nfnB	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). (217 aa)
	ybhR	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73879.1); Blastp hit to AAC73879.1 (368 aa), 95% identity in aa 1 - 368. (368 aa)
	ybhS	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73880.1); Blastp hit to AAC73880.1 (377 aa), 94% identity in aa 6 - 377. (376 aa)
	ybhF	Putative ABC-type multidrug transport system, ATPase component; Similar to E. coli putative ATP-binding component of a transport system (AAC73881.1); Blastp hit to AAC73881.1 (583 aa), 91% identity in aa 6 - 583. (578 aa)
	ybhG	Membrane permease predicted cation efflux pump; Similar to E. coli putative membrane protein (AAC73882.1); Blastp hit to AAC73882.1 (332 aa), 87% identity in aa 2 - 332. (331 aa)
	ybiH	Putative transcriptional repressor (TetR/AcrR family); Similar to E. coli putative transcriptional regulator (AAC73883.1); Blastp hit to AAC73883.1 (227 aa), 85% identity in aa 5 - 227. (224 aa)
	mdaA	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. (240 aa)
	ycaO	Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589. (586 aa)
	nemA	Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. (365 aa)
	STM2377	Putative inner membrane protein. (218 aa)
	yhhJ	Putative ABC superfamily transport protein; Atp_bind/membrane; similar to E. coli putative transporter (AAC76510.1); Blastp hit to AAC76510.1 (375 aa), 92% identity in aa 2 - 375. (374 aa)
	yhiH	Putative ABC-type multidrug transport system; ATPase component; Permease component of an ABC-transporter; similar to E. coli putative ATP-binding component of a transport system, fragment 1 (AAC76511.1); Blastp hit to AAC76511.1 (894 aa), 89% identity in aa 1 - 894. (896 aa)
	yhiI	Similar to E. coli putative membrane protein (AAC76512.1); Blastp hit to AAC76512.1 (355 aa), 87% identity in aa 1 - 355. (355 aa)

Your Current Organism:

Salmonella enterica Typhimurium

NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
STM2377	mdaA	STM2377	STM0874	Putative inner membrane protein.	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	0.442
STM2377	nfnB	STM2377	STM0578	Putative inner membrane protein.	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	0.442
STM2377	ybhR	STM2377	STM0815	Putative inner membrane protein.	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73879.1); Blastp hit to AAC73879.1 (368 aa), 95% identity in aa 1 - 368.	0.425
STM2377	ybhS	STM2377	STM0816	Putative inner membrane protein.	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73880.1); Blastp hit to AAC73880.1 (377 aa), 94% identity in aa 6 - 377.	0.425
STM2377	ycaO	STM2377	STM0975	Putative inner membrane protein.	Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589.	0.794
STM2377	yhhJ	STM2377	STM3585	Putative inner membrane protein.	Putative ABC superfamily transport protein; Atp_bind/membrane; similar to E. coli putative transporter (AAC76510.1); Blastp hit to AAC76510.1 (375 aa), 92% identity in aa 2 - 375.	0.425
STM2377	yhiH	STM2377	STM3586	Putative inner membrane protein.	Putative ABC-type multidrug transport system; ATPase component; Permease component of an ABC-transporter; similar to E. coli putative ATP-binding component of a transport system, fragment 1 (AAC76511.1); Blastp hit to AAC76511.1 (894 aa), 89% identity in aa 1 - 894.	0.682
mdaA	STM2377	STM0874	STM2377	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative inner membrane protein.	0.442
mdaA	nemA	STM0874	STM1436	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365.	0.906
mdaA	nfnB	STM0874	STM0578	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	0.995
mdaA	ybhR	STM0874	STM0815	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73879.1); Blastp hit to AAC73879.1 (368 aa), 95% identity in aa 1 - 368.	0.425
mdaA	ybhS	STM0874	STM0816	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative ABC superfamily (membrane) transport protein; Similar to E. coli orf, hypothetical protein (AAC73880.1); Blastp hit to AAC73880.1 (377 aa), 94% identity in aa 6 - 377.	0.430
mdaA	ycaO	STM0874	STM0975	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589.	0.624
mdaA	yhhJ	STM0874	STM3585	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative ABC superfamily transport protein; Atp_bind/membrane; similar to E. coli putative transporter (AAC76510.1); Blastp hit to AAC76510.1 (375 aa), 92% identity in aa 2 - 375.	0.424
mdaA	yhiH	STM0874	STM3586	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	Putative ABC-type multidrug transport system; ATPase component; Permease component of an ABC-transporter; similar to E. coli putative ATP-binding component of a transport system, fragment 1 (AAC76511.1); Blastp hit to AAC76511.1 (894 aa), 89% identity in aa 1 - 894.	0.625
nemA	mdaA	STM1436	STM0874	Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365.	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	0.906
nemA	nfnB	STM1436	STM0578	Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365.	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	0.920
nfnB	STM2377	STM0578	STM2377	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	Putative inner membrane protein.	0.442
nfnB	mdaA	STM0578	STM0874	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.	0.995
nfnB	nemA	STM0578	STM1436	Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).	Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365.	0.920

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