STRINGSTRING
STM0159 STM0159 yacL yacL kdgT kdgT dtnK dtnK pdxA2 pdxA2 STM0164 STM0164 allA allA allR allR gcl gcl gip gip glxR glxR STM0520 STM0520 allP allP allB allB ybbY ybbY glxK glxK ylbA ylbA allC allC allD allD fdrA fdrA ylbE ylbE ylbF ylbF STM0649 STM0649 STM0650 STM0650 kdgT2 kdgT2 STM0652 STM0652 ybeL ybeL ycdW ycdW ydiH ydiH rspA rspA rspB rspB ydfI ydfI STM2913 STM2913 STM2914 STM2914 ygbM ygbM ygbL ygbL ygbK ygbK ygbJ ygbJ ygbI ygbI STM2959 STM2959 gudD gudD ygcY ygcY gudT gudT kduD kduD kduI kduI STM3079 STM3079 STM3080 STM3080 STM3081 STM3081 STM3082 STM3082 STM3083 STM3083 STM3134 STM3134 uxuA uxuA STM3136 STM3136 uxaC uxaC STM3169 STM3169 STM3170 STM3170 ygiK ygiK garK garK garR garR garL garL garD garD kdgK kdgK STM3631 STM3631 yiaE yiaE dgoT dgoT dgoA dgoA dgoK dgoK dgoR dgoR STM3832 STM3832 STM3833 STM3833 STM4052 STM4052 STM4053 STM4053 yiiZ yiiZ yiiM yiiM STM4057 STM4057
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STM0159Putative restriction endonuclease. (280 aa)
yacLPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family. (120 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
dtnKPutative inner membrane protein; Catalyzes the ATP-dependent phosphorylation of D-threonate to D-threonate 4-phosphate. Can also phosphorylate 4- hydroxy-L-threonine, with lower efficiency. This side reaction may serve to deal with the toxicity of 4-hydroxy-L-threonine by converting it into 4-hydroxy-L-threonine 4-phosphate, a useful product that can be used by PdxA2. Belongs to the four-carbon acid sugar kinase family. (423 aa)
pdxA2Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use 4-hydroxy-L-threonine 4-phosphate as substrate. Belongs to the PdxA family. PdxA2 subfamily. (327 aa)
STM0164Similar to E. coli putative DEOR-type transcriptional regulator (AAC75777.1); Blastp hit to AAC75777.1 (265 aa), 34% identity in aa 16 - 265. (255 aa)
allAUreidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source. (160 aa)
allRPutative regulatory protein; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region (By similarity). (272 aa)
gclSimilar to E. coli glyoxylate carboligase (AAC73609.1); Blastp hit to AAC73609.1 (593 aa), 96% identity in aa 1 - 593; Belongs to the TPP enzyme family. (593 aa)
gipSimilar to E. coli glyoxylate-induced protein (AAC73610.1); Blastp hit to AAC73610.1 (258 aa), 84% identity in aa 1 - 258; Belongs to the hyi family. (258 aa)
glxRTartronic semialdehyde reductase; Similar to E. coli putative oxidoreductase (AAC73611.1); Blastp hit to AAC73611.1 (292 aa), 91% identity in aa 1 - 292. (292 aa)
STM0520Similar to E. coli putative transport protein, cryptic, orf, joins former yjiZ and yjjL (AAC77312.1); Blastp hit to AAC77312.1 (453 aa), 24% identity in aa 40 - 439. (415 aa)
allPSimilar to E. coli putative transport protein (AAC73613.1); Blastp hit to AAC73613.1 (437 aa), 92% identity in aa 1 - 437. (437 aa)
allBAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa)
ybbYSimilar to E. coli putative transport (AAC73615.1); Blastp hit to AAC73615.1 (435 aa), 79% identity in aa 8 - 435. (432 aa)
glxKGlycerate kinase II; Similar to E. coli orf, hypothetical protein (AAC73616.1); Blastp hit to AAC73616.1 (381 aa), 80% identity in aa 1 - 379; Belongs to the glycerate kinase type-1 family. (382 aa)
ylbAPutative glyoxylate utilization; Similar to E. coli orf, hypothetical protein (AAC73617.1); Blastp hit to AAC73617.1 (261 aa), 92% identity in aa 1 - 261. (261 aa)
allCAllantoate amidohydrolase; Similar to E. coli putative hydantoin utilization protein (AAC73618.1); Blastp hit to AAC73618.1 (411 aa), 88% identity in aa 1 - 411. (411 aa)
allDSimilar to E. coli putative malate dehydrogenase (AAC73619.1); Blastp hit to AAC73619.1 (349 aa), 86% identity in aa 1 - 349; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa)
fdrASimilar to E. coli involved in protein transport; multicopy suppressor of dominant negative ftsH mutants (AAC73620.1); Blastp hit to AAC73620.1 (555 aa), 82% identity in aa 1 - 555. (554 aa)
ylbEPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73621.1); Blastp hit to AAC73621.1 (333 aa), 94% identity in aa 1 - 332. (419 aa)
