STRINGSTRING
yceB yceB STM4417 STM4417 STM4418 STM4418 STM4419 STM4419 STM4420 STM4420 STM4421 STM4421 STM4422 STM4422 STM4423 STM4423 iolE iolE iolG iolG srfJ srfJ STM4427 STM4427 STM4428 STM4428 STM4429 STM4429 STM4430 STM4430 STM4431 STM4431 STM4432 STM4432 STM4433 STM4433 STM4434 STM4434 STM4435 STM4435 STM4436 STM4436 STM4488 STM4488 STM4489 STM4489 STM4490 STM4490 STM4491 STM4491 STM4492 STM4492 STM4493 STM4493 STM4494 STM4494 STM4495 STM4495 STM4496 STM4496 STM4497 STM4497 STM4498 STM4498 hsdS hsdS hsdM hsdM hsdR hsdR mrr mrr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yceBPutative outer membrane lipoprotein; Hypothetical protein in pyrC 3'region. (SW:YCEB_SALTY). (186 aa)
STM4417Putative transcriptional regulator; Similar to E. coli orf, hypothetical protein (AAC75614.1); Blastp hit to AAC75614.1 (306 aa), 25% identity in aa 31 - 278. (277 aa)
STM4418Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 41% identity in aa 58 - 487, 47% identity in aa 5 - 103; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
STM4419Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 33% identity in aa 58 - 486, 39% identity in aa 3 - 106; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
STM4420Putative inner membrane protein. (269 aa)
STM4421Similar to E. coli phenylacetaldehyde dehydrogenase (AAC74467.1); Blastp hit to AAC74467.1 (500 aa), 34% identity in aa 22 - 500. (501 aa)
STM4422Putative cytoplasmic protein. (100 aa)
STM4423Similar to E. coli putative ARAC-type regulatory protein (AAC74766.1); Blastp hit to AAC74766.1 (303 aa), 27% identity in aa 38 - 283. (274 aa)
iolEPutative endonuclease; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family. (306 aa)
iolGPutative dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (336 aa)
srfJActivated by transcription factor SsrB; Similar to Homo sapiens lysosomal glucosyl ceramidase; SrfJ (gi|8347262); Belongs to the glycosyl hydrolase 30 family. (447 aa)
STM4427Putative endonuclease. (277 aa)
STM4428Similar to E. coli putative transport protein (AAC75382.1); Blastp hit to AAC75382.1 (392 aa), 48% identity in aa 9 - 391. (388 aa)
STM4429Putative cytoplasmic protein. (266 aa)
STM4430Putative sugar kinase; Ribokinase family. (645 aa)
STM4431Putative thiamine pyrophosphate-requiring enzyme; Similar to E. coli acetolactate synthase I, valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 27% identity in aa 26 - 326, 34% identity in aa 12 - 126; Belongs to the TPP enzyme family. (646 aa)
STM4432Putative thiamine pyrophosphate-requiring enzyme; Similar to E. coli glyoxylate carboligase (AAC73609.1); Blastp hit to AAC73609.1 (593 aa), 33% identity in aa 421 - 539. (269 aa)
STM4433Putative thiamine pyrophosphate-requiring enzyme; Oxidoreductase family; similar to E. coli putative virulence factor (AAC74152.1); Blastp hit to AAC74152.1 (307 aa), 29% identity in aa 1 - 188, 52% identity in aa 272 - 296. (340 aa)
STM4434Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 22% identity in aa 167 - 417, 21% identity in aa 40 - 145. (408 aa)
STM4435Putative cytoplasmic protein. (271 aa)
STM4436Putative endonuclease. (294 aa)
STM4488Similar to E. coli putative prophage integrase (AAC75495.1); Blastp hit to AAC75495.1 (431 aa), 39% identity in aa 35 - 123. (95 aa)
STM4489Putative superfamily I DNA helicases; Similar to E. coli putative frameshift suppressor (AAC77264.1); Blastp hit to AAC77264.1 (338 aa), 68% identity in aa 1 - 338. (1171 aa)
STM4490Putative Mrr restriction endonuclease. (329 aa)
STM4491Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363. (694 aa)
STM4492Putative cytoplasmic protein. (865 aa)
STM4493Putative cytoplasmic protein. (273 aa)
STM4494Putative ABC-type sugar/spermidine/putrescine transport systems, ATPase component. (363 aa)
STM4495Putative type II restriction enzyme, methylase subunit. (1225 aa)
STM4496Putative ATPase involved in DNA repair. (1213 aa)
STM4497Putative cytoplasmic protein. (200 aa)
STM4498Putative inner membrane protein. (200 aa)
hsdSSpecificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] (469 aa)
hsdMDNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. (529 aa)
hsdRHost restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. (1169 aa)
mrrSimilar to E. coli restriction of methylated adenine (AAC77307.1); Blastp hit to AAC77307.1 (304 aa), 77% identity in aa 1 - 304. (304 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.