ylbFPutative cytoplasmic protein; Similar to E. coli putative carboxylase (AAC73622.1); Blastp hit to AAC73622.1 (271 aa), 65% identity in aa 1 - 269. (269 aa)
STM0649Putative hydrolase N-terminus; Similar to E. coli altronate hydrolase (AAC76126.1); Blastp hit to AAC76126.1 (495 aa), 38% identity in aa 4 - 82. (113 aa)
STM0650Similar to E. coli putative hydrolase (AAC76162.1); Blastp hit to AAC76162.1 (523 aa), 35% identity in aa 167 - 521, 32% identity in aa 119 - 223. (390 aa)
kdgT2Putative permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
STM0652Putative sigma-54 dependent transcriptional regulator; Similar to E. coli response regulator of ato, ornithine decarboxylase antizyme (sensor ATOS) (AAC75280.1); Blastp hit to AAC75280.1 (461 aa), 37% identity in aa 67 - 453. (642 aa)
ybeLSimilar to E. coli putative alpha helical protein (AAC73744.1); Blastp hit to AAC73744.1 (160 aa), 91% identity in aa 1 - 160. (157 aa)
ycdWPutative oxidoreductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
ydiHPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74755.1); Blastp hit to AAC74755.1 (89 aa), 89% identity in aa 24 - 89. (75 aa)
rspAPutative dehydratase; Similar to E. coli starvation sensing protein (AAC74653.1); Blastp hit to AAC74653.1 (404 aa), 94% identity in aa 1 - 404. (404 aa)
rspBPutative dehydrogenase; Similar to E. coli starvation sensing protein (AAC74652.1); Blastp hit to AAC74652.1 (339 aa), 75% identity in aa 1 - 339. (339 aa)
ydfIPutative mannitol dehydrogenase; Similar to E. coli putative oxidoreductase (AAC74615.1); Blastp hit to AAC74615.1 (486 aa), 81% identity in aa 1 - 484; Belongs to the mannitol dehydrogenase family. (488 aa)
STM2913Similar to E. coli putative transport protein (AAC75782.1); Blastp hit to AAC75782.1 (454 aa), 33% identity in aa 11 - 446. (498 aa)
STM2914Putative nucleoside-diphosphate-sugar epimerase; Similar to E. coli UDP-galactose-4-epimerase (AAC73846.1); Blastp hit to AAC73846.1 (338 aa), 25% identity in aa 1 - 162. (316 aa)
ygbMPutative endonuclease; Similar to E. coli orf, hypothetical protein (AAC75781.1); Blastp hit to AAC75781.1 (258 aa), 79% identity in aa 1 - 258; Belongs to the hyi family. (258 aa)
ygbLSimilar to E. coli putative epimerase/aldolase (AAC75780.1); Blastp hit to AAC75780.1 (212 aa), 85% identity in aa 1 - 211. (212 aa)
ygbKPutative tRNA synthase; Catalyzes the ATP-dependent phosphorylation of 3-oxo- tetronate to 3-oxo-tetronate 4-phosphate. Belongs to the four-carbon acid sugar kinase family. (420 aa)
ygbJSimilar to E. coli putative dehydrogenase (AAC75778.1); Blastp hit to AAC75778.1 (302 aa), 82% identity in aa 1 - 299. (307 aa)
ygbIPutative regulatory protein, deoR family; Similar to E. coli putative DEOR-type transcriptional regulator (AAC75777.1); Blastp hit to AAC75777.1 (265 aa), 86% identity in aa 11 - 263. (254 aa)
STM2959Putative glycerate kinase 2; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 68% identity in aa 28 - 405; Belongs to the glycerate kinase type-1 family. (380 aa)
gudDD-glucarate dehydratase; Similar to E. coli putative glucarate dehydratase (AAC75829.1); Blastp hit to AAC75829.1 (446 aa), 97% identity in aa 1 - 446. (446 aa)
ygcYSimilar to E. coli putative glucarate dehydratase (AAC75830.1); Blastp hit to AAC75830.1 (446 aa), 95% identity in aa 1 - 446. (446 aa)
gudTPutative MFS superfamily D-glucarate permease; Similar to E. coli putative transport protein (AAC75831.1); Blastp hit to AAC75831.1 (450 aa), 96% identity in aa 1 - 450. (452 aa)
kduDSimilar to E. coli 2-deoxy-D-gluconate 3-dehydrogenase (AAC75881.1); Blastp hit to AAC75881.1 (253 aa), 93% identity in aa 1 - 253; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
kduIPutative pectin degrading enzyme; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family. (278 aa)
STM3079Putative hydrolase or acyltransferase; Similar to E. coli orf, hypothetical protein (AAC73780.1); Blastp hit to AAC73780.1 (254 aa), 22% identity in aa 18 - 234. (318 aa)
STM3080Putative mannitol dehydrogenase; Similar to E. coli orf, hypothetical protein (AAC77209.1); Blastp hit to AAC77209.1 (153 aa), 38% identity in aa 4 - 150. (157 aa)
STM3081Similar to E. coli putative malate dehydrogenase (AAC73619.1); Blastp hit to AAC73619.1 (349 aa), 40% identity in aa 3 - 332; L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (335 aa)
STM3082Putative zinc-binding dehydrogenase; Similar to E. coli putative oxidoreductase (AAC77314.1); Blastp hit to AAC77314.1 (345 aa), 54% identity in aa 9 - 345. (338 aa)
STM3083Putative mannitol dehydrogenase; Similar to E. coli putative oxidoreductase (AAC75233.1); Blastp hit to AAC75233.1 (488 aa), 49% identity in aa 1 - 477; Belongs to the mannitol dehydrogenase family. (490 aa)
STM3134Putative permease; Similar to E. coli transport of hexuronates (AAC76128.1); Blastp hit to AAC76128.1 (472 aa), 47% identity in aa 43 - 454. (434 aa)
uxuAPutative mannonate hydrolase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (394 aa)
STM3136Similar to E. coli D-mannonate oxidoreductase (AAC77279.1); Blastp hit to AAC77279.1 (486 aa), 79% identity in aa 4 - 486; Belongs to the mannitol dehydrogenase family. (490 aa)
uxaCSimilar to E. coli uronate isomerase (AAC76127.1); Blastp hit to AAC76127.1 (470 aa), 67% identity in aa 1 - 468. (470 aa)
STM3169Similar to E. coli putative solute-binding transport protein (AAC76603.1); Blastp hit to AAC76603.1 (328 aa), 28% identity in aa 7 - 320. (327 aa)
STM3170Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76601.1); Blastp hit to AAC76601.1 (157 aa), 26% identity in aa 1 - 135. (160 aa)
ygiKPutative integral membrane protein; Possible transporter; hypothetical 46.1 Kda protein in plsC 3'region. (SW:YGIK_SALTY). (435 aa)
garKGlycerate kinase; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 86% identity in aa 28 - 408; Belongs to the glycerate kinase type-1 family. (381 aa)
garRTartronate semialdehyde reductase (TSAR); Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (296 aa)
garL2-dehydro-3-deoxy-galactarate Aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. (256 aa)
garDGalactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. (523 aa)
kdgKSimilar to E. coli ketodeoxygluconokinase (AAC76551.1); Blastp hit to AAC76551.1 (382 aa), 92% identity in aa 74 - 381. (309 aa)
STM3631Similar to E. coli putative permease (AAC75926.1); Blastp hit to AAC75926.1 (505 aa), 27% identity in aa 54 - 466. (441 aa)
yiaE2-keto-D-gluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
dgoTMFS family D-galactonate transport protein; Similar to E. coli D-galactonate transport (AAC76714.1); Blastp hit to AAC76714.1 (445 aa), 90% identity in aa 1 - 445. (445 aa)
dgoAGalactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa)
dgoKSimilar to E. coli 2-oxo-3-deoxygalactonate kinase (AAC76716.1); Blastp hit to AAC76716.1 (292 aa), 81% identity in aa 1 - 292. (292 aa)
dgoRGalactonate operon transcriptional repressor; GntR family; similar to E. coli regulator protein for dgo operon (AAC76718.1); Blastp hit to AAC76718.1 (128 aa), 94% identity in aa 1 - 112. (229 aa)
STM3832Similar to E. coli putative transport protein (AAC75831.1); Blastp hit to AAC75831.1 (450 aa), 27% identity in aa 15 - 435. (420 aa)
STM3833Putative mandelate racemase; Muconate lactonizing enzyme family; similar to E. coli starvation sensing protein (AAC74653.1); Blastp hit to AAC74653.1 (404 aa), 28% identity in aa 18 - 385; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (397 aa)
STM4052Putative C4-dicarboxylate transport system; Similar to E. coli putative membrane protein (AAC76602.1); Blastp hit to AAC76602.1 (424 aa), 33% identity in aa 5 - 412. (435 aa)
STM4053Putative C4-dicarboxylate transport system; Similar to E. coli orf, hypothetical protein (AAC76601.1); Blastp hit to AAC76601.1 (157 aa), 25% identity in aa 4 - 151. (171 aa)
yiiZPutative dicarboxylate-binding periplasmic protein; Hypothetical protein in sodA 5'region. (SW:YIIZ_SALTY). (327 aa)
yiiMPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76892.1); Blastp hit to AAC76892.1 (234 aa), 76% identity in aa 4 - 233. (250 aa)
STM4057Putative inner membrane protein. (131 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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